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Homeostasis

This document discusses homeostasis and hemostasis, which is the physiological process that prevents bleeding after vascular injury and maintains blood circulation. It outlines the primary and secondary phases of hemostasis, which involves platelet adhesion, aggregation, and formation of a hemostatic plug in response to vascular injury. The coagulation cascade is also summarized, including the intrinsic and extrinsic pathways that generate thrombin and ultimately lead to fibrin formation and cross-linking to form a stable blood clot. Key coagulation factors involved are also listed. The fibrinolysis process is briefly described, involving the conversion of plasminogen to plasmin which degrades fibrin clots.

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55 views

Homeostasis

This document discusses homeostasis and hemostasis, which is the physiological process that prevents bleeding after vascular injury and maintains blood circulation. It outlines the primary and secondary phases of hemostasis, which involves platelet adhesion, aggregation, and formation of a hemostatic plug in response to vascular injury. The coagulation cascade is also summarized, including the intrinsic and extrinsic pathways that generate thrombin and ultimately lead to fibrin formation and cross-linking to form a stable blood clot. Key coagulation factors involved are also listed. The fibrinolysis process is briefly described, involving the conversion of plasminogen to plasmin which degrades fibrin clots.

Uploaded by

Lely Sharma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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HOMEOSTASIS

HEMOSTASIS
Proses fisiologis yg seimbang :

 mencegah perdarahan >>>


(setelah perlukaan vaskuler)

 mempertahankan sirkulasi
(dg menjaga darah tetap cair)

Trombosis Perdarahan

KOAGULASI HEMOSTASIS FIBRINOLISIS

Perdarahan Trombosis
diah 3
SECONDARY HEMOSTASIS

PRIMARY HEMOSTASIS
PROSES HEMOSTASIS
Vascular
injury
Exposure of colagen
Tissue factor
Platelet adhesion
&
Serotonin Release reaction Release of
Platelet phopholipid

TX2, ADP

Vasoconstriction Platelet
Coagulation
aggregation
cascade

Primary
Blood flow ↓
Hemostatic plug Thrombin

Secondary hemostatic plug


Fibrin
(stable hemostatic
diah plug)
Surface contac :
HMWK JALUR KOAGULASI DARAH
Prekalikrein
XII XIIa
XI XIa TF + VIIa
IX IXa X JALUR EKSTRINSIK
JALUR INTRINSIK+ Ca 2+
Ca 2+
VIII VIIIa
Xa + Va + phospholipid

XIII
II (prothrombin) Ca 2+ IIa (thrombin)
PL

XIIIa

I (fibrinogen) Fibrin Cross-


linked
diah
fibrin6
FAKTOR KOAGULASI PLASMA
Faktor Nama

I Fibrinogen
II Prothrombin
III Tissue thromboplastin
IV Calcium
V Proaccelerin (labile factor)
VII Proconvertin (stable factor)
VIII Antihemophilic A factor
IX Antihemophilic B factor
X Stuart factor
XI Plasma thromboplastin antecedent
XII Hageman factor, contact factor
XIII Fibrin stabilizing factor
JALUR FIBRINOLISIS

PLASMINOGEN
Aktivator :
o intrinsik : Anti aktivator :
F.XII, kinin, trombin, o C-1 Esterase inhibitor
urokinase o PAI (plaminogen activator
oEkstrinsik : inhibitor )
t-PA, excercise, stress
oTerapeutik :
streptokinase
PLASMIN
Antiplasmin :
o α2 antiplasmin
o α2 makroglobulin

FIBRIN FIBRIN DEGRADATION PRODUCTS


(FDP)
D-Dimer

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