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Tableting Behavior of Excipients

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Sadatur Rahman
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0 views

Tableting Behavior of Excipients

Uploaded by

Sadatur Rahman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Tableting Behavior of

Freeze & Spray-dried


Excipients in
Pharmaceutical
Formulations
Presented By: Saimoon Nahar Mim
Institution: Jagannath University

Presented At: Eskayef Pharmaceutical Ltd.

Date: 2nd June, 2025


Overview of Topics
 Introduction to Excipients
 Types of Excipients
 Importance in Formulations
 Freeze-Dried Excipients
 Spray-Dried Excipients
 Comparison of Freeze vs. Spray-Dried Excipients
 Impacts on Tableting Behavior
 Challenges and Future Directions
 Conclusion and Key Takeaways
Introduction to Excipients
Definition of Excipients
Excipients are inactive substances formulated alongside the
active ingredient in a drug.

Types of Excipients
Excipients can be classified into functional categories such as
fillers, binders, disintegrants, and lubricants.

Importance in Formulations
The choice of excipient significantly affects the tablet's
mechanical strength, dissolution rate, and overall
bioavailability.
Freeze-Drying Process Overview
1 Overview of Freeze- 2 Characteristics of 3 Applications in
Drying Freeze-Dried Formulations
Dehydration process that Excipients Ideal for rapid
disintegration and solubility
removes moisture by Enhanced porosity and
in oral and parenteral
freezing and sublimating it surface area lead to better
dosage forms.
under vacuum. solubility and absorption.
Spray-Drying Process
Characteristics of Spray-
Dried Excipients

These excipients exhibit spherical


morphology and enhanced flow
Overview of Spray- 2 properties, aiding tablet
Drying compression and product
Spray-drying transforms uniformity.
liquid formulations into dry 1
granules or powder by
atomizing the liquid and
Applications in
evaporating the solvent 3
Formulations
quickly.
Widely used in solid dosage
forms requiring controlled release
profiles and improved wetting
characteristics.
Comparison of Freeze and
Spray-Dried Excipients
Physical Dissolution
Compatibility
Properties Profiles
Higher porosity
with Actives
Freeze-dried
in freeze-dried Freeze-dried
excipients may
excipients excipients may
enhance
affects stabilize
dissolution
compressibility thermolabile
rates; spray-
and hardness. drugs better
dried supports
than spray-dried
controlled
ones.
release.
Impacts on Tableting Behavior
Characteristic Freeze-Dried Spray-Dried

High due to porous structure


Compressibility (plastic deformation) Good due to particle size and shape

High tensile strength at low Moderate to high depending on


Compactibility compression force formulation

Poor – may cause problems in die Excellent – ideal for high-speed


Flowability filling tableting

Tablet Uniformity Can be variable due to poor flow High consistency

Lubricant Sensitivity Less due to open pore structure Can be more sensitive

Controlled based on excipient


Challenges and Future Directions

Stability Concerns Regulatory Research and


The stability of formulated Considerations Development
products using these excipients The regulatory landscape Ongoing studies are crucial to
poses challenges, particularly affecting the usage of freeze- better understand the
concerning moisture absorption dried and spray-dried excipients interactions between excipients
and shelf-life, necessitating is evolving, which may impact and active pharmaceutical
further research. the development of new ingredients to optimize
formulations and processes. formulations for specific
therapeutic applications.
Conclusion of Pharmaceutical Formulation
Insights
Future Outlook

Continued innovation and


research in excipient technology
will support advancements in

Key Findings 2 drug delivery systems, enhancing


patient outcomes and
Understanding the behaviors therapeutic effectiveness.
of freeze-dried and spray- 1
dried excipients is pivotal in
the design of effective
Final Remarks
pharmaceutical formulations
that meet clinical needs. Selecting the appropriate
3 excipients based on their
tableting behavior is essential for
achieving desired formulation
Thank You

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