Scribd
Upload
8 views1 page

Respiratory Drug Chart

The document provides a comprehensive overview of various drugs affecting airway structure and function, categorized by their class, indications, mechanisms, and adverse reactions. It includes short-acting and long-acting beta-2 adrenoceptor agonists, muscarinic antagonists, inhaled and systemic glucocorticoids, PDE inhibitors, leukotriene receptor antagonists, and monoclonal antibodies. Additionally, it mentions selective toxicity drugs used for conditions like HIV and leukemia, highlighting their mechanisms and potential adverse effects.

Uploaded by

David Friedman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
8 views1 page

Respiratory Drug Chart

The document provides a comprehensive overview of various drugs affecting airway structure and function, categorized by their class, indications, mechanisms, and adverse reactions. It includes short-acting and long-acting beta-2 adrenoceptor agonists, muscarinic antagonists, inhaled and systemic glucocorticoids, PDE inhibitors, leukotriene receptor antagonists, and monoclonal antibodies. Additionally, it mentions selective toxicity drugs used for conditions like HIV and leukemia, highlighting their mechanisms and potential adverse effects.

Uploaded by

David Friedman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 1

Drugs Affecting Airway Structure and Function

Class Drug name Indications Mechanism Adverse reactions/Contraindications


Short - acting β 2 – - Salbutamol - Reliever: use as required - Tachycardia

adrenoceptor agonist
- Terbutaline for asthma - Tremor

(SABA)
- Hypokalemia

Long - acting β 2 – - Salmeterol (slow, 12 hr) - Preventer: combined with

adrenoceptor agonists
- Formoterol (fast, 12 hr) corticosteroids (GCS) for

(LABA)
- Indacaterol (fast, 24 hr) asthma

Non-selective muscarinic - Ipratropium bromide - COPD


receptor antagonist - Less effective in asthma
M3 - selective antagonist - Tiotropium bromide - COPD
(12hr) - Less effective in Asthma
- Glycopyrronium bromide
(24hr)
Inhaled glucocorticoid (ICS) - Beclomethasone - Asthma of all severity - Binds to GC receptor in cytoplasm - Dysphonia
- Budesonide - Triggers dissociation of hsp90 proteins from GC, - Oral candidiasis (mouth fungal
- Fluticasone propionate unmasking NLS for translocation to nucleus infection)
- Mometasone - Binds to GRE and activates transcription of GILZ, MKP-1,
- Ciclosenide and Iϰ Ba (anti-inflamm.)
- Also inhibits pro-inflamm. genes such as IL-8, COX-2,
ICAM8, and NOS2
Systemic (oral) glucocorticoid - Prednisolone - Acute exacerbations of - Osteoporosis
asthma - Diabetes
- Severe asthma - Muscle wasting
- COPD - Hypertension
- Growth suppression
PDE inhibitor - Theophylline - Asthma - Unknown - Nausea
Adenosine antagonist - Vomiting
HDAC2 activation (decreased - Diarrhea
activation of pro-inflamm. TF) - CNS stimulation
- Cardio stimulation - dysrythmias
Selective PDEI - Roflumilast - COPD - Reduced level of adverse effects
- Contraindicated in asthma
Cysteinyl leukotriene - Montelukast - prophylactic use only - Can cause Churg Strauss syndrome
receptor antagonist - Aspirin-induced asthma - Caution in patients with hepatic
- Exercise-induced asthma disease (Cyp3A4 metabolism)
- Chronic asthma
Monoclonal antibody - Mepolizumab - Asthma subgroups with - IL-5 inhibitor
high eosinophils
- Omalizumab - Allergic asthma - IgE specific monoclonal antibody
- Lebrikizumab - Asthma subgroup high in - IL-13 inhibitor
TH2 cells
- Dupilumab - Asthma - Dual IL-4 and IL-13 inhibitor
Selective Toxicity Drugs
NRTI - Zidovudine - HIV - Inhibits viral reverse transcriptase
TKI - Imatinib - Leukemia - Selective BCR-ABL and receptor kinases C-KIT/PDGFR
inhibitor
Dihydrofolate reductase - Methotrexate - Chemotherapy - Inhibits synthesis of folate which stops DNA synthesis - Teratogenic
inhibitor

You might also like