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Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions

This document summarizes a journal article about meningiomas. Meningiomas are the most common primary central nervous system tumors, arising from meningothelial cells. They present with non-specific symptoms depending on location. The World Health Organization classifies meningiomas into grades I-III based on malignancy. Risk factors include ionizing radiation, obesity, and hormones. Diagnosis involves imaging like MRI and CT, as well as histological verification. Treatment is individualized and may include observation, surgical resection, radiotherapy, or rarely chemotherapy. Radiation therapy is often used for unresectable meningiomas.

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25 views

Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions

This document summarizes a journal article about meningiomas. Meningiomas are the most common primary central nervous system tumors, arising from meningothelial cells. They present with non-specific symptoms depending on location. The World Health Organization classifies meningiomas into grades I-III based on malignancy. Risk factors include ionizing radiation, obesity, and hormones. Diagnosis involves imaging like MRI and CT, as well as histological verification. Treatment is individualized and may include observation, surgical resection, radiotherapy, or rarely chemotherapy. Radiation therapy is often used for unresectable meningiomas.

Uploaded by

wibawa surya
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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JURNAL READING

Meningioma: A Review of Epidemiology, Pathology, Diagnosis,


Treatment, and Future Directions
Oleh:
Alifie Surya Wibawa
202220301011130

Pembimbing:
dr. Intan Nurswida, Sp.S

SMF NEUROLOGI
RSUD JOMBANG
FAKULTAS KEDOKTERAN
UNIVERSITAS MUHAMMADIYAH MALANG
2023
Title Meningioma: A Review of
Epidemiology, Pathology, Diagnosis,
Treatment, and Future Directions
Name of journal Biomedicines

Year 2021

Writers Christian Ogasawara, Brandon D.


Philbrick, and D. Cory Adamson
INTRODUCTION
• Meningiomas are the most common primary
central nervous system (CNS) tumors.
• They are usually benign  meningothelial
(arachnoid) cells (MECs)
• These tumors can lead to morbidity
• presenting with a variety of non-specific,
location dependent symptoms.

1
WHO CLASSIFICATION GRADING OF
MENINGIOMA
EPIDEMIOLOGY
IONIZASING OCCUPATIONAL
RADIATION

OBESITY HORMONES
RISK
FACTOR
CLINICAL
FEATURES
CLINICAL FEATURES

Headache Vertigo/dizziness

Focal cranial
Ataxia/gait change
nerve deficit
SIGN AND
SYMPTOMS
Seizure Pain/sensory change

Cognitive
Proptosis
change Asymptomatic
CLINICAL FEATURES
DIASNOGTICS Usually appear isodense relative Meningiomas can present with
to cerebral cortex but can histologic features such as
occasionally be hyperdense or pathognomonic whorls, and
slightly hypodense intranuclear cytoplasmic

Magnetic Positron
Computed
Resonance Emission Histological
Tomography
Imaging Tomography Verification
(CT)
(MRI) (PET)

Hypo- to isointense relative to imaging using SSTR ligands such


the cerebral cortex on T1- as 68Ga-DOTATOC and 68Ga
weighted sequences and iso- to DOTATATE has been used as a
hyperintense on T2-weighted diagnostic tool and to help
sequences delineate healthy tissue from
meningiomas
CLINICAL FEATURES

TREATMENT
Treatment for meningiomas is highly individualized and includes a
combination of observation, surgical resection, radiotherapy, and
rarely chemotherapy
CLINICAL FEATURES
TREATMENT
CLINICAL FEATURES
TREATMENT
CLINICAL FEATURES
TREATMENT

Radiation therapy (RT) has become a first-line treatment for unresectable


meningiomas, such as certain skull base meningiomas that have encased
neurovascular structures
THANKS

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