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The thrombotic effect of space
travel
By: Sebastian Maurice
Introduction • Human space travel has been attainable since the 1960’s, and efforts towards travelling to farther celestial bodies are being planned. • Several companies, including NASA, has plans to introduce touristic space flight in the near future, offering services to paying customers. • Although the idea is to allow people of many physical and medical backgrounds on flights, this might prove to be a challenge. Clinical implications of zero-gravity • The human circulatory and hemostatic system was evolved to work under earth’s gravity, however, things change in zero gravity conditions. • In zero gravity, blood becomes stagnant instead of flowing, which can increase the risk of thrombosis. • Additionally, ultrasound tests showed an extremely dilated jugular vein after travelling through space (7 times regular diameter) Clinical implications of zero-gravity, cont. • Additionally, it was shown that jugular vein pressure increased 3-3 times the normal amount. • Increases in blood pressure can lead to larger and thicker veins in the body. Evidence of thrombotic risks
• In one experiment, 6 out of 11 astronauts
were shown to have static blood flow in the jugular vein, which can lead to thrombosis. • Additionally, hypercoagulability can come about from increased blood volume (due to weightlessness) • First days in space and first days of re-entry is known to cause cardiac issues, both events are known to cause an acute phase receptor response (causing coagulation) Further delve into thrombotic risks studies • An MRI study of 27 astronauts to detect thrombotic masses in the brain showed nothing. • Additionally, decades of ultrasound imaging hasn’t revealed any thrombotic structures. • This could be due, however, to the conditions of operation in space, and the skill of the operator. • Furthermore, testing and screening for astronauts with hereditary thrombophilia is not performed, so many could pass through the cracks. Conclusion and Discussion • In conclusion, much of the data surrounding the correlation of thrombotic issues and space travel is still inconclusive, die to the difficulties of space travel. • Additionally, preventative measures for thrombosis caused by space travel is still relatively unknown, due to the niche and expensive nature of the study being done. Summary • In summary, space travel can lead to blood pooling in the body, and expanding in volume. • This can lead to dilated veins, and increased blood pressure. • The link between space travel and thrombosis still hasn’t been fully fleshed out, due to the difficulty and expense of space travel. Questions? Works Cited • Limper U, Tank J, Ahnert T, Maegele M, Grottke O, Hein M, Jordan J. The thrombotic risk of spaceflight: has a serious problem been overlooked for more than half of a century? Eur Heart J. 2021 Jan 1;42(1):97-100. doi: 10.1093/eurheartj/ehaa359. PMID: 32428936.