Presented By: Mr. Hiren Patel Guided By: Mr. Mohmadmoin K. Modasiya M.Pharm
Presented By: Mr. Hiren Patel Guided By: Mr. Mohmadmoin K. Modasiya M.Pharm
Type of Examples
Humectant
Inorganic Calcium chloride (not used now due to compatibility
problems)
Metal organic Sodium lactate (used in sunscreen lotions)
Organic Polyethylene glycol, Propylene glycol, glycerol,
sorbitol, mannitol, glucose
• SURFACTANTS: -
– Surfactants lower one or more boundary tensions
at interface in the system. one common feature of
surfactant is that they all are amphipathic
molecules containing a hydrophobic part & a
hydrophilic part. Used in cosmetics to impart
following functions.
DETERGENCY, WETTING, FOAMING,
EMULSIFICATION, SOLUBILIZATION
Type of Examples
surfactant
1.Anionic Fatty acid soaps, alkyl sulphates, alkyl sulphonates,
polyethylene glycol ester,alkyl ether sulphates
taurines,sarcosinates etc.
2.Cationic Alkyl trimethyl ammonium salts, Dialkyl dimethyl
ammonium salts alkyl pyridinium salts, quaternised
diamine salts.
3. Non ionic Alkanolamides,alkyl polyglycol ether, thioethers,
alkyl polyethyleneimine amides.
ANTI
Allantoin (hand cream & lotion) Cade
INFLAMMATORY
oil(eczema& psoriasis),Calamine
AGENTS
SUNSCREEN PABA, Vitamin C, Quinine salts
AGENTS Coumarin derivatives
ANTIDANDRUFF Selenium, cadmium sulphide, ZPTO
COSMETICS FOR SKIN
• Skin cream
• Lotion
• Face powder & Compacts
• Skin colorants
• Body powder
• Face pack & Masks
• Bath Preparations (bath salt,oil,powder,foam)
Functions of Skin
• Regulation of body temperature.
• Protection.
• Sensation.
• Excretion.
• Immunity.
• Blood reservoir.
• Synthesis of Vitamin D.
• Emulsified type:-
Common Ingredients:-
Oil phase…………………..Spread easily
Waxes……………………..Give appropriate thixotropy
Emollient material…………likes cetyl alcohol, spermaceti,
lanolin Water phase with preservative
Beeswax Borax type
• These contain high percentage of mineral oil. These are o/w type.
• After the cream is being rubbed into the skin sufficient quantity of
water evaporates to impart a phase inversion to the w/o type.
Ingredients Quantity
Bees wax 2 gm
Borax 2 gm
Almond oil 50 gm
Rose water 35.5 gm
Lanolin 0.5gm
preservative and perfume q.s
NIGHT & MASSAGE CREAM
• The mostly have a moisturizing & a nourishing effect of
affected skin. These also contain vitamins and hormones
basing on the application. This cream give better look to
the skin and prevent dryness.
Ingredients Quantity
Mineral oil- 1gm
Borax 1gm
Petroleum jelly- 8gm
Water 35gm
White bees wax- 15gm
Paraffin wax 1.0gm
Lanolin 2gm
Perfume & preservative- q.s
VANISHING CREAM
Ingredients Quantity
• These are named so as
Stearic acid- 15gm
they seem to vanish when
applied to the skin. Glycerin 5gm
• High quantity of stearic KOH 0.5 gm
acid as oil phase used.This
provides an oil phase Water 75.82 gm
Perfume------0.5gm Perfume------0.6gm
COMPACT FACE POWDER
• It is a dry powder
Type of binder Examples
which has been
compressed into a 1) Dry binder Zn/Mg.stearate
Ingredients Quantity
Zinc oxide 50 gm
Zinc stearate- 50 gm
Chlorhexidine diacetate- 3 gm
Light magnesium carbonate 100 gm
Talc 797 gm
Perfume 0.2 mL
BODY POWDER
• It consists of mainly talc, with small portion of a metallic
stearate, precipitated chalk, magnesium carbonate(light).
• Boric acid act as antiseptic.
Ingredients Quantity
Talc 75 gm
Aluminum stearate 4 gm
Colloidal Kaolin 10 gm
Boric acid 0.3 gm
Colloidal silica 5 gm
Perfume 0.7 gm
Evaluation of Powder
• Shade control and lighting
• Dispersion of colour
• Pay-off
• Pressure testing
• Breaking test
• Flow property
• Particle size and abrasiveness
• Moisture content and limits for colour
SKIN COLORANTS
A) LIPSTICKS
These are basically dispersions of coloring matter in a base
consisting of a suitable blend of oils, fats, waxes, suitably
perfumed and flavored, moulded in the form of a stick.
B) ROUGE
These are the cosmetics preparations used to apply a color
to the cheeks. The color may vary from the palest of pinks
to the deep blue reds .The tint or color may be achieved
using water insoluble colors such as iron oxides and certain
organic pigments or by using water soluble organic colors
which actually stain the skin.
LIPSTICK
• Ideal character of lipstick includes:-
– Should cover the lips adequately with some gloss and last for
long time.
– It should make the lips soft.
– The film must adhere firmly to the lips without being brittle.&
tachy.
– Should have high retention of color intensity without any
change in shade.
– Should be completely free from grittiness & free from drying.
– Nonirritating to the lips.
– Desirable degree of plasticity & have a pleasant odor and flavor.
Evaluation Castor oil
Lanolin
54 gm
11 gm
(anhydrous)
Candeilla wax 9 gm
• Melting point
Isopropyl 8 gm
• Breaking point myristate
• Thixotropy character White beeswax 5 gm
• Force of application Carnauba wax 3 gm
Ozokerite wax 3 gm
• Aging stability Eosin 2 gm
• Perfume stability Lakes 5 gm
• Oxidative stability Rose flavor q.s
Antioxidant q.s
• Surface anomalies preservative q.s
• Accelerated stability test
SKIN ROUGE
Powder Rouges Stick Rouge
Talc………………………….40 Carnauba wax…………………3
Zinc oxide…………………..10 Candelilla………………………6
Magnesium carbonate……….20 Ozokerite………………………1.5
Pigment……………………..14 Bees wax………………………1.5
Lanolin……………………...30 Hexadecyl stearate……………10
Perfume……………………..2 Isopropyl myristate…………….8
Castor oil……………………….65
BHA……………………………..0.02
Color……………………………5
Emulsion cream rouge (vanishing type) Liquid rouge
Stearic acid…………………….15 (A) Iso stearic acid…………….0.02
Potassium hydroxide………….0.5 Mineral oil………………….30
Sod. Hydroxide………………..0.18 Iso propyl myristate………..5
Glycerin………………………..8 Colloidal silica……………..1
Water…………………………..76 Color………………………...3
Pigment, Perfume & (B) Water……………………..48.3
Preserative……………………q.s Triethanolamine……………4
Perfume…………………….0.2
Evaluation
• Melting point
• Colour dispersion
• Aging stability
• Container compatibility
• Sedimentation of liquid rouges
COSMETICS FOR HAIR
• Includes following type of preparations:-
– Shampoo
– Hair tonics & Conditioners
– Hair colorants and hair color remover
– Hair grooming preparations
– Depilatory & Epilatory
– Shaving soaps & creams
– Hair wave sets & lacquers ,rinses
SHAMPOO
• Ideal characters of a shampoo:-
– Should effectively and completely remove the dust, excessive
sebum.
– Should effectively wash hair.
– Should produce a good amount of foam
– The shampoo should be easily removed by rinsing with water.
– Should leave the hair non dry ,soft, lustrous with good,
manageability.
– Should impart a pleasant fragrance to the hair,.
– Should not make the hand rough and chapped.
– Should not have any side effects or cause irritation to skin or eye.
• Composition of shampoo:-
• Evaluation of shampoos :
– Various physical properties and performance characteristics should be studied.
These are foam formation and foam stability,rheology, of the products, nature
of foam, effect of the shampoo on the hair and its character etc.
– Effect on skin and eye : This can be done by applying it on animals. Irritation
on skin can be studied by applying it on skin and observing the effects on skin.
CONDITIONERS
Ingredients Quantity
• These are the preparations
used after shampooing to Steryl alcohol 0.6 gm
render the hair more lustrous, Glyceryl 0.2 gm
easy to comb, and free from monostearate
static electricity when dry. Sodium chloride 0.2 gm
Conditioners are usually based Benzalkonium 1.5 gm
chloride
on cationic detergents and
Water 97.5 gm
fatty materials like lanolin, or
mineral oil. Colour q.s.
Perfume q.s.
Evaluation
• Antiseptic property
• Stability test
• Sensitivity test
HAIR COLORANTS
• These are used either to hide gray hair or to change the color of the hair .
Hair dyes are divided into
1) Vegetable
Example is Henna
2) Metallic
Example:- Lead dyes, Bismuth dyes, Silver dyes, Copper, nickel, cobalt salts
Formula:- (Lead dyes)
Precipitated sulphur……………….1.3%
Lead acetate………………………..1.6%
Glycerine…………………………….9.6%
Rose water………………………….87.5%
3) Synthetic organic dyes
They are of two types.
a) Semipermanent dye.b) Permanent dyes
Thyoglycolic acid……50% Paraphenylene diamne dye
NH3 solution(PH 9.2)…100%
Evaluation
• Sensitization test : This can be done on the
animal skin by applying dyestuff or the
preparation and observing the effect on the
skin.
• Long term toxic effect : This is also neccesory
to evaluate the long-term effect. This can also
be done on animal.
HAIR GROOMING AIDS
• These are important group of cosmetics which are used both by
men and women to keep their hair in order for good looking,
&enhance overall appearance.
• Types:-
– Brilliantines & Hair oils
– Hair setting lotions
– Hair creams
– Hair lacquers or sprays
• Evaluation :
– Stability of the ingredients.
– Physical stability.
– Rheology.
DEPILATORIES
• These are the preparations that remove superfluous hair by chemical
breakdown. This removes hair at the neck of the hair follicle and thus
has advantage over razor shaver which removes hair on a level with
the surface of epidermis.
• INGREDIENTS :- includes
1. Inorganic sulphates ( Sod, calcium, barium sulphide,Strontium
sulphide)
2. Thioglycollates: - (Calcium.thioglycollate & Lithium thioglycollate)
3. Stannites: - sodium stannite
4. Enzymes:-Keratinase (3-4%)
5. Humectant: - Glycerol,Sorbitol ,Propylene glycol
Name of ingredient Amount
1.Strontium 20.0 gm
sulphide
2.Talc 20.0gm
3.Methyl cellulose 3.0 gm
4.Glycerin 15.0 gm
5.Water 42.0 gm
6.Perfume q.s
7. Preservative q.s
• Evaluation :
– Estimation of hair removing agents: As high concentration of the
chemical hair remover may be dangerous, it is necessary to measure
the quantity. It can be done by any instrumental chemical analysis.
– Toxicity test: The test can be done on animal. For this purpose
rabbit can be used.
– Stability.
SHAVING PREPARATIONS
• Type
• Ued before shaving
• Used after shaving
Preparations before shaving includes
1) Lather shaving creams
2) Brushless shaving cream
3) Shaving soaps (solid, cream)
4) Aerosol preparation
Preparation after shaving is
Aftershave lotion
Brushless shaving cream LATHER SHAVING CREAM
Ingredients Amount
Butyl acetate 15 gm
Perfume q.s
CUTICLE REMOVERS AND SOFTENERS
• Cuticle preparations either soften or remove the cuticles.
• Formula
Lanolin 4.0 gm
Beeswax 1.0 gm
Petroleum jelly 95.0 gm
Perfume q.s.
• Evaluation parameter :
– Stability of the products, rheology, film characters etc. are some tests
which are required to be done depending on the type of the products
COSMETICS FOR EYES
• Includes following preparations
– Eye shadow
– Mascara
– Eyebrow pencil
– Eye cream
– Eye liners
– Kajal
EYE SHADOW
• Give a back ground of color to the eye
• Formulated as cream, liquid, powder or stick.
• Ultramarine(20 part)& Ti02 --- (BLUE)
• Iron oxide(30 part) &Ti02 (5 part)-- (BROWN)
Ingredients Amount
petroleum jelly 47.5 gm
Liquid lanolin 4.5 gm
Bees wax 4.5 gm
Micro 8.5 gm
crystalline wax
Isopropyl myristate 35 gm
EYE LINER
• Types
1. Pencil type
2. Liquid type (suspension in a base containing film forming material)
3. Cake eye liners
Ingredient Amount
Bees wax 25%
Ozokerite 25%
Butyl stearate 8%
Lanolin 2%
Castor oil 25%
Mineral oil 15%
Perfume q.s
Antioxidant q.s
MASCARA
• Black pigmented preparation for applying to eye
lashes or eye brows ,it darkens the eye lashes &
gives an illusion of their density and length.
• Type:- Cake , Cream , Liquid
Formulation of liquid mascara
Carbon black 55 %
Coconut oil sodium soap 25%
Palm oil –sodium soap 22.5%
TOOTH PASTES
• Tooth pastes are most popular valuable and widely
used preparations for cleansing the teeth. It has largest
share of dental cleansing and care preparations.
• Tooth pastes are preferred over other dental
preparations because of following reasons.
– Easy to take and spread on the tooth brush
– No spillage or wastage
– Attractive consistency
– Proper distribution in mouth
– Available in wide varieties
• Formulation
– The binder is premixed with solid abrasive, which
is then mixed with the liquid phase, containing
humectant, preservative and sweetener into a
mixer. After formation of homogeneous paste, the
flavour and detergent are added, mixed, milled
deairated and tubed.
TOOTH POWDERS
• Tooth powders are oldest and simplest
preparations. Over the years their market share
has been reduced due to popularity of pastes,
but steel they have a considerable market share.
• The main problems encountered with powders
are-
– Floating of powder in air during manufacturing.
– Formation of cake on storage
– Uneven distribution in mouth
• General procedure for manufacture
– This is done by simple mixing
– First ingredients of small quantity are premixed
and then mixed with other ingredients.
– Ribbon type or agitator type of mixer are used.
– Flavour can be sprayed on to the bulk or can be
premixed with part of some abrasive.
EVALUATION OF SOLID DENTAL PRODUCTS