Anxiety and OCD Disorders
Anxiety and OCD Disorders
• Introduction
• Anxiety disorders
• Obsessive compulsive disorders
Introduction
• Anxiety
A diffuse, unpleasant, vague sense of apprehension, often
accompanied by autonomic symptoms such as headache, perspiration,
palpitations, tightness in the chest, mild stomach discomfort, and
restlessness, indicated by an inability to sit or stand still for long
Anxiety is a response to a threat that is unknown, internal,
vague, or conflictual
Emotional response to anticipated future threat
• Fear :
Fear is a response to a known, external, definite, present or
nonconflictual threat
Epidemiology
• Anxiety disorders have annual and lifetime prevalence of 18%
and 28% respectively.
• Demographic factors
Sex
Early age of onset
Childhood adverse events
Comorbid with unipolar depression
• Significant impairment in the life of patients
Etiology
• Psychoanalytic theory
Indicator of unconscious threat/affect/ that is going to be
conscious
Leads to mobilization of defense mechanisms which limit
such dangers thoughts access to consciousness
Symptoms are compromise formation of the above factors
• Cognitive and behavioral theories
Anxiety sensitivity
Overestimation of the threat and its consequence
Underestimation of ones capacity to deal with it
Specific cognitive distortions
Classical conditioning
• Biological factors
Noradrenergic system
Excessive and hyperactive secretion of NE
Dysfunctional presynaptic alpha2 receptors
Hypothalamic pituitary adrenal axis (HPA)
Increased level of cortisol and CRH
Chronically hyperactive
Mediated by childhood trauma
Fear processing circuits
Physical Symptoms of Anxiety?
• Physical
Pounding heart Tremors & twitches
Sweating Muscle tension
Stomach upset Headaches
Dizziness Fatigue
Frequent Insomnia
urination/diarrhea
Shortness of breath
Affective Symptoms of Anxiety
• Emotional
Apprehension or dread
Trouble concentrating
Tense & jumpy
Anticipating the worst
Irritability
Restlessness
Vigilance
‘blank mind’
Behavioral Symptoms of Anxiety
Characterized by avoidances
Noncompliance with medical procedure
Panic disorder
• Panic disorder is a common, distressing, and often disabling
condition in which patients experience recurrent unexpected
panic attacks
• Panic attacks
Are periods of intense fear, apprehension, or discomfort that develop
suddenly and tend to reach a peak of intensity within 10 minutes of the
initiation of symptoms
Experienced as unprovoked ,unexplained and out of the blue
• DSM V criteria require that at least 4 of 13 symptoms be present
to diagnose a panic attack
Panic Attack Symptoms
• Cardiac: palpitations, tachycardia, chest pain or discomfort
• Pulmonary: shortness of breath, a feeling of choking
• GI: nausea or abdominal distress
• Neurological: trembling and shaking, dizziness,
lightheadedness or faintness, paresthesias
• Psychological : depersonalization , derealization , fear of
dying and losing control
Cont.
• Anticipation and worry that there might be additional panic
attack
• Change in behavior so that to avoid the possibility of
additional panic attacks
Treatment
• Cognitive behavioral psychotherapy
• Psychodynamic therapy
• SSRIS
• Benzodiazepines
Social anxiety disorder
• Characterized by excessive anxiety in social situations where
one is exposed to possible scrutiny
• Fear of embarrassing one self and humiliating performance or
interpersonal interactions
• Avoidance these social situations
• Circumscribed or generalized
Cont.
• Etiological factors
Onset during early adolescence
Behavioral inhibition
Modeling of parental social anxiety
Social “traumatic“ experiences
Treatment
• Cognitive behavioral therapy
• SSRIS
I-Generalized Anxiety
Disorder
Generalized Anxiety Disorder
• Paradigmatic OCRD
• Constituted by either obsessive or compulsive
symptoms
• Obsession
Intrusive and unwanted repetitive thoughts, urges, or
impulses that often lead to a marked increase in anxiety or
distress
• Compulsions
Repeated behaviors or mental acts that are done in
response to obsessions, or in a rigid rule-bound way
Aimed to reduce obsession related anxiety and distress
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Cont.
• Neuropsychiatric disorder
Monozygotic twins concordance 80- 87%
Abnormalities in cortico-striatal-thalamic-cortical (CSTC) circuitry
Cognitive inflexibility and excessive habit formation
Motor impulsivity
Disgust sensitive
Represents impaired control of automated, habitual behaviors
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• Typical Symptoms
Contamination
Pathologic doubt /checking/
Intrusive/forbidden / thoughts
Symmetry/ordering
A lot of time spent on because of these
Impact also significant to Family around patient
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Treatment
• Psychoeducation
• SSRIS
• Clomipramine
• CBT (Exposure and response prevention therapy)
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