Ijmas 560

INTERNATIONAL JOURNAL OF MEDICAL AND APPLIED SCIENCES
E-ISSN:2320-3137
www.earthjournals.org Volume 3, Issue 4, 2014
114
Case Report
BILATERAL PRIMARY RENAL BURKITT LYMPHOMA
PRESENTING AS NEPHROTIC SYNDROME WITH
TUMOUR LYSIS SYNDROME
1.Shreeniwas S. Raut, 2.Shailesh S. Talati,3.Sonia K. Parikh,4.
Vashishth P. Maniar, 5. Vandana L. Gohel, 6.Divesh M. Goyal
1.DM , Resident doctor,2. MD, Professor, 3.DM, Associate Professor, 4. DM,
resident doctor , 5. DM, Resident doctor,6.DM, Resident doctor,
Gujarat Cancer Research Institute, Ahmedabad
Corresponding Author: Dr. Shreeniwas S. Raut, Shahu Vasahat, near PMC school no. 111, Lakshmeenagar,
Pune: 411009.
Abstract :
We report a case of seven year female child presented with nephrotic syndrome along with tumour lysis
syndrome. There are some case reports worldwide with the resembling presentation but the diagnosis remains
controversial in majority of them. We report the presentation of this case as misdiagnosis, hence a mistreatment
and further difficulty in interpretation of stage of the disease due to administration of steroids. The patient was
diagnosed as bilateral primary renal Burkitt lymphoma after a delay of 2 months after her presentation to
hospital for her symptoms. She had persistent renal dysfunction and was started on chemotherapy but had poor
outcome. It may suggest the individualisation of the patient for treatment because such patient may not tolerate
the established protocols of chemotherapy for this disease, due to established renal dysfunction. We propose a
modification of previously proposed criteria by Malbrain for diagnosis of primary renal lymphoma (PRL) and
suggest a better term ‘probable primary renal lymphoma’ (PPRL) because the diagnosis of PRL is of
controversy as well as exclusion. We delineate the criteria for PPRL.
Keywords: Renal Burkitt Lymphoma ,
CASE REPORT
A seven year old girl with 13.5 kilogram weight presented with breathlessness since 2 days.
She had history of low grade fever, progressive distension of abdomen, night sweats and not
eating well since one month. She had no history of bleeding, rash, oliguria. Since one week
she had few episodes of vomiting, swelling over feet and puffiness of face. There was no
palpable lymphadenopathy. She had no past or family history of any medical illness. On
general examination she had pallor. There was no icterus, cyanosis or clubbing. She had
anasarca. She also had tachycardia, tachypnea & hypertension (blood pressure 142/104 mm
of Hg). Cardiovascular examination was normal. Respiration was laboured but breath sounds
were normal. On abdominal examination only positive sign was that both kidneys were
palpable, ballotable with smooth surface and were non tender.
Her investigations revealed haemoglobin (HB) 5.6 gm/dL, total leukocyte count
(TLC ) 16000/µL,platelet count (PLC) 134000/µL, serum creatinine ( Cr) 6.5 mg/dL, blood
urea nitrogen (BUN) 82 mg/dL, total protein (TP) 5 g/dL, serum albumin (ALB) 1.3 g/dL,
serum sodium (NA) 134 mmol/L, serum potassium (K) 6.4mmol/L, liver function test (LFT)
normal and arterial blood gases (ABG) showed severe metabolic acidosis with respiratory

E-ISSN:2320-3137
115
alkalosis. Uric acid (UA) level was 54 mg/dL. Urine analysis showed microhematuria along
with nephrotic range proteinuria. Ultrasonography of neck, thorax, abdomen and pelvis was
carried out which showed only abnormality of bilateral mildly enlarged kidneys with slightly
altered echotexture.
This patient received blood transfusion, was subjected to peritoneal dialysis and
stabilised subsequently. She was treated with steroids (ranging equivalent to 1-2 mg/ kg of
prednisolone per day for 2 months) for nephrotic range of proteinuria suspecting childhood
nephrotic syndrome (nephrotic range proteinuria, oedema and hypertension) which is usually
responsive to steroids. Further she was kept on dialysis with biweekly schedule. Due to
persistently high creatinine, low urine output and microhematuria, she had undergone renal
biopsy, the report of which was suggestive of malignant round cell tumour. So the severe
hyperuricemia and hyperkalemia on presentation was actually tumour lysis syndrome.
Till this moment this patient was being treated at nephrology centre and was labelled
as acute uric acid nephropathy. Positron emission tomography (PET scan) was carried out
without contrast which showed no active uptake in any part of body. After this report of
malignancy she was transferred to oncology setting but after a long duration of time
comprising about two months from initial presentation.
The experts in pathology in our oncology setting reviewed the histopathology
specimen. Immunohistochemistry (IHC) showed leukocyte common antigen (LCA) –
Positive, CD20 (Pan B) – Negative, CD2 – Negative, MIB1 - Positive (in around 90-95 %
cells), CD 79a – Negative. IHC diagnosis was given as high grade lymphoma with likelihood
of Burkitt type lymphoma. However, CD20 was negative may be due to poorly processed
tissue. At this moment patient’s reports revealed HB 9.6 g/dl, TLC12700 /µL, PLC 78000
/µL, Polymorphs 81 %, Lymphocytes 16 %, Monocytes 2 %, Eosinophils 1 %, UA
11.36 mg/dL, NA 139.6 mmol/L, K 5.93 mmol/L, chloride (Cl) 103.1 mmol/L, BUN 39.44
mg/dL, Cr 7.19 mg/dL. Tests for Human immunodeficiency virus, Hepatitis B and Hepatitis
C were negative; Serum Calcium (Ca) 8.99 mg/dl, Magnesium (Mg) 3.2 mg/dl, serum lactate
dehydrogenase (LDH) 1019 U/L, Blood Sugar (RBS) 83 mg/dL. Except hypoalbuminemia
her LFT was normal.
Further, bone marrow examination showed both marrow aspiration and biopsy was
normocellular and uninvolved by the malignancy. Repeat ultrasonography of neck , thorax,
abdomen and pelvis showed the presence of bilateral mild pleural effusion, enlarged liver (16
cm in span and normal echo pattern), and mild bilateral enlargement of both kidneys (Right
kidney- 93X37 mm and left kidney- 91X43 mm). Both kidneys showed raised cortical
echogenicity with preserved corticomedullary differentiation suggesting medical renal
disease. Mild ascites was seen. Magnetic resonance imaging of brain and cerebrospinal fluid
cytology was normal. Repeat PET scan without contrast showed only mild bilateral
ametabolic pleural effusion without any active uptake in the whole body. She was now
started on steroids as a part of chemotherapy. Her urine output was 200 millilitre/ day. She
was on dialysis support.
We planned for her chemotherapy of LMB 96- intermediate risk protocol. Persistent
renal dysfunction not responding to steroids, even in the setting of normal PET scan was
considered as residual disease and the objective of further treatment was to cure the patient
which will reverse her renal function to normal and make her dialysis free [1].
The initial phase of chemotherapy consisting of cytoreductive cyclophosphamide,
vincristine and steroid was administered. After 48 hours of receiving cyclophosphamide
patient was puffed up and urine output being less than 75 mL/ per day. She was
hemodialysed for that. Next day her investigations showed UA 6.22 mg/dL, Cr. 3.42 mg/dL,
HB 6.4 g/dL, TLC 1400 /µL, PLC 18000 /µL, polymorphs 40 %, absolute neutrophil count

E-ISSN:2320-3137
116
(ANC) 500/µL. She had few episodes of rice watery stools. Considering neutropenia she was
started on antibiotics and filgrastim support.
A
B
C
D
E
F
Figure 1. Histopathology (A) and Immunohistochemistry (B-F) of renal biopsy sample. (A)
Paraffin section showing diffuse monotonous pattern of growth of medium sized cells with
round nuclei, dispersed chromatin and basophilic cytoplasm. (B) CD2 negative (C) CD20
negative (D) CD79a negative (E) LCA positive (F) MIB1 positive in 90-95 % cells

E-ISSN:2320-3137
117
Five days after receiving cyclophosphamide she was subjected for next
hemodialysis. Just after dialysis, this patient became breathless, tachypnic, hypotensive,
hypoxemic and her sensorium was altered. She was put on antibiotics, ionotrpic support and
expired while transferring to intensive care unit.
DISCUSSION
Kandel et al 1987 reported that it is reasonable to assume that renal lymphoma can be
a primary lesion; almost all patients with primary renal lymphoma will develop extrarenal
lymphomatous disease shortly after diagnosis of their renal tumour; and survival for more
than 1 year after diagnosis is rare [1].
The criteria for PRL (Malbrain et al, 1994) are as follows: (1) renal failure as the
initial presentation, (2) bilateral enlargement of the kidneys without obstruction and other
organ or nodal involvement, (3) diagnosis only made by renal biopsy, (4) absence of other
causes of renal failure, and (5) rapid improvement of renal function after radiotherapy or
chemotherapy [2].
As per Dawson criteria, lymphoma is said to be primarily extra nodal if 1) absence of
palpable superficial lymph nodes on first physical examination; 2) absence of mediastinal
lymphadenopathy detected on plain Chest X-ray; 3) dominant lesion at extra nodal sites; 4)
involvement of lymph nodes in the vicinity of the primary lesion; and 5) white blood cell
(WBC) count within normal range [3].
The pathogenesis of primary renal lymphoma (PRL) is poorly understood. One view
is that a chronic infection in the kidney recruits lymphoid cells into the renal parenchyma,
during which an oncogenic event takes place (Duannay, 1940). Another explanation is that
lymphomas arise in the renal capsule, which is rich in lymphatics, and invade the renal
parenchyma secondarily (Salem et al., 1993). Another possible origin of primary renal
lymphoma is a lymphomatous process in the perirenal adipose tissue with secondary
involvement of the kidney (Betta et al, 1986) [4].
The presentations of the patients reported are in adults are mostly after surgery for
solitary renal mass. Other patients presented as rheumatic disease, postrenal transplant
lymphoma, abdominal pain, B symptoms, adjacent lymphadenopathy, glomerulonephritis,
solitary metastasis. In adults mostly single kidney was involved and in children there was
bilateral renal involvement. Investigators reported many classes of non-Hodgkin lymphoma
which include large, small, intermediate and mixed cell types with high, intermediate or low
grade histology. The neoplastic lymphoid cells may express both B and T immunoblastic
phenotypes; primary renal Hodgkin lymphoma has also been reported. Renal biopsy is
important in assessing the diagnosis of PRL as well as of acute renal failure for bilateral
lymphomatous infiltration of the kidneys. Up to now, there is no standard treatment modality
for this entity since the small number of cases reported. Multidrug chemotherapy is
mandatory for high grade lymphoma and when the disease is diagnosed preoperatively. High
dose chemotherapy in the future may offer a curative approach in primary bilateral renal
disease and without end-stage renal disease. Survival is extremely poor since 75% of patients
die less than 1 year after operation. Prognosis may be improved by early detection of disease
and by performing systemic chemotherapy [5].
In our patient, obstructive nephropathy was promptly excluded by ultrasonography.
The presence of extensive hyperuricemia (serum uric acid >20 mg/dl) and uric acid crystals
rises another differential of uric acid nephropathy. There is possibility of compression of
renal arteries by lymphoma and it may cause hypertension but in our case the disease was not
documented on PET scan. The presence of hypertension, nephrotic range proteinuria and
oedema lead to a diagnosis of nephrotic syndrome. Eventually, the presence of enlarged

E-ISSN:2320-3137
118
kidneys and Histopathological evidence of Burkitt lymphoma clearly fixed the final diagnosis
of primary renal lymphoma as the cause of renal failure. The prognosis in these patients is
usually poor with most patients dying within 9 months of presentation. Our patient had death
within 4 months of presentation. Malbrain criteria needs slight modification as it is not fully
satisfied in every reported case. Some reported cases do not show renal failure. Not all
patients had good response to therapy. The renal dysfunction once occurred may not recover
necessarily if there is some permanent damage to kidney due to severe hyperuricemia in
tumour lysis.
Thus we come to a conclusion that PRL is a diagnosis of controversy and exclusion.
So we suggest the better term ’possible primary renal lymphoma (PPRL)’ and the criteria for
it can be proposed as (1) unilateral or bilateral involvement of the kidneys, (2) diagnosis
made by renal biopsy, (3) absence of other causes of renal failure if patient presents with
renal failure, (4) absence of palpable superficial lymph nodes on first physical examination,
(5) absence of mediastinal lymphadenopathy, (6) dominant lesion at kidney, (7) involvement
of lymph nodes in the vicinity of the kidney; and (8) white blood cell (WBC) count within
normal range.
CONCLUSION
Any patient who presents with nephrotic syndrome with tumour lysis syndrome should be
vigilantly exercised with the workup to rule out malignancy. A very high level of uric acid
should point towards severe tumour lysis and should arise the suspicion of Burkitt lymphoma.
The treatment of Burkitt lymphoma and non-malignant nephrotic syndrome is totally
different; hence the treatment plan should be decided as much as early. The misdiagnosis and
treatment in wrong direction may become a cause for poor outcome. The determination of
residual disease in presence of persistent renal dysfunction and PET negative cases needs
more exploration. The criteria proposed previously by malbrain needs a modification and
hence we proposed a modification of those criteria.
References
1. Kandel LB, McCullough DL, Harrison LH, et al. Primary renal lymphoma. Does it exist? Cancer 1987;
60:386-91.
2. Malbrain ML, Lambredcht GL, Daelemans R, et al. Acute renal failure due to bilateral lymphomatous
infiltrates. Primary extranodal non-Hodgkin’s lymphoma (p-EN-NHL) of the kidneys: Does it really exist?
Clin Nephrol 1994; 42:163-169.
3. Dawson IP, Cornes JS, Morson BC. Primary malignant lymphoid tumours of the intestinal tract. Report of
37 cases with a study of factors influencing prognosis. Br J Surg. 1961; 49: 80–9.
4. Shakeeb AY, Saad ZU, Shahryar A, et al. Renal Involvement in Non-Hodgkin’s Lymphoma: The Shaukat
Khanum Experience. Asian Pacific J Cancer Prev 2007; 8:249-252.
5. Porcaro AB, D’Amico A, Novelia G, et al. Primary lymphoma of the kidney. Report of a case and update of
the literature. Arch Ital Urol Androl 2002; 74:44-7.

Ijmas 560

More Related Content

What's hot (20)

Viewers also liked (11)

Similar to Ijmas 560 (20)

More from Earthjournal Publisher (20)

Recently uploaded (20)

Ijmas 560