MR Class Day Presentation
MR Class Day Presentation
From Brain
Development To
Neurodegenerative
Protection
The Well-Rounded Walnut
Walnuts have a rich matrix of bioactive compounds
Fatty acids and antioxidants
Omega-3s, polyphenols, carotenoids, vitamins C & E
This mix of compounds gives walnuts the power to
reduce oxidative stress and inflammation + helps
maintain neuronal membrane integrity and attenuate
protein aggregation
Omega-3s
Polyunsaturated Fatty Acids (PUFA)
Alpha-linolenic acid (ALA)
Eicosapentaenoic acid (EPA)
Docasahexaenonic acid (DHA)
Precursors to prostaglandins and thromboxanes
Highly concentrated in the brain and abundant within
neuronal membranes
Omega-3s in Brain Development
DHA is the most prevalent fatty acid in phospholipid
membranes of the brain
Low consumption of EPA and DHA is linked to delayed
brain development in babies and increased risk for
Alzheimer's later in life
Aging and Metabolic Effects of Brain Health
CNS Demands
One-Fourth of
all O2
Dystrophy and
Generation of
Death of Brain
Free Radicals
Cell
Aging Impacts
Homeostasis
Omega-3s and the Aging Brain
The Walnuts for Healthy Aging Study (WAHA)
A 2 year study examining the effects of walnut
consumption on cognitive function
Participants consumed 30-60g of walnuts per day
Cognitive testing at base line and at end of study
The rapport built by the dietitian with the participant
during the periodic scheduled visits was critical to retain
participants for the entire length of the study
WAHA continued.
PUP QUIZ!
Beets &
Cardiovascular
Health
Say N-O To
Endothelium
Dysfunction
Cardiac and Vascular Endothelium
A thin membrane that lines the inside of the heart and blood
vessels
Serves as a semipermeable barrier
A healthy endothelial protects against atherosclerosis
Releases biologically active substances in response to physical,
chemical, and humoral changes
Modulates the tone of underlying vascular smooth muscle
Maintains a non-adhesive luminal surface
Mediates hemostasis, cellular proliferation, and inflammatory
and immune mechanisms in the vascular wall
Nitric Oxide (NO)
Reduced secretion of NO
Blood vessels to become slow to dilate and slow to
increase blood flow, and can become constricted
instead
Atherosclerosis and common cardiovascular risk
factors such as high blood pressure, diabetes, high LDL
cholesterol, smoking, unhealthy diet and overweight
can cause abnormal endothelial function
Conventional L-arginine/NO synthesis
pathway
Nitrate Nitrite Nitric Oxide
Research
250 mL of beetroot juice
Reduced blood pressure measured by 3 different methods
Clinical by 7.7/5.2 mmHg
24h Ambulatory by 7.7/5.2 mmHg
Home by 8.1/3.8 mmHg
Endothelial function improved by ~20% and arterial stiffness was reduced
Carotenoids To The
Rescue!
Carotenoids: Lutein & Zeaxanthin
The main pigments found in the macula of the human retina
Protect the macula from damage by blue light
Improve visual acuity
Scavenge harmful reactive oxygen (antioxidants)
Their role in eye health has been well established from
epidemiological, clinical and interventional studies
Reduce cataract development and age-related macular
degeneration (AMD)
Age-Related Diseases of the Eye
Cataracts - clouding of the normally clear lens of the eye