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Mol - Basic.Inh. Feb 13, 2024

cell signaling

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14 views47 pages

Mol - Basic.Inh. Feb 13, 2024

cell signaling

Uploaded by

Awais Gul
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Course: MBG:701 Molecular Basis o f

Inheritance

Cell
Mitosis and Meiosis
Division
Kiran Konain

Visiting Lecturer IBMS | Doctoral Researcher | Research Assistant


Team Member: Cancer Cell Culture & Precision Oncomedicine Lab, Oral Biology Lab

Institute of Basic Medical Sciences


Khyber Medical University
Peshawar 25100, Pakistan
February 13th, 2024
What is Cell?
Why Do Cells Divide?

For growth, repair, and reproduction


Mitosis
•Organisms grow by the addition
of cells
•In multicellular organism some of
these cells perform functions
different from other cells.
•The process of a cell becoming
different is differentiation.
•Under normal conditions once
an animal cell becomes
specialized it can no longer
form an entire organism,
however plant cells are
totipotent and any cell can
form an entire plant.
Cell Division vs. Nuclear Division

• Cytokinesis: The actual division of the cell


into two new cells.

• Mitosis: The division of the nucleus of the


cell into two new nuclei.

• Note: Sometimes cells go through mitosis


without going through cytokinesis.
Describe a cell that did this.
Terminology
•Chromatin - thin fibrous form
of DNA and proteins
•Sister chromatids- identical
structures that result from
chromosome replication,
formed during S phase
Anatomy of a Chromosome
p -arm
• Centromere - point
where sister
chromatids are joined
together
centromere • P=short arm; upward
• Q=long arm;
q-arm downward
• Telomere-tips of
chromosome

chromatids telomere
How Do Cells Divide?

•Cell cycle - sequence of phases


in the life cycle of the cell
Getting ready to split
•Cell cycle has two parts:
–growth and preparation
(interphase)
–cell division
•mitosis (nuclear
division)
•cytokinesis (cytoplasm
division)
Interphase
•Occurs between divisions
•Longest part of cycle
•3 stages
Interphase

•G1 or Gap 1
–The cell just finished
dividing so in Gap 1 the
cell is recovering from
mitosis
Interphase

•S or Synthesis stage
–DNA replicates
Interphase
•G 2 or Gap 2
–This is preparation
for mitosis
–Organelles are
replicated.
–More growth
occurs.
MITOSIS
Mitosis begins after G 2 and ends
before G 1
Prophase
•Chromosome
condense
•Microtubles
form
•The nuclear
envelope breaks
down
Metaphase

•Chromosomes are
pulled to center
of cell
•Line up along
“metaphase plate”
Anaphase
•Centromeres divide
•Spindle fibers pull
one set of
chromosomes to each
pole
•Precise alignment is
critical to division
Telophas
e
• Nuclear envelope form
around chromosomes
• Chromosomes uncoil
• Cytokinesis
– animals - pinching of
plasma membrane
– plants- elongates and the
cell plate forms( future
cellwall and cell
membrane)
Meiosis
What is Meiosis?
A division of the nucleus that
reduces chromosome number by
half.
•Important in sexual reproduction
•Involves combining the genetic
information of one parent with that of
the the other parent to produce a
genetically distinct individual
Terminology
• Diploid - two sets of
chromosomes (2n), in humans 23
pairs or 46 total
• Haploid - one set of
chromosomes (n) - gametes or sex
cells, in humans 23 chromosomes
Chromosome Pairing
•Homologous pair
–each chromosome in pair are
identical to the other ( carry genes
for same trait)
–only one pair differs - sex
chromosomes X or Y
Phases of Meiosis
•A diploid cell replicates its
chromosomes
•Two stages of meiosis
–Meiosis I and Meiosis II
–Only 1 replication
–Synapsis - pairing of homologous
chromosomes forming a tetrad.
–Crossing over - chromatids of
tetrad exchange parts.
Meiosis I
Prophase I
• Chromosomes condense
• Homologous chromosomes pair w/
each other
• Each pair contains four sister
chromatids - tetrad
Prophase I
Metaphase I
•Tetrads or
homologous
chromosome
s move to
center of cell
Anaphase I
•Homologous
chromosome
s pulled to
opposite
poles
Telophase I
•Daughter
nuclei formed
•These are
haploid (1n)
Meiosis II
•Daughter cells undergo a
second division; much like
mitosis
•NO ADDITIONAL REPLICATION
OCCURS
Prophase II
•Spindle fibers
form again
Metaphase II
• Sister
chromatids
move to the
center
Anaphase II
•Centromere
s split
•Individual
chromosome
s are pulled
to poles
Telophase II & Cytokinesis
•Four haploid
daughter cells
results from
one original
diploid cell
Review Mitosis & Meiosis
•Both are forms of nuclear division
•Both involve replication
•Both involve disappearance of the
nucleus, and nucleolus, nuclear
membrane
•Both involve formation of spindle
fibers
DIFFERENCES
• Meiosis produces daughter cells that
have 1/2 the number of chromosomes
as the parent. Go from 2n to 1n.
• Daughter cells produced by meiosis
are not genetically identical to one
another.
• In meiosis cell division takes place
twice but replication occurs only
once.
Value of Variation
• Variation - differences between
members of a population.
• Meiosis results in random
separation of chromosomes in
gametes.
• Causes diverse populations that
over time can be stronger for
survival.
Thank you 

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