The Human Immune System

Video
 What is the immune system?
• The body’s defense against disease causing
organisms, malfunctioning cells, and
foreign particles
 The First Line of Defense
- The dead, outer ~Skin~
layer of skin, known
as the epidermis,
forms a shield
against invaders and
secretes chemicals
that kill potential
invaders
- You shed between
40 – 50 thousand
skin cells every day!
 The First Line of Defense
~Mucus and Cilia~
- As you breathe in,
foreign particles and
bacteria bump into
mucus throughout
your respiratory
system and become
stuck
- Hair-like structures
called cilia sweep this
mucus into the throat Don’t swallowed bacteria have a
for coughing or good chance of infecting you?
swallowing
 The First Line of Defense
~Saliva~
What’s the first thing you do when you cut
- Saliva contains manyyour finger?
chemicals that break down
bacteria
- Thousands of different types
of bacteria can survive these
chemicals, however
 The First Line of Defense
~Stomach Acid~
- Swallowed bacteria are
broken down by incredibly
strong acids in the stomach
that break down your food
- The stomach must produce a
coating of special mucus or
this acid would eat through
the stomach!
 Think of the human body as a
hollow plastic tube…

The food is digested within the hole in the

tube, but it never actually enters into the
solid plastic material.
Tube inner surface Tube outer surface Plastic interior
~Digestive System~ ~Skin~ ~Body~
 Escherichia coli
is common and plentiful in all of our
digestive tracts. Why are we all not
sick?
- These bacteria are
technically outside the
body and aid in digesting
material we cannot
- Only if E.Coli are
introduced in an unnatural
manner can they break
through the first line of
defense and harm us
 The Second Line of Defense
~White Blood Cells~
- If invaders actually
get within the body,
then your white
blood cells (WBCs)
begin their attack
- WBCs normally
circulate throughout
the blood, but will
enter the body’s
tissues if invaders
are detected

Video
 White Blood Cells
~Phagocytes~
• These white blood cells are
responsible for eating
foreign particles by
engulfing them
• Once engulfed, the
phagocyte breaks the
foreign particles apart in
organelles called ________
Lysosomes
Where could invaders
hide from phagocytes?
 Viruses
Viruses enter body cells, hijack their organelles, and
turn the cell into a virus making-factory. The cell
will eventually burst, releasing thousands of viruses
to infect new cells.

Cell before infection… …and after.

 The Second Line of Defense
~Interferon~
- Virus-infected body
cells release
interferon when an
invasion occurs
- Interferon – chemical
that interferes with the
ability to viruses to
attack other body cells

What happens to already

infected cells?
 White Blood Cells
~T-Cells~
• T-Cells, often called
“natural killer” cells,
recognize infected human
cells and cancer cells
• T-cells will attack these
infected cells, quickly kill
them, and then continue to
search for more cells to kill
 The Second Line of Defense
~The Inflammatory Response~
- Injured body cells release
chemicals called
histamines, which begin
inflammatory response
- Capillaries dilate
- Pyrogens released, reach
hypothalamus, and
temperature rises
- Pain receptors activate
- WBCs flock to infected area
like sharks to blood
 Two Divisions of the Immune
System
- The efforts of the WBCs known as
phagocytes and T-cells is called the cell-
mediated immune system.
- Protective factor = living cells
- Phagocytes – eat invaders
- T-cells – kill invaders
 Two Divisions of the Immune
System
• The other half of the immune system is
called antibody-mediated immunity,
meaning that is controlled by antibodies
• This represents the third line of defense in
the immune system
 The Third Line of Defense
~Antibodies~
- Most infections never make it
past the first and second levels
of defense
- Those that do trigger the
production and release of
antibodies
- Proteins that latch onto, damage,
clump, and slow foreign particles
- Each antibody binds only to one
specific binding site, known as an
antigen
 Antibody Production
- WBCs gobble up invading
particles and break them up
- They show the particle
pieces to T-cells, who
identify the pieces and find
specific B-cells to help
- B-cells produce antibodies
that are equipped to find
that specific piece on a new
particle and attach

Video - 1:58
 Immunity
- New particles take longer
to identify, and a person
remains ill until a new
antibody can be crafted
- Old particles are quickly
recognized, and a person
may never become ill from
that invader again. This
person is now immune.
 What is immunity?
- Resistance to a disease causing organism or
harmful substance
- Two types
- Active Immunity
- Passive Immunity
 Active Immunity
- You produce the antibodies
- Your body has been exposed to the antigen in
the past either through:
- Exposure to the actual disease causing antigen – You
fought it, you won, you remember it
- Planned exposure to a form of the antigen that has
been killed or weakened – You detected it,
eliminated it, and remember it

What is this second type of

exposure called?
 Vaccine
• Antigens are deliberately introduced into the
immune system to produce immunity
• Because the bacteria has been killed or weakened,
minimal symptoms occur
• Have eradicated or severely limited several
diseases from the face of the Earth, such as polio
and smallpox
 How long does active immunity
last?
• It depends on the antigen
• Some disease-causing
bacteria multiply into new
forms that our body doesn’t
recognize, requiring annual
vaccinations, like the flu
shot
• Booster shot - reminds the
immune system of the
antigen
• Others last for a lifetime,
such as chicken pox
 Think the flu is no big deal?
- Think again…
- In 1918, a particularly
deadly strain of flu,
called the Spanish
Influenza, spread across
the globe
- It infected 20% of the
human population and
killed 5%, which came
out to be about 100
million people
 Do we get all the possible
•
vaccines
Although the Center for
we can?
Disease Control (CDC)
recommends certain vaccines,
many individuals go without
them
• Those especially susceptible
include travelers and students
• Consider the vaccine for
meningitis, which is
recommended for all college
students and infects 3,000
people in the U.S., killing 300
annually

Link
 Passive Immunity
• You don’t produce the antibodies
– A mother will pass immunities
on to her baby during pregnancy
- through what organ?
– These antibodies will protect the
baby for a short period of time
following birth while its immune
system develops. What Placenta
endocrine gland is responsible
for this?
– Lasts until antibodies die

Why doesn’t the mother just

pass on the WBCs that
Thymus
“remember” the antigens?
Immune Disorders
~Allergies~
- Immune system mistakenly
recognizes harmless foreign
particles as serious threats
- Launches immune response,
which causes sneezing, runny
nose, and watery eyes
- Anti-histamines block effect of
histamines and bring relief to
allergy sufferers
 Aquired Immune Deficiency Syndrome

• Caused by the Human

Immunodeficiency Virus
• Discovered in 1983
• Specifically targets and kills
T-cells
• Because normal body cells are
unaffected, immune response
is not launched
 AIDS
~The Modern Plague~
- The HIV virus doesn’t kill
you – it cripples your
immune system
- With your immune system
shut down, common diseases
that your immune system
normally could defeat
become life-threatening
- Can show no effects for
several months all the way
up to 10 years
 AIDS
~The Silent Spread~
• Transmitted
by sexual
contact, blood
transfusions,
contaminated
needles
• As of 2007, it
affects an
estimated 33.2
million people