PhoneGap allows developers to build mobile apps using HTML, CSS, and JavaScript instead of relying on platform-specific languages. It works by wrapping web apps in a native container, allowing access to device capabilities like the camera and geolocation. PhoneGap Build provides a cloud-based service for compiling PhoneGap apps so developers don't need to install SDKs locally. The presentation covered the PhoneGap workflow, tools like PhoneGap Dev Browser and Sleight, and the roadmap for future releases.