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Effervescent Tablets

Effervescent tablets are tablets intended to be dissolved in water before administration. They contain acid substances and carbonates that react rapidly in water to release carbon dioxide. Effervescent tablets provide benefits like fast onset of action, no need to swallow tablets, and improved palatability. They are prepared using active ingredients, acid sources like citric acid, and alkaline compounds like sodium bicarbonate. Effervescent tablets are evaluated based on parameters like disintegration time, dissolution time, and carbon dioxide content to ensure proper reaction and delivery of active ingredients.

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Ankush Bhushan
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548 views

Effervescent Tablets

Effervescent tablets are tablets intended to be dissolved in water before administration. They contain acid substances and carbonates that react rapidly in water to release carbon dioxide. Effervescent tablets provide benefits like fast onset of action, no need to swallow tablets, and improved palatability. They are prepared using active ingredients, acid sources like citric acid, and alkaline compounds like sodium bicarbonate. Effervescent tablets are evaluated based on parameters like disintegration time, dissolution time, and carbon dioxide content to ensure proper reaction and delivery of active ingredients.

Uploaded by

Ankush Bhushan
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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EFFERVESCENT TABLETS : 

Effervescent tablets


Effervescent tablets As per revised definition proposed
to US FDA, Effervescent tablet is a tablet intended to be
dissolved or dispersed in water before administration.
Effervescent tablets are uncoated tablets that generally
contain acid substances and carbonates or bicarbonates
and which react rapidly in the presence of water by
releasing carbon dioxide. They are intended to be
dissolved or dispersed in water before use.
INTRODUCTION :

INTRODUCTION Active Ingredients


1.Drugs difficult to digest or disruptive to the stomach
as calcium carbonate tablets
2.pH-sensitive drugs such as amino acids and
antibiotics
3. Drugs requiring a large dose
Effervescent delivery can be highly beneficial in the
following treatments:
• Arthritis, inflammation and pain management
• Ulcers and gastrointestinal
• Allergies
• Osteoporosis
Drugs and drug compositions used as effervescent products
 • Acetylsalicylic acid (Aspirin)
• Paracetamol (Acetaminophen)
• Ibuprofen
• Antacid preparations
• Ascorbic acid and other Vitamins
• Calcium
• Acetylcysteine, a mycolytic agent used as an antidote for
paracetamol overdosage.
• Activated charcoal preparations used in the management of
theophylline poisoning
Advantages of effervescent tablets:

Advantages Of Effervescent Tablets
1.Fast onset of action
2.No need to swallow tablets
3.Good stomach and intestinal tolerance
4.More portability
5.Improved palatability
6. Superior stability
7. More consistent response
8. Incorporation of large amounts of active ingredients
9. Accurate dosing
10. Improved therapeutic effect
Preparation of Effervescent tablets

Preparation of Effervescent tablets RAW MATERIALS


The effervescent tablet mainly consists of three
components:
• Active ingredient;
• Acid source;
• Alkaline compound, constituted by a carbonate or
bicarbonate
Acid Sources Three main acid sources are food acids
(naturally occurring), acid anhydrides and acid salts.
Food acids
1] Citric acid
2] Tartaric acid
3] Ascorbic acid
4] Fumaric acid
5] Malic acid
6] Adipic and succinic acids
7] Acetyl salicylic acid
Acid Anhydrides Citric anhydride and succinic
anhydride Glutamic acid Acid Salts
1] Sodium dihydrogen phospate (monosodium
phospate)
2] Disodium dihydrogen pyrophospate (sodium acid
pyrophospate)
3] Acid citrate salts
4] Amino acid hydrochlorides
5] Sodium acid sulphite
Carbonate Sources
1] Sodium bicarbonate
2] Sodium carbonate
3] Potassium bicarbonate and potassium carbonate
4] Sodium sesquicarbonate
5] Sodium glycine carbonate
6] l-lysine carbonate
7] Arginine carbonate
8] Amorphous calcium carbonate
9] Calcium carbonate
Formulation Ingredients :
Formulation Ingredients
1. Diluents : lactose, mannitol, sorbitol or mixtures thereof and spray-dried
lactose
2. Binders : Polyvinyl pyrolidone, Maltilol was also found to be a suitable binder
for vitamin C
3. Disintegrants : Dextrose and / or sucrose
4 .Lubricants : factors need consideration solubility and disintegration
5 .Glidants
6 .Antiadherants : polytetrafluoroethylene, polyurethane,
7 .Sweeteners : sucrose, lactose, xylitol, D-glucose, sorbitol or mannitol
8 .Flavors : orange, lemon, pineapple
9 .Colors carotenoids and chlorophyll
10. Surfactants
11 .Antifoaming Agents : dimethyl siloxane
MANUFACTURING :
MANUFACTURING Methods For Manufacturing
Environmental Conditions Wet Granulation Method
TWO-STEP GRANULATION METHOD ONE STEP
GRANULATION METHOD Using water Dry
Granulation Methods SLUGGING DIRECT
COMPRESSION Granulation By Heating TWO-STEP
PROCESS ONE- STEP PROCESS Tabletting Of
Effervescent Granules
EVALUATION :

EVALUATION Evaluation parameters for effervescent tablets.
•Disintegration Time/Effervescent Time
•Dissolution Time
•Weight Variation
•Content Uniformity Other parameters considered by various scientists
include
• Crushing Strength/Hardness
• Friability
• Water content & Moisture Uptake Studies
• Carbon dioxide content
• pH of the solution
• Organoleptic properties
The physical and chemical properties of the
effervescent tablets need special consideration during
the evaluation. Physical Properties Disintegration
Time/Effervescent Time Dissolution Study Hardness
And Friability Tablet Weight Water Content
Determination of water content Carbon dioxide
Content
Chemical Properties In-Process Quality Control
• Tablet weight
• Weight variation
• Thickness
• Crushing strength
• Disintegration
• Appearance of the tablet
• Friability
• pH of solution Stability Packaging materials Filling
Packaging Problems
Thank
You

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