Scribd
Upload
6 views12 pages

Arif Aly 01 PPT

This document reviews bioadhesives for tissue repair and regeneration, discussing their types, mechanisms, applications, and challenges. Bioadhesives, derived from natural or synthetic sources, offer alternatives to traditional wound closure methods and are used in various medical applications. The paper emphasizes the importance of mechanical and biological properties in the design of bioadhesives and highlights the need for further research to optimize their clinical use.

Uploaded by

anjali81singh21
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
6 views12 pages

Arif Aly 01 PPT

This document reviews bioadhesives for tissue repair and regeneration, discussing their types, mechanisms, applications, and challenges. Bioadhesives, derived from natural or synthetic sources, offer alternatives to traditional wound closure methods and are used in various medical applications. The paper emphasizes the importance of mechanical and biological properties in the design of bioadhesives and highlights the need for further research to optimize their clinical use.

Uploaded by

anjali81singh21
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
You are on page 1/ 12

JBIT College Of Pharmacy, Dehradun.

Topic: A Review on Bioadhesives for Tissue and


Regeneration

Submitted By Submitted To
Arif Ali Miss Yati Gaur
Roll No. (Assistant Professor)
21167030010
Introduction

 Bioadhesives are substances that bond biological tissues together.


 They can be derived from natural sources (e.g., fibrin, chitosan) or synthesized
in the lab.

 Offer promising alternatives to traditional wound closure methods like sutures


and staples.

 Widely used in surgery, wound healing, and tissue engineering due to their
strong adhesion in wet environments.

 This review covers the types, mechanisms, applications, challenges, and future
prospects of bioadhesives in tissue repair and regeneration.
Types of Bioadhesives:

1. Based on Source/Origin: 2. Based on Chemical Composition:


a. Natural Bioadhesives:
 Protein-based (e.g., fibrin, gelatin)
 Protein-based adhesives.
 Polysaccharide-based adhesives. 3. Based on Application:
 Marine organism-derived adhesives.
 Medical and Surgical Adhesives
b. Synthetic Bioadhesives:  Dental Adhesives
 Industrial and Biomedical Application.
 Engineered in labs to mimic or improve upon
natural adhesives.
Mechanism Of Adhesion:
Mechanical Interlocking

Adhesive penetrates surface pores for physical grip.

Electrostatic Bonding

Attraction between opposite charges on tissue & adhesive.

Chemical Bonding

Covalent or hydrogen bonds with tissue components.

Diffusion Theory

Intermingling of adhesive and tissue molecules.

Adsorption Theory

Physical interactions (van der Waals, hydrophobic forces).

Wetting

Good surface contact is essential for strong adhesion.


Key Properties for Effective
Bioadhesives
1. Biocompatibility
Should not cause an immune or allergic reaction
Must be safe for use in living tissues
2. Biodegradability
Should degrade naturally after fulfilling its function
Degradation products must be non-toxic and easily removed from the body
3. Strong Adhesion
Must adhere firmly to both wet and dry tissues
Should work in dynamic and moist environments like blood or internal organs
4. Hemostatic Capability
Should help stop bleeding during application
Essential for use in surgeries and wound closure
Applications in Tissue Repair

1. Skin Wound Closure


 Used as an alternative to sutures or staples for cuts, burns, and
surgical incisions.
 Faster healing with less scarring.

2. Internal Organ Repair


 Useful in sealing leaks or tears in organs like the liver, lungs,
or intestines
 Can function in wet, dynamic environments

3. Neural and Spinal Cord Applications


 Bioadhesives help in protecting delicate nerve tissues during
repair
 Reduce the need for suturing fragile structures
 Example: PEG-based adhesives for spinal dura closure
Challenges and Limitations of Bioadhesives

1. Inflammatory or Immune Reactions


Some bioadhesives may cause irritation or immune response
Risk of tissue damage or delayed healing
2. Uncontrolled Degradation Rate
Some degrade too fast or too slow
Premature breakdown can fail to support healing;
slow degradation can cause complications
3. Poor Adhesion in Wet Environments
Blood and body fluids can reduce adhesion strength
Especially problematic in internal organ or vascular applications
4. Limited Mechanical Strength
Not suitable for high-stress areas like joints or moving tissues
May break or detach under pressure or motion
Aim & Objective:

Aim:
To critically review and analyze the types, mechanisms, applications, and recent
advancements of bioadhesives used in tissue repair and regeneration, highlighting their
biomedical significance and future potential in clinical settings.

Objective:
 To provide an overview of the basic concepts and classification of bioadhesives.
 To examine the physicochemical and biological properties that influence bioadhesive performance
in tissue engineering.
 To explore the mechanisms by which bioadhesives interact with biological tissues.
Methodology:

1. Literature Review Approach:


Conducted a comprehensive review of existing literature from peer-reviewed journals, books, and scientific
databases.
2. Sources and Databases:
Searched through Google Scholar
Focused on studies from 2010 to 2024 related to bioadhesives in tissue repair
3. Inclusion Criteria:
Articles on natural and synthetic bioadhesives
Studies focusing on biocompatibility, adhesion strength, clinical application, and recent innovations
English-language and full-text accessible research only
4.Data Extraction:
 Type of bioadhesive
 Mechanism of action
 Applications
Key References:

 Ghelichi, R. et al. (2020). Natural bioadhesives for biomedical applications: From nature to
nanotechnology. Advanced Healthcare Materials, 9(1), 1901437.
 Yuk, H. et al. (2019). Dry double-sided tape for adhesion of wet tissues and devices. Nature, 575,
169–174.
 Li, J. et al. (2017). Tough adhesives for diverse wet surfaces. Science, 357(6349), 378–381.
 Annabi, N. et al. (2014). Surgical materials: Current challenges and future directions. Advanced
Materials, 26(1), 85–124.
 Mehdizadeh, M. & Yang, J. (2013). Design strategies and applications of tissue bioadhesives.
Macromolecular Bioscience, 13(3), 271–288.
 Bhagat, V., & Becker, M. L. (2017). Degradable adhesives for surgery and tissue engineering.
Biomacromolecules, 18(10), 3009–3039.
 Zhao, X. et al. (2017). Injectable and bioadhesive hydrogel for hemostasis and wound healing.
Chemical Reviews, 117(12), 12554–12592.
 Bré, L. P. et al. (2015). Recent advances in bioadhesives: Adhesion mechanisms and applications.
ACS Biomaterials Science & Engineering, 1(5), 464–472.
 Bré, L. P. et al. (2015). Recent advances in bioadhesives: Adhesion mechanisms and applications.
ACS Biomaterials Science & Engineering, 1(5), 464–472.
 Ryou, M., & Thompson, C. C. (2010). Tissue adhesives: A review. Techniques in Gastrointestinal
Endoscopy, 12(1), 33–37.
Abstract
The increasing prevalence of tissue loss caused by various factors such as chronic illnesses, traumatic injuries, and
surgical interventions has created an urgent demand for innovative biomaterials that can support effective tissue
repair and regeneration. Traditional methods of tissue reconstruction often face limitations such as inadequate
integration with surrounding tissues, delayed healing, and the risk of infection or failure. In response to these
challenges, the field of regenerative medicine has witnessed the emergence of a novel class of biomaterials known
as regenerative bioadhesives.

These next-generation bioadhesives are specifically designed to offer a dual function: strong and reliable adhesion
to biological tissues, coupled with the ability to actively participate in and support the tissue regeneration process.
Unlike conventional adhesives that merely provide mechanical support, regenerative bioadhesives interact
dynamically with the biological environment, promoting cellular activity, tissue remodeling, and healing. Their
applications are vast, ranging from enhancing wound closure in skin injuries to supporting the regeneration of
complex, load-bearing musculoskeletal structures such as tendons and intervertebral discs.
This paper emphasizes the importance of both mechanical and biological considerations in the design and
development of regenerative bioadhesives. Mechanical properties, such as elasticity, strength, and durability, are
critical to ensure that the adhesive can withstand the dynamic stresses present in various body tissues.
Simultaneously, biological compatibility—ensuring that the materials do not provoke immune responses and are
conducive to cell growth and differentiation—is equally vital.

To illustrate the practical utility of these materials, this work presents several case studies focusing on the
regeneration of skin, tendons, and intervertebral discs. These examples highlight how bioadhesives can be tailored
to meet the specific demands of different tissue types. In conclusion, while regenerative bioadhesives have already
demonstrated promising results, continued interdisciplinary research is essential to address current limitations,
optimize performance, and expand their clinical applications. The future of regenerative medicine may well be
shaped by the advancements in this innovative class of biomaterials.
Thank you so much

You might also like