This document compares and contrasts statistical learning and machine learning. While both aim to understand relationships between variables from data, they differ in their assumptions, techniques, and predictive power. Statistical models rely on assumptions of linearity, normality, and independence, while machine learning algorithms make fewer assumptions and can find complex, non-linear patterns in large datasets. Machine learning also requires less human effort than statistical modeling and generally has stronger predictive capabilities due to operating independently of assumptions. While distinct approaches, machine learning and statistical modeling are becoming increasingly similar and integrated in practice.