Platelet Rich Plasma (PRP) for Treatment of Knee Arthritis
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This document discusses treatment options for knee arthritis, including traditional methods like medications and surgery as well as regenerative techniques using platelet rich plasma (PRP). It notes that 10 million Americans have knee arthritis and $30 billion is spent yearly on knee replacements. Traditional methods are criticized for their side effects, while PRP is presented as a natural alternative that stimulates the body's healing processes, reduces inflammation, strengthens cartilage, and can avoid or delay more invasive options like surgery. PRP is described as an autologous treatment that has advantages over medications in stimulating normal healing pathways without inherent negative effects.
Platelet Rich Plasma (PRP) for Treatment of Knee Arthritis
- 1. Knee Arthritis - Treatment and Joint Preservation with PRP Regenerative Medicine and Joint Preservation Center of Santa Rosa Raymond Severt, M.D. 1144 Sonoma Avenue, Suite 121 Santa Rosa, California, 90025 (707) 978-4322 Heal Naturally
- 2. Knee Arthritis is a BIG Problem 10 million in US have knee arthritis $30 billion spend yearly on knee replacements Should we keep treating it with the “traditional” methods? Or should we treat it in a way that can use the body’s own healing ability without all the typical side-effects?
- 3. Regenerative Medicine Offers groundbreaking techniques to treat and control arthritis Avoid more invasive treatment options
- 4. Normal Knee Knee is a critical joint Commonly damaged Commonly develops arthritis Cartilage is smooth and strong/resilient Ligaments maintain stability Meniscus provides cushioning Good viscosity of fluid
- 5. Knee Arthritis Cartilage wears out often to bone Inflammation develops in joint Reduced lubrication/cushioning - hyaluronic acid Knee deforms and becomes unstable Knee becomes painful, swollen, and stiff
- 6. “Traditional” Treatment What is typically offered to patients Rest, Ice, Braces Physical Therapy Medications NSAID Corticosteroid Injections Surgery
- 7. Is There Something Wrong With These “Traditional” Treatment Methods? Rest, Ice, Braces - NO Physical Therapy - NO Medications - YES Corticosteroid Injection - YES Surgery - YES
- 8. Rest, Icing, Bracing Certainly helpful No negative effects Comforting Reduces pain Patient can do these on their own at their own discretion
- 9. Physical Therapy Certainly helpful Strengthens Mobility Home Exercise Program Prevents further injury Often invaluable for prevention and to help in recovery
- 10. Medications- NSAIDs Prescription and OTC Have MANY side effect Ulcers Bleeding Heart Attack Stroke Kidney Liver One of highest causes of hospitalization and death in elderly Expensive Many pulled off market because of safety issues (Vioxx, Bextra)
- 11. Corticosteroid Injections Depo-Medrol, Kenalog, Celestone Do reduce inflammation - but for a very limited timeframe COMPLICATIONS - not trivial! “flare reaction” soft tissue damage - ligaments, tendons cartilage deterioration - decreased cartilage cell viability - softens cartilage osteoporosis - softens bone skin atrophy - depigmentation These complications produce effects that are completely contrary to what the patient needs and wants!
- 12. Medications - Oral and Injectables Produce effects in the body that are completely “unnatural” Produce effects that are damaging Block normal inflammatory cascades Block healing mechanisms Block biological pathways that are necessary for proper healing of damaged tissue
- 13. Surgery May be needed in some situations - with proper indications! Significant risks Invasive Once done is “irreversible” Long recovery Complications
- 14. Surgery - Cost Knee Replacement $40K - out of pocket cost - several $100’s or $1,000’s Is surgery done too often? Knee arthroscopy - indications, findings, results? Repeat/Revision Surgery
- 15. What About Platelet Rich Plasma Treatment - PRP A natural way to stimulate the body to heal damaged tissue
- 16. How Does PRP Work For Arthritis? Stimulates body's natural healing process Balances inflammation/anti- inflammatory cascades Reduces inflammation and pain Stimulates chondrocytes to strengthen cartilage Increased hyaluronic acid secretion and superficial zone protein Inhibits and reverses osteoarthritis pathogenesis pathways (interleukin, aggrecan, nuclear factor B)
- 17. PRP Stops and Reverses the Arthritic ProcessStrengthens cartilage - increases cartilage cell viability Improves protective viscosity of joint fluid Reverses osteoarthritic pathways MRI and functional studies have shown that PRP halts the progressive thinning of cartilage and improves function.Halpern, et al., Clin J Sport Med, 2013
- 18. PRP Advantages Autologous Natural Safe Stimulates/activates the normal healing pathways that the body already has Does not have the inherent negative effects seen with medications (oral or injectable) Can avoid or delay surgery
- 19. PRP Advantages Completely outpatient setting Can initiate rehabilitation quickly Long lasting results Can be safely repeated if needed
- 20. PRP for Knee Arthritis Not all PRP’s are alike Intra-articular PRP must be appropriately prepared Reduce inflammation, stimulate chondrocytes, increase hyaluronic acid production Proper experience and equipment needed Reduce erythrocyte and granulocytes in preparation Maintain high platelet and growth factor levels
- 21. PRP for Knee Arthritis A natural way to treat the symptoms of knee arthritis and to help preserve the structure and function of the knee in its natural state for an extended period of time.
- 22. Regenerative Medicine and Joint Preservation Center 1144 Sonoma Avenue Suite 121 Santa Rosa, CA 95405 (707) 978-4322 OrthoRegenSR.com Maintain. Preserve. Sustain.