Lecture 4 Metallic Biomaterials
Lecture 4 Metallic Biomaterials
1
Metallic biomaterials
Objective:
- Describe the concept of metallic biomaterials used in various applications
Outline:
– Metals
– Polymers, synthetic and natural
– Ceramics
– Composites
3
METALS
• Definition: Inorganic materials possessing non-
directional metallic bonds with high highly
mobile electrons / any of a category of
electropositive elements that usually have a
shiny surface
4
Metals
• Load bearing implants and internal fixation
devices;
• When processed suitably contribute high
tensile, high fatigue and high yield
strengths;
• Low reactivity;
• Properties depend on the processing
method and purity of the metal.
5 5
Metals for Implantation
• Must be corrosion resistant
• Metals may fail due to: GALVANIC SERIES OF METALS AND ALLOYS IN
SEA WATER
Corrosion
Fracture
Wear
Yielding
Loosening
Infection
• Mechanical properties must appropriate for
desired application
• Areas subjected to cyclic loading must have good
fatigue properties -- implant materi6als cannot heal
themselves
Metallic Biomaterials
Metals Applications
8
Applications
• Bone and Joint Replacement
• Dental Implants
• Maxillo and Cranio/facial reconstruction
• Cardiovascular devices - titanium is
regularly used for pacemaker cases and
defibrillators, as the carrier structure for
replacement heart valves, and for intra-
vascular stents.
• External Prostheses
• Surgical instruments
Other Uses
Medical Tubing
Stents
Catheters
Chemical Properties of Metals:
Most elements are metals. 88 elements to the left of the stairstep line are metals or metal like elements
Nature of Metals
• Crystalline solids composed of elemental,
positively charged ions in a cloud of electrons
Methods of Metals Processing/Manufacturing
• Forming metals
- Forging
- Rolling
- Extrusion
- Drawing
• Casting metals
- Sand casting
- Investment casting
• Powder processing of metals
• Rapid manufacturing of metals
• Welding metals
• Machining of metals
Metallic biomaterials
Early Metallic Biomaterials
Old civilizations: detailed dental work on a mummy from ancient Egypt that
archaeologists have dated to 2000 BCE. The work shows intricate gold work
around the teeth. This mummy was found with two donor teeth that had holes
drilled into them. Wires were strung through the holes and then around the
neighboring teeth
15
Metallic Biomaterials
Biometals Applications
16
Photograph taken from British Science Museum, July 2011
Metallic Biomaterials
17
Physical Properties of
Metals:
• Luster (shininess)
• Good conductors of heat and electricity
• High density (heavy for their size)
• High melting point
• Ductile (most metals can be drawn out into thin
wires)
• Malleable (most metals can be hammered into
thin sheets)
56
Metallic Biomaterials
Disadvantages
• Low biocompatibility
• Corrosion
• Too high stiffness compared to tissues (in some
orthopaedic application)
• High density (in some orthopaedic application)
• Allergic tissue reactions(release of metal ions)
• Restenosis (stents)
19
Metals
Most widely used metallic elements include:
- Iron
- Copper
- Lead
- Zinc
- Aluminum
- Tin
- Nickel
- magnesium
20
Metals
• Pure/alloy
• Alloy: a combination of elements that exhibits the
properties of a metal for improvement of:
- Strength
- Ductility
- Hardness
- Wear resistance
- Corrosion resistance
21
Orthopaedic Implant Materials
• Three main categories for orthopedic
implants
– Stainless steels
– Cobalt-chromium alloys
– Titanium alloys
23
Metals
• Plasticity depends on:
the ability to shape and contour Al and stainless steel
to match body contours
• Elasticity governs:
their safe and economical use as load-bearing
members
24
Commercial names for
Metals
• Surgical steel
• Stainless steel: large amount of chromium (>3.99%)
• Tool steel: a wide variety of steels that are capable of
attaining a high degree of hardness after heat
treatment
• Heat treated
• Spring steel: refers to a group of steels ranging in
chemical composition from medium to high-carbon
steel
25
Steel
• Any iron-based alloy material
26
Steel alloys
• Carbon steel: iron with added carbon (1% by weight)
+ manganese+ traces of sulfur & phosphorus
27
Steel alloys
• Alloy steel: carbon steel + other chemicals
28
Characteristics
• Nickel steel: improved toughness, simplified heat
treating, less distortion in quenching and corrosion
resistance
30
Steel alloys
• Stainless steel: large amount of chromium (>3.99%)
31
Stainless steel
• Radiopaque
undesirable for scoliotic patients wearing
orthosis
32
Stainless steel
• Joints
• Support uprights
• Band material
33
Aluminum
Advantages:
- high strength/weight ratio
- Corrosion resistance
- radiolucent
Solution:
Applying various hard coatings, such as anodic or oxide
finishes
Mechanical finishes: polishing, buffing, sandblasting offer
attractive cosmetic appearance for devices
35
Comparison Steel vs Aluminium
Under equal amount of stress:
- Steel strains one third as much as Al
- Al weighs approximately 1/3 as much as steel
- Al easier to work with than steel
- Al: bulky
- Al: more subject to fatigue failure
36
Titanium
• Stronger than Al and comparable strength to some steels
• Density: 60% of steel
• Titanium prosthetic components lighter in weight than steel
counterparts, require less energy expenditure
• Also more resistant to corrosion than Al and steel
• Disadvantage: more difficult to machine and fabricate in P&O
labs
more expensive! 37
Titanium
• 2.2 million pounds of Ti implanted every
year
• Hip joints, bone screws, knee joints, bone
plates, dental implants, surgical devices,
and pacemaker cases
• Due to its total resistance to attack by body
fluids, high strength and low modulus.
59
Dental Metals: Nitinol
• NIckel-TItanium-Naval Ordinance Lab
• Shape memory alloy (SMA): ability to return
to a predetermined shape when heated
Dental Metals: Nitinol
74
Metallic Biomaterials: Cardiovascular
Atherosclerosis Implants
lRisk factors:
lSmoking, diabetes,
hypertension,
hypercholesterolaemia, obesity,
age…
*American Heart Association. 2001. 2002 Heart and Stroke
Statistical Update.
Metallic Biomaterials: Cardiovascular
Implants
Complications
Potential stroke
Vulnerable plaque:
•Advanced lesions
•Thin fibrous cap
•Mainly lipid-rich plaque
•Increase in inflammatory cells
•Stresses (chronic inflammation,
emotional stress, intraplaque
hemorrhage, hemodynamic
conditions, mechanical factors)
http://health.allrefer.com/health/carotid-artery-surgery-atherosclerosis-of-internal-carotid-artery.html
Metallic Biomaterials: Cardiovascular
Implants
Complications
• Lower extremities:
– Foot
– Peripheral arterial disease
http://www.stanfordhospital.com/healthLib/atoz/cardiac/arteries.html
Metallic Biomaterials: Cardiovascular
Treatment Implants
Balloon
Stent
Revascularization: a non-
surgical procedure to reduce
an arterial blockage
Stents
Stents are metallic implantable tubular
devices used as mechanical scaffolds to
the vascular wall during revascularization
procedures of coronary or peripheral
arteries.
Before After
http://www.fda.gov/hearthealth/treatments/medicaldevices/stent.html
Metallic Biomaterials: Cardiovascular
Implants
http://www.sma.org.sg/smj/4006/articles/4006me2.html
Coronary artery bypass grafting
(CABG) or Heart ByPass
• Heart Bypass, which bypasses stenotic arteries
by grafting vessels from elsewhere in the
body, is an alternative treatment.
• coronary revascularization by CABG is
associated with an increased risk of stroke
74
Metallic Biomaterials: Cardiovascular
Implants
Bypass Vs PTCA
Angioplasty with or without
stenting Bypass Surgery
TAXUS stent
http://www.jnj.com/our_company/history/history_section_4.htm
http://www.smalltimes.com/document_display.cfm?section_id=45&document_id=740
Metallic Biomaterials: Cardiovascular
Economic facts and FDA Implants
status
78
http://en.wikipedia.org/wiki/Dental_implant
Procedure Metallic Biomaterials: Dental Implants
81
http://www.intechopen.com/books/implant-dentistry-a-rapidly-evolving-practice/factors-affecting-the-success-of-dental-implants
Metallic Biomaterials: Dental Implants
82
Metallic Biomaterials: Bone Implants
Reproduced from Corrosion of bio implants (2003).U, MUDAL, Kamachi U et al .Sadhana .Vol. 28, Parts 3 & 4, pp.
601–637
83
Knee replacement Metallic Biomaterials: Bone Implants
Knee replacement surgery as a treatment for severe knee pain and disability from rheumatoid
arthritis, osteoarthritis, or traumatic injury.
Several manufacturers make knee implants and there are more than 150 knee replacement
designs on the market today.
84
http://orthoinfo.aaos.org/topic.cfm?topic=a00221
Metallic Biomaterials: Bone Implants
Material Criteria
85
Metallic Biomaterials: Bone Implants
Hip replacement
Men and patients who weigh more than 165 lb have higher rates of failure. The
chance of a hip replacement lasting 20 years is approximately 80%.
86
Metallic Biomaterials: Bone Implants
Implant fixation:
cement and cementless
Cemented fixation relies on a stable interface
between the prosthesis and the cement and a
solid mechanical bond between the cement and
the bone. The most commonly used bone
cement is an acrylic polymer called
polymethylmethacrylate (PMMA).
88
Reference: Medical Multimedia
The steps involved in
Group
replacing a diseased hip with
(http://www.sechrest.com/mmg/)
an uncemented artificial hip
begin with making an incision
on the side of the thigh to
allow access to the hip joint.