Graham Weldon discusses building highly available and scalable PHP systems. He outlines different system architectures from simple single server setups to load balanced solutions with failover. Key aspects in scaling PHP applications include using Nginx as a web server, PHP-FPM for processing, a clustered database, and caching with Varnish. Session handling requires a common storage like Redis. Weldon also promotes Rakuten's hiring needs for engineers interested in scalable architecture and DevOps.