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Penile Cancer

Penile cancer is an uncommon type of cancer that affects the penis. It typically presents as a lesion on the glans or prepuce that fails to heal or as an induration. Risk factors include phimosis, HPV infection, and smoking. The growth rate of penile cancer lesions can vary. Staging systems such as Jackson and TNM are used to classify tumors based on size, spread to lymph nodes and distant sites. Treatment may involve surgery, radiation therapy, chemotherapy or a combination depending on staging. Prognosis is related to spread to lymph nodes, with 5-year survival rates ranging from 10-90% depending on extent of nodal involvement.

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Florencia Adys Bennington
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966 views

Penile Cancer

Penile cancer is an uncommon type of cancer that affects the penis. It typically presents as a lesion on the glans or prepuce that fails to heal or as an induration. Risk factors include phimosis, HPV infection, and smoking. The growth rate of penile cancer lesions can vary. Staging systems such as Jackson and TNM are used to classify tumors based on size, spread to lymph nodes and distant sites. Treatment may involve surgery, radiation therapy, chemotherapy or a combination depending on staging. Prognosis is related to spread to lymph nodes, with 5-year survival rates ranging from 10-90% depending on extent of nodal involvement.

Uploaded by

Florencia Adys Bennington
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Penile Cancer

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Trio Wicaksono / 0718011088 Florencya Adys / 0718011058 Idhar Trisna Damayanti / 0818011066

Oleh:

Perceptor:
Dr. Mars Dwi Tjahjo, Sp. U

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Anatomy

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P e n i l e c a n c e r i s u n c

Overview

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P h i m o s i s i s p r e

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P h i m o s i s H P V I n f

Etiology

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P e n i l e c a n c e r s

Pathophysiology

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T h e g r o w t h r a t e s o f

Pathophysiology

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Clinical Manifestation

Penile tumors can originate anywhere on the penis, but most are found on the glans (48%) and prepuce (21%). Typical presentations of penile cancer include a lesion that has failed to heal, a subtle induration in the skin, a small excrescence, a papule, a pustule, a warty growth, a large exophytic growth, or a reddened area on the glans The manisfestation can be a hyperemic area on the glans or near the urethral meatus. They can be exophytic or flat, or an ulcerated lesion may be present. A sensation of itching or burning under the foreskin or an ulceration of the glans are the most common presenting symptoms. Pain is rarely present.
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P e n i l e l e s i o n s c a

Presentation

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Staging
The Jackson classification is as follows: Stage I (A): The tumor is confined to the glans, prepuce, or both. Stage II (B): The tumor extends onto the shaft of the penis. Stage III (C): The tumor has inguinal metastasis that is operable. Stage IV (D): The tumor involves adjacent structures and is associated with inoperable inguinal metastasis or distant metastasis
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The TNM classification of the primary tumor (T) is below. These stages simply relate the presence or absence of nodal and distant metastases.

TX: Primary tumor cannot be assessed. T0: Primary tumor is not evident. Tis: CIS is present. Ta: Noninvasive verrucous carcinoma is present. T1: Tumor invades subepithelial connective tissue. T2: Tumor invades corpora spongiosum or cavernosum. T3: Tumor invades the urethra or prostate. T4: Tumor invades other adjacent structures.
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T h e

W H O

h i s t o p

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N o s p e c i f i c l a b o r a t o

Laboratory Studies

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M R I a n d u l t r a s o n o g r a

Imaging Studies

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P a t i e n t s w h o a r e d i a

Treatment

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T h e p r i m a r y g o a l

Medical Therapy

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R a d i a t i o n t h e r a

Radiation Therapy

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C a n d i d a t e s f o r r a d i a

Radiation Therapy

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A w i d e v a r i e t y

Chemotherapy

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T h e s t a n d a r d o f t

Surgical Therapy

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Prognosis

The prognosis of penile cancer is primarily related to the presence or absence of inguinal node metastasis. Untreated patients with inguinal metastases rarely survive 2 years. Of those with clinically palpable adenopathy and histologically proven metastases, 20-50% are alive at 5 years following inguinal lymphadenectomy An 82-88% 5-year survival rate has been reported when only 1-3 lymph nodes are involved. Patients with 1-2 involved inguinal nodes that do not contain poorly differentiated cancer have a 90% 5-year survival rate. When the nodes are positive, the overall recurrence rate is 80%, and the 5-year survival rate is 10%-15% Powerpoint Templates

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