Joe Betts-LaCroix at Health Extension Salon #1
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The document provides an overview of the ENCODE project, which aims to identify the functions of the non-coding regions of the human genome. Despite significant funding and progress, only about 10% of the project is completed, highlighting challenges such as variations among individuals and the complexity of cellular functions. The project emphasizes the importance of standardized experimental methods and public sharing of results while acknowledging past issues related to experimental practices.
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Joe Betts-LaCroix at Health Extension Salon #1
- 1. Brief Intro to the ENCODE project Joe Betts-LaCroix
- 2. History 1953 Watson & Crick discover structure of DNA 1977 Sanger Sequencing 1990 – 2001 Human Genome Project 2003 – 2012 ENCODE PROJECT
- 3. $185 Million 3 orders of magnitude < Apollo
- 5. Bad News: only 10% finished (81 years left?)
- 7. Bad News: So Much to do • variations among people • cell types within the body • more experiment types • distant interactions
- 9. More Good News: 2003 vs. 2012 (now) vs. 2021_
- 11. ENCODE coding region, aka genes:1% of genome non-coding ”Junk DNA”: 99% of genome ENCODE: • functions for 80% of genome • 70,000 promoter regions • 400,000 enhancer regions
- 12. Consortia vs. Experiments Good: • 24 Standard experiment types • Standards for types of DNA and methods • results public • results organized Bad: • do wrong stuff (cell lines, HeLa 1960’s frankenstein) • delayed incorporation of new tech & discoveries
- 13. 1961 – 1969 $100 Billion (in 2010 dollars)
- 14. $185 Million 3 orders of magnitude < Apollo