This document provides guidance for advertisers, agencies, and publishers on developing a programmatic advertising strategy. It outlines different operational models for both the buy-side and sell-side, including using agency trading desks, independent trading desks, managed services, building an in-house team, or outsourcing to a supply-side platform. It also discusses the importance of understanding audience data and how to leverage programmatic tools to develop successful strategies. Ultimately, the document argues that programmatic has the potential to increase efficiency, unlock value from data, and foster collaboration across the advertising industry.