TDM
TDM
GROUP # 02
Faria Maium Iqra
Hamna Tanveer Marium Akber
Mibsar Mushad Sadia Ijaz
What is TDM?
Therapeutic drug monitoring is the measure of the plasma
concentration level of the drug and the coordination of this serum
level with a serum therapeutic range.
OR
TDM is the clinical practice of
Drug in Drug in
measuring specific drugs at blood tissue
designated intervals
to maintain a constant
concentration the patient’s
bloodstream thereby optimizing Sample removed for drug
individual dosage regimen. Concentration
determination
CLINICAL SIGNIFICANCE
OF TDM:
•Maximizes efficacy
•Avoids Toxicity
•Identifies therapeutic failure
- Non compliance, sub therapeutic dose.
•Facilitates adjustment of dose
- New dose = Old dose x Desired Css/ Old Css
•Facilitates the therapeutic effect of drug by achieving target drug conc.
•Identify poisoning drug toxicity and drug abuse
PROCESS OF TDM
A DIAGNOSIS IS MADE
DRUG IS SELECTED
DRUG IS ADMINISTERED
•Many drug interactions, contact the pharmacy dept for the detailed
info