708-DS Dissolution Tester –

Installation Checklist

Thank you for purchasing an Agilent instrument solution. This checklist is used by the installing
engineer to ensure that the instrument and associated systems are correctly installed, upgraded and
functioning as designed in your facility. This checklist will be completed at the end of the service and
provided to you as a record of the installation.

Customer Information
 Customers should provide all necessary operating supplies upon request of the engineer.

Service Engineer’s Responsibilities

 Only complete/printout pages that relate to the system being installed.
 Complete empty fields with the relevant information
 Complete the relevant checkboxes in the checklist using a “X” or tick mark “” in the checkbox.
 Complete Not Applicable check boxes to indicate services not delivered, as needed
 Complete the Service Review section together with the customer

Additional Instruction Notes

 Contact the customer to insure they supply the appropriate algaecide or water treatment for filling
the water bath. Ensure that the algaecide or treatment is compatible with PETG and vinyl plastics.

Issued: 9-Feb-2012, Revision: 2.0 Copyright1 2011 Agilent Technologies

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Installation Checklist

System Information
Guidance
 Check this box if an instrument configuration report is attached instead of completing the table.

Instrument system name and ID

Instrument system site and location

List system component product numbers List the serial numbers of each component
1. 1.

2. 2.

3. 3.

4. 4.

5. 5.

6. 6.

7. 7.

8. 8.

9. 9.

10. 10.

Issued: 9-Feb-2012, Revision: 2.0 Copyright2 2011 Agilent Technologies

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Installation Checklist

General Preparation
 Unpack/verify the condition and completeness of shipment. For discrepancies, use the table below.
Product or part description Observation Action

 Discuss any specific questions or issues with the customer prior to starting.
 Discuss any configuration options with the customer prior to starting
 Check for required service note applicability and firmware updates if connecting to instruments.
 Upgrades only – Ensure with customer that instrument control settings, data, methods etc have been
properly saved or archived prior to starting any installation procedures.
 Verify line voltage, voltage settings, and power cord.

Place the tester on the workbench

 Place the tester on the workbench.

Setup Heater-Circulator
 Ensure the heater-circulator has been installed beneath the back of the vessel plate with the power
outlet facing the right and the legs inserted into the holes in the base plate.
 Ensure the isolators on the legs of the heater-circulator are properly positioned to eliminate
vibration from the heater-circulator.
 Ensure the two stainless steel clamps have been installed to properly secure the tubing to the heater-
circulator.
 Check the remaining connections of the heater-circulator tubing on each side of the water bath.
 Connect the six-pin cable to the rear of the heater-circulator and the other end into the position
marked BATH HEATER on the rear panel of the dissolution apparatus.

Install Temperature Probe

 Insert the water bath temperature probe into the BATH TEMP jack on the rear of the drive unit on
the dissolution apparatus.
 Place the other end of the temperature probe through the hole in the center of the vessel plate in the
water bath.
 If applicable, insert the External Vessel Temperature Probe cable into the VESSEL TEMP jack on the
rear of the dissolution apparatus drive unit.
 Place the External Vessel Temperature Probe in the hole in the vessel plate, at the left-side rear of the
apparatus.

Issued: 9-Feb-2012, Revision: 2.0 Copyright3 2011 Agilent Technologies

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Installation Checklist

Connect Power Cords and Power On

 Connect or verify connections of power cords to all components.
 Plug the cords into electrical outlets of the appropriate voltage.
 Turn on the power of the dissolution apparatus using the switch located on the left side of the drive
unit.
 Ensure the serial number displayed matches the serial number label on the front of the instrument.
 Ensure the self test conducted upon initialization passes, which is indicated by a green check mark.
 If applicable, verify communication with other components in the system.

Level the Tester

 Remove the black caps from the five (5) screws located on the front, side, and rear of the base plate
of the dissolution apparatus.
 Raise the side stability feet located toward the back on either side of the base plate so they are not
touching the laboratory bench.
 Using the 90 Allen key in the top of the front level-adjustment screws, adjust the screws to achieve
left-to-right level within tolerance. It may be necessary to loosen the nut(s) beneath the base plate to
allow for adjustment.
 Using the 90 Allen key in the top of the rear level-adjustment screw, adjust the screw to achieve
front-to-back level within tolerance. It may be necessary to lift the heater-circulator to gain access to
this screw.
 Verify the level of the dissolution apparatus.
 Once the unit is leveled, use the open-end wrench to tighten the nut(s) below the base plate.
 Lower the side stability feet located toward the back on either side of the base plate until they touch
the laboratory bench. Do not over-tighten to ensure level is maintained.
 Re-install the black caps on all of the screws.

Fill the Water Bath

 If necessary, raise the drive unit to allow for access to the water bath.
 Fill the water bath to an appropriate level with purified water and additives specified by the
customer, using the label affixed to the bath as a guide. Be sure to allow for displacement of the
water once the dissolution vessels are installed.
 With the water bath filled, re-verify the instrument level front to back and right to left.

Issued: 9-Feb-2012, Revision: 2.0 Copyright4 2011 Agilent Technologies

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Power on Heater-Circulator
 Turn on the power to the heater-circulator using the switch located on the unit.
 Ensure the water flow through the heater-circulator begins. To release air trapped in the pump or
heater cartridge, refer to the "PRIMING THE PUMP" sticker on the left side of the heater-circulator.
 Ensure no leaks are present at any of the tubing connections.

Install Vessels
 If necessary, raise the drive unit to the fully raised position.
 Carefully install the dissolution vessels in the vessel plate.
 For the standard vessel, rotate the two clips for each position over the rim of the vessel to secure it
in place.
 If necessary, place the TruAlign blank vessel position covers on the vessel plate openings at Position
7 and Position 8. Rotate the two clips for each position over the cover to secure it in place.

Install Sample Manifold

 Section NOT applicable.
 From the Main screen, press Menu, then Diagnostics.
 Position the sample manifold so the center screw is aligned with the center receptor beneath the
drive unit. Ensure the left and right alignment cylinders are also positioned correctly.
 Push the manifold up into the drive unit until resistance is met.
 While gently lifting upward, press Load from within the Manifold Control box. The internal drive
should slowly lift the manifold to its fully raised position.
 If the unit is equipped with AutoTemp, attach the RS232 cable from the left side of the manifold to
the left connector on the underside of the drive unit. Attached the RS232 cable from the right side of
the manifold to the right connector on the underside of the drive unit.
 If the unit is equipped with autosampling, locate the black sample tubing fasteners and attach the
fastener to the sample tubing wrap.
 If applicable, affix the fasteners to the underside of the drive unit. A fastener is affixed to the left and
to the right of the center drive unit lift.
 Connect the tubing to the system. Ensure each line is attached to its identical color.

Issued: 9-Feb-2012, Revision: 2.0 Copyright5 2011 Agilent Technologies

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Installation Checklist

Install Accessory
 Section NOT applicable.
 Locate the appropriate accessories from the following list to be configured with the Agilent 708-DS
being qualified: evaporation covers, Dosage Delivery Modules (DDMs) or Cover Aligners, receptor
shafts, paddle shafts, basket shafts, shaft locking collars.
 Raise the drive unit to its fully raised position.
 If applicable, insert a receptor shaft (spin on / off shafts only) into each spindle location.
 Slide an evaporation cover over the shafts to be installed and insert the shaft into each spindle
location.
 Place a shaft locking collar on the top of each shaft and slide it down until it rests on top of the drive
unit.
 For all applicable positions, insert a DDM or Cover Aligner into the DDM Alignment Shaft hanging
from the underside of the drive unit.
 For all applicable positions, attach the DDM or Cover Aligner to the evaporation cover by aligning the
notch with the locking pin on the cover and pushing until fully seated.
 Ensure that the sampling port of the evaporation cover is aligned properly with the sample manifold
probes, if applicable.

Issued: 9-Feb-2012, Revision: 2.0 Copyright6 2011 Agilent Technologies

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Installation Checklist

Set Date / Time

 From the Menu screen, press Instrument, then Date / Time.
 Press MM/DD/YY to toggle between alternate date formats. Select the format that is most
appropriate.
 Touch the Date box and enter the current date in the proper format.
 Press Ok. The Date and Time window displays.
 Touch the Time box and enter the current time in HH:MM.
 Press Ok. The Date and Time window displays.
 Record the input time and the initial time displayed on the calibrated timer in the following table:
Input Time
Actual time input by user (HH:MM:SS)
Initial time displayed on calibrated timer (HH:MM:SS)
After at least one hour
Time displayed on Agilent 708-DS (HH:MM:SS)
Time displayed on calibrated timer
Tolerance: Time displayed on the Agilent 708-DS equals the time Pass Fail
displayed on the calibrated timer ± 5 seconds

 While pressing Ok to clear the Date and Time window, begin the calibrated timer.
 Verify the clock setting relative to the calibrated timer after a minimum of one hour and record the
data in the table beneath above.
 Press Finish, then Main to return to the Main screen.

Serial Number / Firmware Verification

 From the Main screen, press Menu, then Instrument.
 Ensure the serial number shown on the screen matches the serial number printed on the tag on the
rear of the apparatus.
 Enter the serial number and firmware version shown on this screen into the table below.
Model Firmware Version Serial number
708-DS

 Place a check mark beneath any the options installed on the 708-DS in the table below.
AutoDrive AutoSampling AutoTemp DDM EVT Probe Printer

Issued: 9-Feb-2012, Revision: 2.0 Copyright7 2011 Agilent Technologies

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Installation Checklist

Vessel Temperature Probe Verification

 Section Not Applicable
 Fill each dissolution vessel with approximately 900 mL of purified water, and lower the drive unit to
its operating position.
 From the Main screen, press Run, then Manual.
 Enter the following parameters from the Manual Operation screen by pressing the appropriate box:
 Bath Temp: 37.2 °C
 Spindle Speed: 50 RPM
 Media Volume: 900 mL
 Duration: 000:45:00 (HHH:MM:SS)
 Profile Print Interval: 000:00:00 (HHH:MM:SS)
 DDM Increment (if applicable): 000:00:00 (HHH:MM:SS)
 Apparatus type: Apparatus being qualified (1 or 2)
 Press Run.
 Allow the vessels to equilibrate for approximately 30 minutes.
 From the Main screen press the down arrow icon located within the Manifold box, to lower the
sample manifold.
 Ensure the individual thermistor probes of the Agilent 708-DS are sufficiently immersed in the water
of each vessel.
 Place a calibrated thermometer (e.g. 280-DS temperature probe) into Vessel 1.
 Once the temperature of the calibrated thermometer is equilibrated, record the value in the table
beneath
 Record the temperature displayed on the Main screen of the 708-DS that corresponds to Vessel 1 in
the following table.
 Repeat the last 3 steps for each remaining vessel position.
Position Calibrated Agilent 708-DS Probe (⁰C) Pass Fail N/A
Thermometer (°C)
1
2
3
4
5
6
7
8
EVT
Tolerance: Agilent 708-DS thermistor probe(s) = calibrated thermometer ± 0.2 °C

Issued: 9-Feb-2012, Revision: 2.0 Copyright8 2011 Agilent Technologies

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Installation Checklist

 If applicable, place the external vessel temp (EVT) probe and a calibrated thermometer in the vessel
at Position 1.
 Once the temperatures have equilibrated, record the values in the table above for the EVT Probe and
calibrated thermometer.
 If this system is not equipped with an EVT probe, check the box for N/A for the EVT probe.

Shaft Grip Test

 Pull up on the shaft locking ring located on the top of each shaft. Ensure the shaft remains in the up
position.
 Push each locking ring down, one at a time. Verify the shafts move down.

DDM Control Verification

 Section Not Applicable
 From the Main screen, press Menu, then Diagnostics.
 Within the DDM Control box, press the box that corresponds to Position 1.
 Ensure the DDM opens and closes properly.
 Repeat the last three steps for all remaining positions.
 Within the DDM Control box, press All.
 Ensure all DDMs open simultaneously and close properly.
 Press Finish, then Main to return to the main screen.

Raising / Lowering the Drive Unit - Manual

 Section Not Applicable
 Loosen the knob on the right side of the Agilent 708-DS and lift the drive unit to a fully raised
position.
 Tighten the knob and ensure the drive unit remains raised.
 Loosen the knob and lower the Agilent 708-DS / 709-DS drive unit to its operating position.
 Tighten the knob and ensure the drive unit remains lowered.

Raising / Lowering the Drive Unit - Automated

 Section Not Applicable
 From the Main screen, press Menu, then Diagnostics.
 Press and hold the up arrow icon, located in the Drive box, to move the drive unit to a fully raised
position.

Issued: 9-Feb-2012, Revision: 2.0 Copyright9 2011 Agilent Technologies

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 Ensure the motor shuts off when the drive has reached its maximum height.
 Press and hold the down arrow icon, located in the Drive box, to move the drive unit to a fully
lowered position.
 Ensure the motor shuts off when the drive has reached its operating position.
 Double-tap the up arrow icon, located in the Drive box, to move the drive unit to a fully raised
position automatically.

Raising / Lowering the Sample Manifold

 Section Not Applicable
 From the Main screen, press Menu then Diagnostics.
 Press the down arrow icon, located in the Manifold box, to lower the sample manifold. The manifold
lowers.
 Press the up arrow icon, located in the Manifold box, to raise the sample manifold. The manifold
rises to its home position (fully raised).

Lock Instrument Test

 From the Main screen, press the lock instrument icon.
 Touch anywhere inside the Enter Access Code rectangle. Enter 123456 and press Ok.
 Touch anywhere inside the Re-enter Access Code rectangle. Enter 123456 and press Ok.
 Press Ok to lock the instrument.
 Ensure the instrument is locked by attempting to press any button on the Main screen.
 Press the lock instrument icon and touch anywhere inside the Access Code rectangle.
 Enter 123456 to unlock the instrument. Press Ok, then Ok.
 Verify that the lock instrument icon displays as an open lock on the Main screen.

Timer Alarm Test

 From the Main screen, press Menu, then Alarms.
 Touch anywhere inside the Timer Alarm rectangle. Enter 01:00 (MM:SS) and press Ok. The Alarms
screen displays.
 While pressing Ok to exit the Alarms screen, start a calibrated timer.
 After one minute, the Alarm window displays indicating the alarm time has expired. Press Ok to
clear this window.
 Verify that the timer alarm sounds at 01:00 ± 2 seconds.

Issued: 9-Feb-2012, Revision: 2.0 Copyright10 2011 Agilent Technologies

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Standard Program Test

 From the Main screen, press Menu, then Method Editor.
 Touch anywhere inside the number box of the first available method. The Method Properties screen
displays.
 Touch anywhere inside the Name rectangle. Enter PM TEST using the keypad and press Ok.
 Select the appropriate Apparatus (1 or 2) based on the accessory installed.
 Touch anywhere inside the Duration rectangle. Enter 000:20:00 (HHH:MM:SS) and press Ok.
 If AutoTemp is installed, touch anywhere inside the Vessel Temp rectangle. Enter 37.0 and press Ok.
 Touch anywhere inside the Bath Temp rectangle. Enter 37.2 and press Ok.
 Touch anywhere inside the Spindle Speed rectangle. Enter 75 and press Ok.
 Touch anywhere inside the Media Volume rectangle. Enter 900 and press Ok.
 If paddles and DDMs are installed, touch anywhere inside the Rotation Start Delay rectangle. Enter 3
and press Ok.
 Ensure the Full Media Change box is unchecked and press Next to advance to the next Method
Properties screen.
 Place a check in the Enable Final Spin box.
 Touch anywhere inside the Final Spin RPM rectangle. Enter 250 and press Ok.
 Touch anywhere inside the Final Spin Duration rectangle. Enter 000:02:00 (HHH:MM:SS) and press
Ok.
 If DDMs are installed, touch anywhere inside the DDM Increment rectangle. Enter 000:00:00
(HHH:MM:SS) and press Ok.
 If a Report Center Printer is installed, touch anywhere inside the Profile Print Interval rectangle.
Enter 000:01:00 (HHH:MM:SS) and press Ok.
 Press Next to advance to the next Method Properties screen.
 If applicable (AutoSampling installed), place a check in the Enable Manifold box.
 If applicable (AutoTemp installed), place a check in the Initial and Final Temp boxes, respectively.
 If applicable, touch anywhere inside the Manifold Down Lead Time rectangle. Enter 000:00:30
(HHH:MM:SS) and press Ok.
 If applicable, touch anywhere inside the Manifold Down Duration rectangle. Enter 000:00:30
(HHH:MM:SS) and press Ok.
 Place a check in the Enable Sample Point Alarm box.
 Touch anywhere inside the Alarm Lead Time rectangle. Enter 000:01:00 (HHH:MM:SS) and press Ok.
 Press Next to advance to the next Method Properties screen.
 Press the oval marked number 1 to enter information for the first sample time point. The Timepoint
Properties window displays.
 Touch anywhere inside the first Timepoint rectangle. Enter 000:05:00 (HHH:MM:SS), and press Ok.
 Touch anywhere inside the Spindle RPM rectangle. Enter 75 and press Ok.
 Touch anywhere inside the Media Volume rectangle. Enter 900 and press Ok, then Ok.
 Repeat the last three steps to set up subsequent time points at 10:00 and 15:00 minutes.

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 Press Save to save the method.

 Press Return to return to the Menu screen.
 If a Report Center Printer is installed, press Reports, then Print Method, then number that
corresponds to "PM TEST."
 If applicable, attach a copy of the Method Summary printout to this Installation Check sheet.
 Press Ok, then Main to return to the Main screen.
 From the Main screen, press the Run icon and then the Method icon.
 From the Select Method screen, press the number that corresponds to "PM TEST."
 Touch anywhere inside the Lot rectangle. Enter ABC and press Ok.
 Touch anywhere inside the Batch rectangle. Enter 123 and press Ok.
 Touch anywhere inside the Note rectangle. Enter PM TEST and press Ok.
 Select Instant as the Start Option and press Ok.
 Use the table below to verify proper operation throughout the sample program:

Action Pass Fail N/A

Sample manifold lowers to measure initial vessel temperatures.

All DDMs open simultaneously.

Spindles rotate at 75 RPM.

Apparatus status - elapsed time, RPM, and bath temperature (if

applicable) - is printed every minute.
Sample point alarm sounds 60 seconds before each time point.

Manifold lowers 30 seconds before each time point.

Sample manifold rises 30 seconds after each time point.

Vessel temperatures are printed after each time point.

Final Spin at 250 RPM begins after the third time point and
continues for 2 minutes.
Sample manifold lowers to measure final vessel temperatures.

Method Complete window displays indicating successful completion

of the dissolution method.

 Press Ok to clear the Method Complete window.

 If applicable, attach a copy of the Run Report printout to this checklist.

Issued: 9-Feb-2012, Revision: 2.0 Copyright12 2011 Agilent Technologies

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Delayed Start Test

 From the Main screen, press the Run icon and then the Method icon.
 From the Select Method screen, press the number that corresponds to "PM TEST."
 Touch anywhere inside the Lot rectangle. Enter ABC and press Ok.
 Touch anywhere inside the Batch rectangle. Enter 123 and press Ok.
 Touch anywhere inside the Note rectangle. Enter DELAYED and press Ok.
 Select Bath Temperature as the Start Option.
 Place a check in the Time Delayed box.
 Touch anywhere inside the Time Delayed rectangle to bring up the date and time entry window.
 Touch anywhere inside the Date rectangle. Enter the current date in the appropriate format and
press Ok.
 Touch anywhere inside the Time rectangle. Enter a time 5 minutes or more from the current time
and press Ok.
 Press Ok twice to return to the Main screen.
 Ensure the Delayed Start window displays indicating the correct method start date and time.
 Ensure the method operations (e.g. bath or vessel preheating) start at the appropriate time.
 Once the method has begun successfully, press the Stop icon and then the Stop Method icon.

Service Review
 Attach available reports/printouts to this documentation.
 Record the time/date of installation or upgrade completion in the customer’s records/logbook.
 Complete the Service Review Comments section below if there are additional comments.
 Review the installation/upgrade with the customer.
 Explain Agilent warranty for instruments.
 Explain how to use manuals, guides, online help.
 Explain how to get self-help, FAQs from the web.
 Explain how to log an instrument service call, support services available.
 Advise customer of additional instrument training options.
 If the Instrument firmware was updated, record the details of the change in the Service Engineer’s
Comments box below or if necessary, in the customer’s IQ records.

Issued: 9-Feb-2012, Revision: 2.0 Copyright13 2011 Agilent Technologies

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Service Engineer Comments (optional)

If there are any specific points you wish to note as part of performing the installation or other items of
interest for the customer, please write in this box.

Issued: 9-Feb-2012, Revision: 2.0 Copyright14 2011 Agilent Technologies

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Other Important Customer Web Links

 How to get information on your product: Literature Library - http://www.agilent.com/chem/library
 Need to know more? - www.agilent.com/chem/education
 Need technical support, FAQs? - www.agilent.com/chem/techsupp
 Need supplies? - www.agilent.com/chem/supplies

Service Completion

Service request number __________________ Date service completed ________________________

Agilent signature __________________ Customer signature ________________________

Issued: 9-Feb-2012, Revision: 2.0 Copyright15 2011 Agilent Technologies

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