Revised Slides For PMTCT Refresher
Revised Slides For PMTCT Refresher
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Presentation Outline
• MTCT of HIV
• Risk of MTCT of HIV without intervention
• ANC
• HTS
• Syphilis
• HEI follow Up
• Triple elimination
• Different formats
• Indicators
• Five year eMTCT strategy
• PIP
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MTCT of HIV
• Mother-to-Child transmission of HIV (MTCT) is the transmission of HIV
from an infected mother to her baby. It can occur during:
Pregnancy
Labor and childbirth
Breastfeeding
• Implementing the four-pronged approaches can reduce the risk of
transmission of HIV to less than 5% in breast-feeding infants, and to less
than 2% in non-breast-feeding populations.
• Promotion of safer sexual practice among sero-discordant couples;
• provision of ART for HIV positive partners and Pre-Exposure Prevention
(PrEP) for negative partners
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Risk of MTCT of HIV without intervention
Timing Transmission rate
without intervention
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ANC
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HTS
• Partner test
• HIV self test
• Sero-discordant (PrEp)
Care and treatment
• First line Choice- TDF/3TC/DTG Alternative TDF/3TC/EFV
• ART should be rapidly, preferably same day, (within an hour for
laboring mother).
• cervical cancer screening .Post-partum woman can be screened for
cervical cancer 3 months after she gave birth.
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HIV Exposed infants
• Daily dose of INH (300mg) for 6months (6H) For screen negative
• Start ART in all TB patients living with HIV as soon as possible
within 2 weeks following initiation of anti-TB treatment.
• In case of TB-HIV confection, the dose of DTG should be 50mg BID.
• To minimize the challenges that are associated to sputum based
diagnostic tests, urine based rapid TB diagnostic tests are
recommended to detect TB in PLHIV with Advanced HIV Disease.
(Alere lipoarabinomannan (LAM) assay)
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Syphilis
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Four Prongs
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Triple Elimination Strategy
• Triple elimination refers to elimination of MTCT of HIV, syphilis and Hepatitis at
national, regional, district and community levels.
• Similarity of the control interventions necessary to prevent the transmission of both
infections in pregnancy makes it feasible to establish an integrated approach
• Elimination is defined as reduction to zero of the incidence of disease or infection in a
defined geographical area.
• Considering the challenges in our health care system, the goal for EMTCT initiatives is to
reduce MTCT to a very low level, so that it is no longer a public health problem (<50 per
100,000 live births).
• Alternatively, elimination of MTCT of HIV is defined as:
transmission rate of <2% for non-breastfeeding and
<5% for breastfeeding infants (WHO, 2007 b, WHO 2014).
Goal: eliminate new pediatrics HIV infection due to MTCT and congenital syphilis by
2020 and keep their mothers alive.
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HBsAg + HBsAg –
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Viral Load Result Categories
Viral suppression:
A viral load that is undetectable, equal to or less than 50 copies/ml.
Low-level viraemia
-one or more viral load results that are detectable (more than 50 copies/ml) but equal to
or less than 1000 copies/ml.
Virological failure:
-Viral load above 1000 copies/ml based on two consecutive viral load measurements in 3
months, apart with enhanced adherence support following the first viral load test
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Treatment monitoring algorithm
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DSD Models
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MCH _DSD Model
• Mothers living with HIV and their infants are important target
population for differentiated service model (DSD).
• There are various models of care used to support MCH/HIV services.
• Some of the DSD models in Ethiopia includes
family planning service integration to HIV care,
Point of care (POC) EID testing for HEIs and VL testing for
mothers
provision of 3 month ARV dispensing for HIV positive
pregnant and breast feeding women during COVID 19
pandemic
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PMTCT cards, forms, registers
• Integrated Antenatal, Labor, Delivery, Newborn, Postnatal care chart
• HIV exposed infant follow up card
• ART Intake form
• HIV/ART chronic care follow up form
• Transfer out form
• PMTCT Dashboard
• PMTCT facility performance indicators follow up form
• Continuous quality improvement tool (CQI)
• ANC Register
• L&D Register
• PrEP Register
• PMTCT Register for Health Centers and Hospitals (mother baby pair cohort register)
• Postnatal Register
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PMTCT cards, forms, registers
• Family Planning Register
• DNA PCR specimen tracking logbook
• PMTCT appointment & LTFU Tracking logbook
• Index test testing (ICT line listing register)
• High viral load register
• Retest for verification register
• CD4 request forms
• DNA PCR request forms
• Viral load request form
• Monthly HMIS reporting forms
• PMTCT Cohort reporting form
• PMTCT SOP
• PMTCT Cohort wall chart
• PMTCT job aid
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PMTCT Indicators
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PMTCT Indicators---
4.Percentage of HIV infected women using a modern family
planning method.
Number of HIV infected women aged 15-49 reported the use of
any method of modern family planning
5. Percentage of partners of pregnant, laboring and lactating
women tested for HIV during the reporting month.
Number of partners of pregnant, laboring and lactating women
tested for HIV whose test result is HIV negative
Number of partners of pregnant, laboring and lactating women
tested for HIV whose test result is HIV positive
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PMTCT Indicators---
6. Percentage of pregnant/breast feeding women who received
routine viral load testing
7.Percentage of HIV positive pregnant & BF women with a
suppressed viral load (<1000 copies/ml)???
8.No/% of pregnant women attending antenatal care tested for
HBV
9. Number of pregnant women who were received prophylaxis
for HBV
10. Number % of pregnant women tested for syphilis
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PMTCT Indicators---
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PMTCT Indicators---
18. Percentage of infants born to HIV infected women receiving a virological test for
HIV within 12 months of birth
Number of HIV exposed infants who received an HIV DNA/PCR test within 2months of
birth, during the reporting period
Number of HIV exposed infants receiving HIV DNA/PCR test within 2months of birth
whose test result is HIV negative
Number of HIV exposed infants receiving HIVDNA /PCR test within 2months of birth
whose test result is HIV positive
Number of HIV exposed infants who received an HIV DNA/PCR test between 2to12
months, during the reporting period
Number of HIV exposed infants receiving HIV DNA/PCR test within 2to12months of
birth whose test result is HIV Negative
Number of HIV exposed infants receiving HIV DNA/PCR test within 2to12months of
birth whose test result is HIV positive
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PMTCT Indicators---
19. Percentage of Infants born to HIV-infected women started co-
trimoxazole prophylaxis within two months of birth
20. Percentage of infants born to HIV-infected women receiving
antiretroviral (ARV) prophylaxis for prevention of mother-to-child
transmission.
21. Percentage of HIV exposed infants receiving HIV
confirmatory(antibody) test by18months
• Number of HIV exposed infants receiving HIV
confirmatory(antibody)by18months-whose test result is Negative
• Number of HIV exposed infants receiving HIV confirmatory(antibody)
by18months-whose test result is Positive
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National Strategic Plan for Triple Elimination of Mother-to-Child
Transmission of HIV, Syphilis, and Hepatitis B Virus 2021-2025
OHB
Dec, 2022
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Background
HIV
• Nationally, there were an estimated 19,110 HIV
positive pregnant women in 2019
• Although the prevalence of HIV showed a
declining ,still higher among the pregnant
women
• MTCT of HIV is also high (14.96%)
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Cont’d
Syphilis
• About 80% of cases of syphilis in pregnant women can result in adverse outcomes of pregnancy
• The prevalence of syphilis ranged from 0.6% to 5.1% in studies in Ethiopia
HBV
• The prevalence of HBV among pregnant women ranges from a minimum of 2.3% in southern
Ethiopia to a maximum of 7.9% in Gambella Hospital
• The pooled prevalence of HBV infection among pregnant women was 4.8%
• High prevalence of HBV infection and syphilis among pregnant women which needs universal
screening
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Rationale for integration of HIV, syphilis and HBV as triple
framework initiative
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Cont..
• The Government of Ethiopia committed to achieve the elimination of MTCT of
HIV, syphilis and path to elimination of HBV by 2025, based on
• The experience of the earlier years (1st & 2nd EMTCT strategy)
• Available documented scientific evidence
• The current global move
• The integration of the triple elimination is a synergy to improve a broad range of
MCH services and outcomes
• Ethiopia would like to achieve and in line with the sustainable development goal (SDG)
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Situational Analysis
Targets for process and impact indicators, dual EMTCT strategy
SN Primary Indicators Baseline Target Achievement Data Remarks
in 2016 for of 2019/20 source
2019/20
1 HIV test during 85 95 85 HMIS Not
pregnancy, L & D and PNC DHIS2 achieved
(%)
2 ART for PMTCT (linked 57 95 91 HMIS Not
and Option B+) converge DHIS2 achieved
among HIV +Ve pregnant,
L & D and lactating
women (%)
3 ARV Prophylaxis among 41 95 61 HMIS Not
HIV exposed infants (%) DHIS2 achieved
4 Early Infant Diagnosis 25 95 67 HMIS Not
(EID) virologic test (at 2 DHIS2 achieved
months) (%)
5 National rate of MTCT of 18.1 <5 14.96 HMIS Not
HIV (% final) EPHI achieved
projection
6 Syphilis testing and 40.5 95 66 HMIS Not
treatment during DHIS2 achieved
pregnancy, L & D and PNC
(%)
7 Rate of congenital syphilis NA <50 Data not
(per 100,000 live births) available
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Target for process and impact indicators OHB, HMIS (2016-
2020)
Sno. Indicators Baseline in Target for Achieveme Remark
2016 2020 nt 2020
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Strategic frame work
Vision
Goal
• To achieve elimination of MTCT of HIV and syphilis, and on the path to
elimination of MTCT of HBV by 2025
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Process and impact indicators and targets
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Target for process and impact indicators OHB, 2021-2025
Sno Indicators Baseline in 2020 Target for 2025
1 1st ANC visit 98% 100%
2 HIV test at ANC, L&D and PNC >95% 95%
3 ART (Option B+) 77% 95%
4 Syphilis test at ANC 1st Visit 78% 95%
5 Reactive syphilis treatment 77% 95%
6 Hepatitis B test at 1st ANC Visit 57% 95%
7 Hepatitis B reactive prophylaxis/treatment 0 95%
8 HEI prophylaxis 68% 95
9 DNA/PCR 52% 95
10 Birth dose HBV for HEI >50%
11 Third dose of HBV for HEI >90%
12 Transmission rate 14.56% <5%
13 Case rate of congenital syphilis per 1000 live births <50
14 HBs Ag prevalence among under five children
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<1% 39
Strategic objectives
1. Enhancing the primary prevention among adolescents, women, and men;
4. Enhancing the test and treatment uptake in the maternal and neonatal
continuum of care; and
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Strategic direction
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Strategic direction….
1. Enhancing the activities towards EMTCT of HIV, syphilis, and
HBV during the continuum of preconception to neonatal care
Strategy:
1. Preconception care using available reproductive health service platforms to
enhance primary HIV, syphilis, and HBV prevention
2. Providing FP services to women in reproductive age groups to prevent
unintended pregnancy and HIV, syphilis, and HBV
3. Quality of ANC and skilled delivery and accelerate the EMTCT of HIV, syphilis,
and HBV
4. Improving screening and treatment of HIV, syphilis, and/or HBV infections
during pregnancy
5. Increasing the treatment uptake for HIV, syphilis, and/or HBV infections
6. Increasing the testing, prophylaxis, and treatment uptake of infants exposed to
HIV, syphilis, and/or HBV
7. Integrating HIV, syphilis, and HBV point-of-care testing in other RH service
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Strategic direction ……
2. Strengthening community mobilization, engagement schemes
Strategy:
1. Enhancing the community mobilization to increase the national coverage of the pregnant
2. Increasing public awareness about the benefit of early diagnosis of HIV, syphilis, and HBV
3. Promoting male/partner involvement in the maternal and neonatal continuum of care
Strategy:
1. Improving the health facilities capacity to achieve the EMTCT of HIV, syphilis, and HBV
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Strategic direction……
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Cont’d
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Roles and responsibilities stakeholders in the
implementation of strategic plan
Parliamentarian and political leaders
The Ministry of Health (MOH) with the HAPCO
PMTCT TWG, RHBs,, HFs, HEP
Zone and wored health offices
Faith Based and Civil Society Organizations, including mothers living
with HIVDevelopment Partners, donors & implementing partners
Media and communication
Universities and colleges
Private Sector and the business community
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Dash board for 11months,2015
SNo Indicators present (%) Score
1 HIV test for mothers 100
2 ART uptake 66
3 Dual prophylaxis 42
4 DBS 56
5 DBS <2months 67
6 CPT 43
7 Syphilis test 80
8 Syphilis positive Rx. 100
9 Hepatitis B test 97
10 Hepatitis B test prophylaxis/RX 0.1
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Performance improvement plan
Program Gap identified Action items Responsible
Low engagement of leadership at lower level Provide awareness creation/work shop on PMTCT
PMTCT services for leaders Team/C&T/OHB
five year strategic plan of eMTCT is not lounched Launch eMTCT five year plan at regional
level OHB
OHB/ZHD/THO/WHO
low commitment at zone/town/woreda and Facility level Ensure accountability at all level
No assign focal person at all level assign focal person at all level ZHD/THO/WHO
Leadership and
management Avail PMTCT service 8hrs a day by Facility Mgt.
Intrubtion of the PMTCT service during night off assigning responsible person.
Establish PMTCT/Pediatric TWG at OHB
No functional TWG at regional level region level
Trained staff turnover and shortage Trained PMTCT Provide basic and gap filling
provider trainings/refresher PMTCT Team/C&T
Poor Sample and result tracking system Ensure referred sample and truck result timely Lab/PMTCT
Referring/Testing /Post
Long TAT Monitor and follow EID TAT at all level office
Frequent DBS kit and Cartridge stock out in some
HF Timely report RRF and communicate EPSS EPSS/RHB
EID commodities are not timely requested by RRF Ensure timely request of RRF HFs store/RHB/RRL
EID supply
Management
Poor supply management(IFRR,Bincard.etc) at
HFs level Ensure regular IFRR and Bin card updating HFs store/Lab/RRL