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Red Cell Indices Presentation

The document provides a comprehensive overview of evaluating anemia and related hematological disorders, focusing on red cell indices, reticulocyte count, iron studies, and vitamin B12 and folate. It discusses the clinical significance of these parameters in diagnosing different types of anemia and highlights the importance of testing for deficiencies. Key components and interpretations of iron studies, as well as the functions and testing for B12 and folate, are also covered.

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jefinjoseph01
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2 views12 pages

Red Cell Indices Presentation

The document provides a comprehensive overview of evaluating anemia and related hematological disorders, focusing on red cell indices, reticulocyte count, iron studies, and vitamin B12 and folate. It discusses the clinical significance of these parameters in diagnosing different types of anemia and highlights the importance of testing for deficiencies. Key components and interpretations of iron studies, as well as the functions and testing for B12 and folate, are also covered.

Uploaded by

jefinjoseph01
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Red Cell Indices, Reticulocyte

Count, Iron Studies, B12 & Folate


• A Comprehensive Overview
• Presented by: [Your Name]
• Date: [Presentation Date]
Introduction
• - Importance of evaluating anemia and related
hematological disorders
• - Overview of key parameters:
• • Red cell indices
• • Reticulocyte count
• • Iron studies
• • B12 and folate
Red Cell Indices – Overview
• - Measured as part of the Complete Blood
Count (CBC)
• - Parameters:
• • MCV (Mean Corpuscular Volume)
• • MCH (Mean Corpuscular Hemoglobin)
• • MCHC (Mean Corpuscular Hemoglobin
Concentration)
• • RDW (Red Cell Distribution Width)
Red Cell Indices – Clinical
Significance
• - MCV: Classifies anemia (microcytic,
normocytic, macrocytic)
• - MCH & MCHC: Assess hemoglobin content
• - RDW: Indicates anisocytosis
• - Diagnostic aid in anemia types
Reticulocyte Count
• - Immature red blood cells, indicator of bone
marrow activity
• - Normal Range: ~0.5–2.5%
• - Corrected Reticulocyte Count: Adjusted for
anemia
• - Reticulocyte Production Index (RPI)
Clinical Use of Reticulocyte Count
• - High: Hemolysis, blood loss
• - Low: Bone marrow suppression, aplastic
anemia
• - Helps differentiate causes of anemia
Iron Studies – Components
• - Serum Iron
• - TIBC (Total Iron Binding Capacity)
• - Transferrin Saturation
• - Serum Ferritin – key marker of iron stores
Iron Studies – Interpretation
• Condition | Serum Iron | TIBC | Ferritin |
Transferrin Saturation
• Iron Deficiency | Low | High | Low | Low
• Anemia of Chronic Disease | Low |
Low/Normal | Normal/High | Low
• Hemochromatosis | High | Low | High | High
Vitamin B12 & Folate – Functions
• - DNA synthesis
• - Neurological function (B12)
• - RBC maturation
• - Deficiency → macrocytic anemia
B12 & Folate – Deficiency and
Testing
• - Causes: Malabsorption, diet, medications
• - Symptoms: Fatigue, glossitis, neurological
signs (B12)
• - Tests: Serum B12, Serum Folate,
Homocysteine & Methylmalonic Acid (B12)
Summary
• - Red cell indices classify anemia
• - Reticulocyte count reflects marrow response
• - Iron studies differentiate iron deficiency vs
other types
• - B12 and folate are crucial for macrocytic
anemia evaluation
References
• - Harrison’s Principles of Internal Medicine
• - Kumar & Clark’s Clinical Medicine
• - WHO Guidelines on Anemia

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