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Tablet Coating

This document discusses different types of tablet coatings, including sugar coating, film coating, press coating, and enteric coating. It explains the purposes and processes for each type. Sugar coating involves multiple stages to seal the core and apply color and polish. Film coating sprays a polymer solution onto tablets to form a thin, uniform coating. Important parameters for the film coating process are also outlined. Enteric coatings are used for drugs that could be unstable or irritating in the stomach.

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Zeeshan Khan
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181 views

Tablet Coating

This document discusses different types of tablet coatings, including sugar coating, film coating, press coating, and enteric coating. It explains the purposes and processes for each type. Sugar coating involves multiple stages to seal the core and apply color and polish. Film coating sprays a polymer solution onto tablets to form a thin, uniform coating. Important parameters for the film coating process are also outlined. Enteric coatings are used for drugs that could be unstable or irritating in the stomach.

Uploaded by

Zeeshan Khan
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
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Tablet Coating

Why coat tablets?


Types of coatings
sugar coating
film coating
press coating (compression coating)
B. Amsden 1 CH !!"
Sugar Coating
stages in#ol#ed$
sealing of tablet core
subcoating
smoothing
colouring
polishing
printing
B. Amsden % CH !!"
Film Coating
&n#ol#es spraying a solution of polymer ' pigments '
plastici(ers onto a rotated) mi*ed tablet bed to form a
thin) uniform film on tablet surface.
materials
polymers
sol#ents
plastici(ers
colorants
B. Amsden + CH !!"
Coating Process
coating pans
B. Amsden ! CH !!"
The Coating Process
B. Amsden CH !!" ,
Film Formation
late* particles dispersed
in a-ueous phase
formation of thin film .ith
.ater e#aporation through film
continuous film
B. Amsden / CH !!"
Air Flow
B. Amsden CH !!" 0
Coating Process
fluid beds
B. Amsden 1 CH !!"
Important Processing Parameters
inlet and bed temperatures
relati#e humidity
atomi(ation air pressure
li-uid spray rate
droplet si(e
drying time
B. Amsden 2 CH !!"
Coating Problems
pic3ing4chipping
roughness
stic3ing
film crac3ing4peeling
B. Amsden 1" CH !!"
Normal Coating
5escription
6econstitution
le#el
A#erage
.eight
gain
Application e*amples
H78C based
A-ueous
system
119 to 1,9 %., 9
H78C based
:rganic
sol#ent
system
,9 %.,9
H78C based
A-ueous4
:rganic
;ol#ent4
Hydro
Alcoholic
system
A-ueous 119
:rganic ;ol#ent
,9
Hydro Alcoholic
29
%.,9
7<A based
A-ueous
system
%"9 to %,9 %.,9
Amo*ycillin) A(ithromycin) Atenolol)
Amlodipine) Amitriptyline) Ampicilin
Ciproflo*acin) Cephadro*il )
Cimitidine) Calcium Tablets) Citri(ine
) Chloro-uine 7hosphate)
Clarithromycin) rythromycin)
=errous =umarate) =amotidine)
=errous ;ulphate) &buprofen)
&ndapamine) >osartan 7otassium)
>e#amisole) 8ethyl?5opa)
8etronida(ole'Tinida(ole)
8etronida(ole) 8ethyl Coblamine)
8efenamic Acid) 8etoprolol Tartrate)
@orflo*acin) @ifidipine)
@orflo*acin'Tinida(ole) :flo*acin)
7aracetamol) Auinine ;ulphate)
6o*ythromycin) ;ecnida(ole)
;ildenafil Citrate) Trimeta(idine)
Tinida(ole) Tinida(ole?5o*ycycline)
Tinida(ole ' Tetracycline) <erapamil
B. Amsden 11 CH !!"
Enteric-coated
Coating resists dissolution or disruption in stomach but not in
intestines. Bsed for drugs that are unstable) irritating to stomach
B. Amsden 1% CH !!"
5escription
6econstitution
le#el
A#erage
.eight
gain
Application CC e*amples
:rganic nteric
Coating system)
Cellulose Acetate
7hthalate based
, 9 1 9
A-ueous coating
system D :rganic
enteric coating
system. Hydro*y
7ropyl 8ethyl
Cellulose 7hthalate
based system.
:rganic$ ,9
A-ueous$ 1"9
1 9
8ethacrylic acid
copolymer type ECE
B;74@= based
system
A-ueous %"9
Hydro Alcoholic
1"9
:rganic ;ystem
1"9
29
Aspirin) Bisacodyl
5iclofenac ;odium
5o*ylamine ;uccinate
Farlic Tablets) :mepra(ol)
7entapra(ole)
7ento*yfyline) 6abepra(ol )
;errosipeptadise
Press Coating
Bse of compression to form coat around a pre?formed core.
Bsed mainly to separate chemically incompatible materials
also dual release patterns possible
B. Amsden 1+ CH !!"

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