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Antipsychotics Presentation POWER POINT

The document is a presentation on antipsychotic drugs by Group Three from the Newgate College of Health Technology's Pharmacy Department. It covers the definition, mechanism of action, classification, adverse effects, and pharmacokinetic profiles of typical and atypical antipsychotics, along with their indications and contraindications. The conclusion emphasizes the importance of careful selection and monitoring of antipsychotic medications to improve patient outcomes.

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zalihajibrin11
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2 views14 pages

Antipsychotics Presentation POWER POINT

The document is a presentation on antipsychotic drugs by Group Three from the Newgate College of Health Technology's Pharmacy Department. It covers the definition, mechanism of action, classification, adverse effects, and pharmacokinetic profiles of typical and atypical antipsychotics, along with their indications and contraindications. The conclusion emphasizes the importance of careful selection and monitoring of antipsychotic medications to improve patient outcomes.

Uploaded by

zalihajibrin11
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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NEWGATE COLLEGE OF

HEALTH TECHNOLOGY

KM8,OFF MINNA BIDA ROAD,MINNA NIGER STATE

DEPARTMENT OF PHARMACY TECHNICIAN

SIWES DEFENSE PRESENTATION ON:


ANTIPSYCHOTIC DRUGS

BY: GROUP THREE

SUBMITTED TO
PHARMACY DEPARTMENT
Group Members
 Zaliha Jibrin (2022\PHA\3793)

 Ibrahim Yusuf Zhuru (2022\PHA\3590)

 Hamza Zawata Maiturare (2022\PHA\3367)

 Halima Abdullahi (2022\PHA\3390)

 Precious Timothy Alkali (2022\PHA\3353)

 Rebecca Jonathan Dufia (2022\PHA\3379)


Outlines
• Introduction to antipsychotic
• Definition
• Mode of action
• Classification
• Moa of the classification
• Adverse effects
• Side effect
• Contraindications
• Indications
• Key difference
• Pharmacokinetic profile
• Conclusion
• Reference
Introduction to Psychosis
 Definition: Derived from Greek words
'physche' (mind) and 'osis' (disorder).
 Psychosis is a mental health condition

characterized by a disconnection from


reality.
Symptoms:
 - Hallucinations
 - Delusions
 - Disorganized thinking
 - Disorganized behavior
Antipsychotic Drugs

 Definition: Medications used to manage


symptoms of psychosis and related disorders.
 Indications:

- Schizophrenia
- Bipolar disorder
- Severe depression
- Anxiety disorders
 Effects: Regulate thought patterns, mood

stability, emotional responses, and behavioral


control.
Mechanism of Action

 Typical Antipsychotics:
 - Block dopamine D2 receptors in the brain.
 - Reduce positive symptoms of psychosis (e.g.,
hallucinations, delusions).

 Atypical Antipsychotics:
 - Block dopamine D2 and serotonin 5-HT2A
receptors.
 - Target both positive and negative symptoms of
psychosis.
Classification of Antipsychotics

 1. Typical (First-Generation).
 - MOA: Block D2 receptors.
 2. Atypical (Second-Generation)
 - MOA: Block D2 and 5-HT2A receptors.
Typical Antipsychotics

 Examples: Haloperidol, Fluphenazine,


chlorpromazine, perphenazine
 Adverse effect;Extrapyramidam, neurolepctic
malignant syndrome
 Contraindication; coma and severe nervous
system depression ,parkinsons’ disease,
hypersensitivity
 Indications: Schizophrenia, severe agitation.
 Side Effects: dry mouth, drowsiness, dizziness,
sedation, constipation, weight gain
Atypical Antipsychotics

 Examples:Risperidone,Clozapine,Olanzapine,Quetiapin
e.
 Adverse effect: metabolism syndrome agranulocytosis
and cardiovascular events
 Indications: Schizophrenia, bipolar disorder,severe
depresssion
 Contraidication :severe liver and kidney disease,
hypersentivity, pregnacy and breast feeding

 Side Effects: Weight gain, sedation, increase in


appetite , gastrointestestinal issue, erectile disfuntion
and decrease libido , amenorrhea and dysamenorrhea
Pharmacokinetic Profiles
 Drug 1: Haloperidol (Typical Antipsychotic)
 - Bioavailability (F): 60-70%
 - Maximum concentration (Cmax): 4-8 ng/ml
 - Time to reach Cmax (T.Cmax): 2-6 hours
 - Half-life (T½): 24 hours
 - Volume of distribution (Vd): 14-24 L/kg
 - Clearance (Cl): 0.5-1.5 L/h/kg

 Drug 2: Carbamazepine (Mood Stabilizer)


 - Bioavailability (F): 75-85%
 - Maximum concentration (Cmax): 4-8 ng/ml
 - Time to peak (Tmax): 4-8 hours
 - Half-life (t1/2): 25-65 hours
 - Volume of distribution (Vd): 0.8-1.9 L/kg
 - Clearance (Cl): 0.2-0.6 L/h/kg
Key difference

 Mechanism of action
 Side effect profile
 Efficacy
Conclusion
In conclusion Antipsychotics are cornerstone
of psychosis treatment, offering substantial
relieve of symptoms and improving quality of
life. However they come with significant side
effect requiring careful selection,
individualized dosing, and regular monitoring.
Recommendation: take care of your mental
wellbeing , remember health is wealth .
Reference

 https://pubmed.ncbi.nlm.nih.gov
 https://nami.org
 https://www.pharmacologyeducation.or
g
 THANK YOU FOR LISTENING

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