This document discusses trends related to the future of work and organizations in the 21st century. It notes that 47% of traditional jobs will be gone by 2020 and that 70% of today's employees find no meaning in their work. New technologies like artificial intelligence, robotics, and 3D printing will continue to automate jobs. However, the future is also uncertain and bright with new opportunities. It suggests businesses focus on innovation, entrepreneurship, and massive transformative purpose to make work more meaningful and future-proof their organizations against disruption. Hackathons are proposed as a way to train 21st century skills while solving companies' biggest problems.