21june2025 135429179
21june2025 135429179
DEPARTMENT OF IMMUNOLOGY
Test Name Result Unit Bio. Ref. Range Method
*Ultrasensitive TSH
ULTRASENSITIVE TSH 3.152 uIU/mL 0.55 - 4.78 CMIA
Comment:
Interpretations(s):
TSH stimulates the production and secretion of the metabolically active thyroid hormones, thyroxine (T4) and triiodothyronine (T3), by interacting with a specific receptor on the thyroid cell surface. The synthesis and secretion of TSH
is stimulated by Thyrotropin releasing hormone (TRH), in response to low levels of circulating thyroid d hormones. Elevated levels of T3 and T4 suppress the production of TSH via a classic negative feedback mechanism. Failure at
any level of regulation of the hypothalamic-pituitary-thyroid axis will result in either underproduction (hypothyroidism) or overproduction (hyperthyroidism) of T4 and/or T3.
Limitations:
T3 and T4 circulates in reversibly bound form with Thyroid binding globulins (TBG), and to a lesser extent albumin and Thyroid binding Pre-Albumin, so conditions in which TBG and protein levels alter such as pregnancy, excess
estrogens, androgens, steroids may falsely affect the T3 and T4 levels. Normal levels of T4 can also be seen in Hyperthyroid patients with: T3 Thyrotoxicosis, hypoproteinaemia or Ingestion of certain drugs. Serum T4 levels in neonates
and infants are higher than values in the normal adult, due to the increased concentration of TBG in neonate serum, TSH may be normal in central hypothyroidism, recent rapid correction of hyperthyroidism or hypothyroidism,
pregnancy, phenytoin therapy. Autoimmune disorders may produce spurious result. Various drugs can interfere with the test result. TSH has a diurnal rhythm so values may vary if sample collection is done at different times of the day.
Recommended test for T3 and T4 is unbound fraction or free levels as it is metabolically active.
TSH levels are subject to circadian variation. The variation is of the order of 50%, hence time of the day has influence on the measured serum TSH concentrations.
Time of sampling or food intake alter TSH levels. Recommended sample for thyroid tests is morning fasting sample (Shriram Mahadevn et al)
Reference Intervals:
T3 (ng/ml) T4 (µg/dL) TSH (µIU/mL)
Age Females Males Age Females Males Age Females Males
1 - 30 Days 0.15 - 2.00 0.15 - 2.10 1 - 30 Days 6.30 - 21.5 5.90 - 21.5 1 - 30 Days 0.72 - 13.1 0.52 - 16.0
1 - 12 Months 0.50 - 2.64 0.95 - 2.75 1 - 12 Months 4.90 - 13.7 6.40 - 13.9 1 - 6 Months 0.46 - 8.10 0.55 - 7.10
1 - 5 Years 1.26 - 2.58 0.80 - 2.53 1 - 3 Years 7.10 - 14.1 7.00 - 13.1 7 – 16 Months 0.36 - 5.80 0.37 - 6.00
6 - 10 Years 1.04 - 2.27 0.96 - 2.23 4 - 6 Years 7.20 - 14.0 6.10 - 12.6 17 Months-5Years 0.46 – 8.10 0.35 – 7.10
11 - 15 years 0.96 - 2.11 0.73 - 1.99 7 - 12 Years 6.10 - 12.1 6.70 - 13.4 6 – 18 Years 0.36 – 5.80 0.37 – 6.00
16 - 18 Years 0.91 - 1.64 0.69 - 2.01 13 -1 5 Years 5.80 - 11.2 4.80 - 11.5 > 18 Years 0.35 – 5.50 0.35 – 5.50
> 18 Years 0.60 - 1.81 0.60 - 1.81 > 15 Years 3.20 - 12.6 3.20 - 12.6 For Pregnant females (As per American Thyroid Association)
First Trimester 0.10 – 2.50
Second Trimester 0.20 – 3.00
Third Trimester 0.30 – 3.00
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DEPARTMENT OF IMMUNOLOGY
Test Name Result Unit Bio. Ref. Range Method
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