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LECTURE SEVEN
MATERIAL SAFETY DATA SHEET (MSDS)
Provides more detailed information about a chemical, including ◦ Composition, information on ingredients (Section 2) ◦ Hazards identification (Section 3) ◦ First aid measures (Section 4) ◦ Accidental Release measures (Section 6) ◦ Handling and Storage (Section 7) ◦ Exposure controls, personal protection (Section 8) ◦ Stability and reactivity (Section 10) ◦ Toxicological information (Section 11) Hazards Identification ◦ Inhalation: Respiratory tract (lungs) through inhalation ◦ Ingestion: Digestive tract through eating or smoking with contaminated hands or in contaminated work areas ◦ Absorption through the skin or eyes: Dermatitis or damage to the liver, kidney, or other organ systems ◦ Injection: Percutaneous injection of a toxic substance through the skin
Specific possible health hazards:
◦ Acute poisoning (rapid assimilation of substance, i.e., carbon monoxide)
◦ Chronic poisoning (prolonged exposure, i.e., lead poisoning) ◦ Cumulative poisons (numerous chronic exposures, i.e., heavy metals) ◦ Substances in combination (synergistic effect, i.e., exposure to alcohol and chlorinated solvents) Potential Health Effects ◦ Eye irritation ◦ Nausea ◦ Dizziness ◦ Skin rashes ◦ Headache ◦ Existing medical conditions possibly aggravated by exposure
◦ Emergency/first-aid procedures to follow
◦ Accidental Release Measures What to do if substance spills and leaks How to correctly dispose of substance Equipment/procedures for cleaning up spills and leaks Handling and Storage ◦ How to handle and store substance safely ◦ Any other precautions (i.e., grounding containers during transfer of flammables) ◦ Exposure Controls, Personal Protection Respirator Gloves Eye protection Protective clothing Ventilation ◦ Handling chemicals with care ◦ Dispose of chemicals, broken glass, and other waste in approved containers ◦ Clean up broken glass and spills immediately ◦ Keep the lab clean and neat ◦ Store incompatible chemicals in separate storage areas ◦ Labs have established separate storage areas for Flammable and combustible organic liquids and solvents Acids Dry poisons, salts, and oxidizers Bases
◦ Chemicals are stored in
Chemical storage cabinets Flammable storage refrigerators Chemical storage refrigerators/freezers On shelves with retaining barriers ◦ Storage fundamentals ◦ Identify incompatible chemicals – check the Material Safety Data Sheet ◦ Isolate and separate incompatible materials ◦ Isolate by storing in another area or room ◦ Degree of isolation depends on quantities, chemical properties and packaging ◦ Separate by storing in same area or room, but apart from each other
◦ Storage must not limit the use of exits, stairways, or areas normally used for the safe passage of people.
◦ Storage must be in:
◦ closed metal containers inside a storage cabinet, or ◦ safety cans, or ◦ an inside storage room ◦ Use protective clothing ◦ Eye Protection Safety glasses – flying particles, chemical splashes, dust Splash goggles – corrosive liquids, solvents, powders Face Shields – high pressure systems ◦ Respiratory Protection ◦ Skin and Body Protection Gloves – see the MSDS Aprons and lab coats – strong acids and bases Shoes – always worn in lab, closed toe and closed heel ◦ Hearing Protection ◦ Do not:- ◦ Use damaged glassware ◦ Store chemicals near heat, sunlight, or other substances with which they might react ◦ Store materials on floors or other places where people could trip over them ◦ Leave equipment unattended when its operating (unless it is designed to do so or you have an SOP) ◦ Put custodians and fellow workers in danger
◦ If exposed to hazardous materials:
◦ Eyes: Flush with water for 15 minutes ◦ Ingestion: Follow label and MSDS instructions ◦ Skin Contact: Stand under emergency shower and remove contaminated clothing immediately ◦ Inhalation: Get to fresh air and get prompt medical attention ◦ Since the laboratory is prone to accidents, it is important for a lab user to be keen and follow the following simple rules:- • Avoid working alone in the lab • Know where emergency phone numbers are posted • Review MSDS • Know where to go and what to do in an emergency • Know the location of the closest safety showers, eyewashes, and fire extinguishers • Always follow the guidance of the laboratory technician