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Parathyroid Hormone

The document discusses parathyroid hormone (PTH), which is synthesized and secreted by the parathyroid glands. PTH regulates calcium and phosphate levels in the blood by enhancing calcium absorption in the bones and intestines, and reducing phosphate reabsorption in the kidneys. It also increases vitamin D synthesis, which helps absorb calcium. PTH secretion is triggered by low blood calcium levels and helps maintain calcium and phosphate homeostasis and bone physiology.

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Sagar Sharma
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217 views

Parathyroid Hormone

The document discusses parathyroid hormone (PTH), which is synthesized and secreted by the parathyroid glands. PTH regulates calcium and phosphate levels in the blood by enhancing calcium absorption in the bones and intestines, and reducing phosphate reabsorption in the kidneys. It also increases vitamin D synthesis, which helps absorb calcium. PTH secretion is triggered by low blood calcium levels and helps maintain calcium and phosphate homeostasis and bone physiology.

Uploaded by

Sagar Sharma
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Sagar Sharma Roll no.

15

Hormones

are the organic substances produced by the endocrine glands, secreted into the blood stream to control different activities. PTH is synthesized and secreted by the parathyroid gland which lie posterior to the thyroid glands. It is the protein hormone .

Regulation of serum calcium It enhances the release of calcium from the large reservoir contained in the bones. It enhances active reabsorption of calcium and magnesium from distal tubules and the thick ascending limb. It enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D.

Regulation of serum phosphate


PTH

reduces the reabsorption of phosphate from the proximal tubule of the kidney. On the other hand it balances by uptake of phosphate from the intestine and bones into the blood.

Vitamin D synthesis PTH increases the activity of 1-hydroxylase enzyme which helps to form active form of vitamin D.

when

blood calcium levels drops , calciumsensing receptors in the parathyroid gland are activated to release hormone into the blood. It takes part in the control of calcium and phosphate homeostasis, as well as bone physiology.

PTH

increases intestinal calcium absorption by activating vitamin D, and promotes calcium uptake by the kidneys. It balance the phosphate regulation by reducing its reabsorption from PCT and uptake from intestine .

A simple flowchart to show role of PTH

Hyperparathyroidism Hypoparathyroidism Pseudohypoparathyroidism caused due to defect in PTH receptor.

www.wiki.answers.com www.wikipedia.org www.vivo.colostate.edu www.webmd.com Biochemistry 3rd edition

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