Scribd
Upload
2 views7 pages

UNIT 5 ( PART 3)

Uploaded by

Poorani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
2 views7 pages

UNIT 5 ( PART 3)

Uploaded by

Poorani
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 7

UNIT 5

Part 3

CONTENTS:

BOX BEHNKEN METHOD


APPLICATIONS IN PHARMACEUTICAL
FORMULATION
BOX BEHNKEN DESIGN
 Box Behnken designs are the equivalent of Plackett – Burman
designs for the case of 3- level multi- factor.
 Full factorial design is not used but samples are assigned to the
“edges” of a full factorial design space.
 In this design the treatment combinations are at the midpoint
of edges of the process space and the center .
 These designs are rotatable ( or near rotatable) and require 3
levels of each factor.
 These are designs that consists of combinations from 2^p
designs.
CONTIN..
They do not contain embedded factorial or fractional factorial design.
It incorporates three levels ( coded -1,0,+1 ).
These designs for three factors with circled point appearing at the origin and
possibly repeated for several runs.
The designs have limited capability for orthogonal blocking compared to the
central composite designs.
USES:
 With three- level multi – factor experiments.
 When it is required to economically detect large main effects,
especially when it is expensive to perform all the necessary
runs.
 When the experimenter should avoid combined factor
extremes.
 This property prevents a potential loss of data in those cases.
ADVANTAGES:
 Smaller samples sizes than CC designs.
 No unreasonable design points.

DISADVANTAGES:
 Poor predictions in the “corners” of the design space.
 Cannot create a BB design from an existing full factorial design.
 May not be a “rotatable” design.
APPLICATIONS IN PHARMACEUTICAL FORMULATION

 It is used in pharmacy relative formulation and processing.


 It is involved in formulating drug products in various forms.
 It helps the pharmaceutical scientist to understand theoretical
formulation and the target processing parameters which
ranges for each excipients & processing factors.
 Final product not only meets the requirements from the
bioavailability but also from the practical mass production
criteria.
THANK YOU …

You might also like