Dictionary of Weighing Terms
Dictionary of Weighing Terms
• Internal Adjustment
Weights & isoCAL
• Real Time Clock
• Alpha Numeric Data
Input
• Bar Code Scanner
Connectivity for sample
ID’s
Typical GLP/GMP Compliant
Printout
10.04.2005 11.45.23
Sartorius AG
Model ME235S
Ser. no. 60419914
Ver. no. 01-30-01
ID QC Lab 22
SQmin 45mg
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Internal Calibration
Start: isoCAL/temp
Diff. + 0.00007g
Internal adjustment completed
Diff. + 0.00000g
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10.04.2005 11.46.23
Name:
Calibration and Daily use of
Balances
• Terminology - How to understand
specifications
• Weight Units
• Basic Principle of an Electronic Balance
• Care in the use of balances
• Hazards to avoid
Understanding The Technical data:
Readabilit
y
± 0.01g
x= average weight
s= standard deviation
± 0.03g
x= average weight
s= standard deviation
(500+)
g
0.01g
200.0000g/1,000,000
= 0.0002g
Sensitivity Drift –with 5 place
balances
• ± 1x10-6 per degree Celsius or:
• ± 1 part per million per degrees
Celsius
200.00000g/1,000,00
0
= 0.00020g
Sensitivity Drift
10.00000g/1,000,000
= 0.00001g
Response Time
• Balance table 1m x 1m
• Raise one side 5mm
• Before 200.00000g
• After 199.99850g
• Difference 0.00150g
Errors - changes in regional gravity
• Organisation International
de Metrology Legale
• Specifies
Design, Material, Surface
Quality, Tolerances,
Markings, & Manufacture
• RI 111
Classes of Calibration Weights
• Equipment Qualification
EQ
• What is it?
• Why?
• Description!!
Installation Qualification or IQ
• Completeness Check
• Record Serial #
• Software Version
• Location
• Accessories
• Appropriate Safety
Standards
Operational Qualification or
IQ
• Testing against
Specification
• Subject to Environmental
conditions
• Testing Functionality of
Balance
• Essentially a Full
Calibration
Performance Qualification PQ
• Pharmaceutical Laboratories
• All measurements to be
made with intended
accuracy
• 0.1% maximum uncertainty
What is Uncertainty?
• Operators
• Off Centre Loading
• Occasional Poor conditions
• Occasional Drafts
• Occasional Vibration
Systematic Errors
USP statement:
SD x 3 /sample weight ≤ 0.001
0.3/300 = 0.001
Measurements to 0.1% max Uncertainty
• Even easier
• Minimum weight is calculated:
• Measured SD x 3 x 1000
• 0.1mg x 3 x 1000
• 300mg
Typical Theoretical minimum
weights
Readability Typical Minimum
weight
• 1mg balance 3000mg
• 0.1mg balance 300mg
• 0.01mg balance 45mg
• 1µg balance 3mg
Determination of Uncertainty with 10g mass
• Reproducibility ≤ 0.07mg
• Temp drift 5C
• 10g x 1 x 10-6 x 5C = ≤ 0.05mg
• Max linearity = ≤ ± 0.15mg
• E2 calibration error = ≤ ± 0.015mg
• (200g max 0.3mg)
Determination of Uncertainty with 10g
mass
According to the Law of
Propagating errors
Sartorius
Sartorius
mg
change corrected
U = 0.21mg
Determination of Uncertainty with10g
sample