DR - Kima Presentation
DR - Kima Presentation
Presented by,
Dr. P.C. Lalrokima
ANTIBIOTICS???
Antibiotics kan tih chuan natna hrik (micro-
organisms) thenkhat thahna emaw than tih thut
nana natna hrik dang atanga chemical chikhat an
lak chhuah kan ti thei awm e.
Antibiotics te hi an hnathawh dan a zirin chi hrang
hrangah an in then hrang veleh a, chungte chu:
Pg 49
Brand name hman langsar zual thenkhat te:
Dicrysticin, FPP, Bistrepen, Pendistrin-SH, Munamycin, Dicrysticin LD,
Inclox, Ciclox, Vetclox, AC Vet, AC Vet forte, Nepoclox,Bacipen, Hipenox,
Colampi, Catcillin, Solampi, Intamox D, Moxel D, Intamox Z,
Amoxirum,etc..
CEPHALOSPORINS (Cell Wall Inhibitor)
1st generation: Moderate spectrum niin heng E.coli,
Klebsiella pneumoniae & Proteus mirabilis natna hrik
hovina an thlen ho natna hrik thah nan an hman theih a,
amaherawhchu Bacteriodes fragilis, Enterococci,
methicillin-resistant staphylococci, Pseudomonas,
Acinetobacter, Enterobacter, indole-positive Proteus or
Serratia.
e.g: Cephalexin,ceftezole,cefazolin,cefatrizine,etc.
2nd generation: Gram –ve bacteria natna hrik thahnan
an tha em em a,tin gram +ve cocci natna hrik ho thah nan
pawn an hman tlak tho bawk. B-lactamase enzyme kan tih
natna hrik tena B-lactam antibiotics ho an lo do let
theihna enzyme chikhat lakah pawh resistant an nei tha
hle.
3rd generation:
Broad spectrum niin CNS lut tlang(penetrate) thei an
ni a, heng natna hrik Pneumococci, meningococci,
H.influenza, E.coli, Klebsiella leh penicillin resistant
N.gonorrhoeae te thahnan hian an tha in,meningitis
gram-ve natna hrik in a thlen bikah phei chuan drug of
choice an ti hial a ni.
Side effects:
Allergy, kal thalo etc.
Cephalosrorin group of drugs Dose leh Route te:
Pg 57
Brand name hman langsar zual thenkhat te:
Vetaceph, Intacef, Macef, Moxef, X-ceft, TT-ceft,
Xonecef, Xonexef, Exact, Ceft-one, Zydaceft, Intacef
Tazo, Britax, Cefatox, Vetaxim,Cefavet, M-ceft,Cefatin,
Cephatin Sulbactam,Lixen bolus,Ladexin,Malexin,
etc.
Tetracycline (Protein synthesis inhibitor)
An hnathawh dan tlangpui:
1.Bacterial(natna hrikte) cell wall ah passive emaw active transport
hmangin an lut .
2. Interaction with bacterial ribosome
Cell wall an kal tlang hnu chuan 30S ribosome ah va belhbawm in m-
RNA complex-a acceptor A site a aminoacyl –tRNA va inbelhbawm tur chu
tibuai tlatin,natna hrik a protein synthesis lo awm tur chu a dang ta tlat thin
a ni.
Natna hrik inthlahpung chak tak that nan an tha in pH6-6.5 ah hna an
thawk chak zual thin.
Broad spectrum an ni a, anaerobic leh aerobic G-ve&
G+ve te, mycoplasma, rickettsia, chlamydia leh protozoa
thenkhat thah nan an hman theih a, amaherawhchu fungi
leh virus natna hrik thah nan erawh chuan an hman tlak
loh a ni.
Side Effects:
Pum nuamlo, ruh leh ha ah ngawng a nei thei, thin
lamah hasatna te, kal thalo te a thlen thei.
Contraindication:
Oral route in Sakawr, Ruminants ah pekloh tur,
Rai lai ah leh ran no kar 4 hnuai lamah pek loh tur.
Tetracycline group of drugs dose leh route te:
Drugs Animal Doses Route Interval
Oxytetracycline Dogs & Cats 5-10 mg/kg SC or IM 1-2 times
Cattle/Sheep/ 20 mg/kg PO 3 times
Goats/Pigs 5-10mg/kg IM/Slow IV Once
Horses 20 mg/kg IM (depot) Repeat after 2-4 days
Poultry 5 mg/kg Slow IV 1-2 times
10-25mg/kg 100 litres drinking water ----------
Enteric infection:
Dogs & other spp 15mg/kg PO Once daily
Systemic infection:
Streptomyci Dogs 5-10mg/kg IM -do-
n Cattle, sheep, goat & 10mg/kg IM -do-
horses
Eneteric: as
Framycetin/ neomycin 5mg/kg Im 2 times a day
Neomycin B Acute mastitis
Broad spectrum an niiin heng natna hrik gram+ve organisms te, gram-
ve organisms te, aerobic leh anaerobic organisms te, Rickettsiae,
Psittacosis te, nocardia te, chlamydia leh mycoplasma ho vin a an thlen
natna enkawlnan te hian an hman theih thin a ni.
Side effects:
Hypersensitive reaction ui leh zawhte ah, Bone marrow depression(Host mitochondrial
protein synthesis inhibit vangin), Aplastic anaemia,Hypoplastic anaemia, Agranulocytosis,
thrombocytopenia te a thlen thei. Tin, pumpui lamah harsatna thlen
theiin,luhai,luakchhuak,kawthalo a siam thei bawk. Lung lamah pawh harsatna a thlen thei thin
bawk.
Contraindication:
Zawhte ah hman loh hram a tha,achhanchu Glucoronide conjugation an tlakchham a vangin
an taksa in a paihchhuak tha thei thin lo.
Ran no ah emaw pianghlimah hman loh a him,a chhan chu ran nopang lutukah chuan thin ah
glucoronyl transferase in duhthusamin hna a la thawk ve thei lo va,tin kal in duh angin taksa
atangin a paih chhuak thei thin lo bawk avangin.
P.B: Macrolide antibiotics te nen hman pawlh loh tur an ni (an hnathawh na,bacterial ribosome a
an va belhbawmna site a in ang 50S ve ve an nih avangin), B-lactam antibiotics te nen pawn
hman pawlh loh tur. Tin, Ruminants ho vah Oral route in pek loh tur (a chhanchu ruminal micro
flora ten awlsam takin p-nitro reduction an lo thlen thin a ni)
Chloramphenicol group of drugs Dose leh route te:
Oral route:
Chloramphenicol palmitate:
Calves leh Foal ah 0.50g BID or TID
Piglet leh lambs ah 0.25g BID or TID
Dogs165mg/kg daily in 3 divided doses
Cats0.25g OD or BID
Intramuscular route:
Chloramphenicol sodium succinate:
Large animals2-4mg/kg
Small animals4-10mg/kg
Intravenous route:
Chloramphenicol sodium succinate: 40% solution
Fluoroquinolones
Hemi group a antibiotics ho hi chuan Supercoiling DNA
kan tih mai natna hrikin a neih te chu DNA gyrase
hmangin an tidanglama,tichuan awlsam takin natna hrik
te chu a tichhe ta thin ani.
Fluoroquinolones group of drugs hman theih na
tlangpuite:
Spectrum of Fluoroquinolone Activity
Pathogen
Gram- Gram- Anaerobic* Pseudo- Atypical† STD
positive negative monas species organ-
isms‡
Drug
Ofloxacin + +++ 0 ++ +++ +++
Ciprofloxacin + ++++ 0 ++++ ++§ ++§
Levofloxacin ++" +++ + +++ +++ +++
Sparfloxacin ++" +++ + 0 +++ +++
Gatifloxacin ++" +++ + ++ +++ +++
Moxifloxacin ++" +++ ++ ++ +++ +++
Trovafloxacin ++" +++ +++ ++ +++ +++
* Only moxifloxacin and trovafloxacin produce reliable anaerobic activity.
† Includes Legionella pneumophila, Mycoplasma pneumoniae and Chlamydia pneumoniae.
‡
Includes Neisseria gonorrhea, Mycoplasma hominis, Chlamydia trachomatis, and Ureaplasma urealyticum.
"
Activity against streptococci is enhanced; may be active against some isolates of MRSA and enterococci.
Side effects/Main toxicity:
Pumlam harsatna- luhai luakchhuak, pumna, kawthalo
CNS pawh effect tel theiin,luna,luhai leh muthilh that
theih lohna a thlen thei.
Arthropathy- Ran no leh thanglaiah ruhchuktuah ah
erosion thlenin ruhchuktuah na a thlen thei a, heavy
breeds ho leh intlansiakna atana hman sakawrah te phei
chuan hman loh tur a ni.
Kal lam thalo te,Cataract te a thlen thei
Phototoxicity/Dermal toxicity a thlen thei(a bikin
lomefloxacin leh sparfloxacin a hlauhawm zual)
Lung thalo leh thin lamah harsatna thlen thei
Mutagenicity
Embryotoxicity
Brand name hman langsar zual thenkhat te:
Cflox power, Cflox-Tz, Ciprovet-Tz, Cflox U, Curacin Tz ,Marbomet tablet,
Curacin,etc.
Erythromycin- Gram positive leh spirochetes natna hrik thahnan a hman theih a,
mahse gram negative bacteria natna hrik tan erawh a hman tlak loh.
Azithromycin- Gram positive bacteria natna hrik thah nan a hmantheih tho a,
mahse heng natna hrik H. influenzae leh H. legionella thahnan hian a tha in
Toxoplasma gondii natna hrik thahnan phei chuan duhthusam a ni.
Clindamycin:
Dogs & Cats:
5-10 mg/kg PO b.i.d
10 mg/kg IM b.i.d
SULFONAMIDES
Pteridine + PABA
A hnathawh dan tlangpuite
Dihydropteroate
SULFONAMIDES
Dihydropteroic acid
Synthase
Glutamic acid
Dihydrofolic Acid
TRIMETHOPRIM
Dihydrofolate
Tetrahydrofolic Acid
Reductase
Tetrahydrofolate
Purines Thymidine Methionine,
Reductase Glycine
Intermediate Acting
Sulphadimidine Cattle & Sheep 200mg/kg SC or IV (initial dose) follwd by 100mg/kg once daily
Pigs 20-50mg/kg IV or PO once daily
Sulphamethoxazole Dogs & Cats 100mg/kg PO (loading) follwd by 50mg/kg PO 2times daily
Long Acting
Gut Acting
ANTIHISTAMINES