8. Friday - Ruminant Sessions dr bill stone diamond v tech service director - future feeding for health
- 1. © Diamond V, Inc. All rights reserved. This presentation is the confidential and proprietary property of Diamond V. Diamond V does not give its consent for its distribution or license the use of its content. Diamond V Research Update Bill Stone September 21, 2018
- 2. © Diamond V, Inc. All rights reserved. Dairy and beef meta-analyses Enhanced rumen stability Improved milk fat and NDF digestibility Strengthened innate immunity Reduced incidence and severity of mastitis and respiratory disease Increased IOFC ~ $0.47 per head per day in early lact. Update on Diamond V Ruminant Research
- 3. © Diamond V, Inc. All rights reserved. Scientific Validation – Dairy Meta-analysis CHANGE IN DMI AND MILK YIELD* Difference in DMI Difference in Milk Yield Stage of Lactation kg/hea d/day P- value 95% CI kg/hea d/day P-value 95% CI First 70 days of lactation 0.62 0.003 0.21 to 1.02 1.37 0.001 0.55 to 1.80 Mid-late lactation -0.78 0.008 -1.36 to -0.21 0.98 0.049 0.01 to 1.94 * Poppy et al., 2012, J. Dairy Sci.
- 4. © Diamond V, Inc. All rights reserved. Overall Results – Peer-reviewed studies * Poppy et al., 2012, J. Dairy Sci. Item, kg. Response 95% CI P- value 3.5% FCM 1.61 0.91 – 2.31 0.001 ECM 1.65 0.95 – 2.36 0.001 Fat 0.06 0.01 – 0.10 0.009 Protein 0.03 0.00 – 0.05 0.026
- 5. © Diamond V, Inc. All rights reserved. Item Control Original Products SEM P-value Studies 20 23 -- -- Initial Weight, lb 593.2 591.8 55.0 0.43 Final Weight, lb 878.7 885.1 51.1 < 0.01 DMI, lb 16.96 17.13 1.02 < 0.0001 ADG, lb/head/d 3.06 3.26 0.135 < 0.01 Gain : Feed (Feed : Gain) 0.191 (5.24) 0.196 (5.10) 0.0099 < 0.0001 Beef meta-analysis All studies – Receiving and finishing +6.5% ADG and +2.6% Gain:Feed Wagner et al. 2016. Prof. Anim. Sci. 32:172-182.
- 6. © Diamond V, Inc. All rights reserved. Finishing Studies Item Control Original Products SEM P-value HCW, lb 655.8 662.2 16.27 0.12 Dressing percentage, % 58.0 57.9 0.12 0.85 Fat depth, in 0.46 0.45 0.02 0.46 LM area, in2 13.44 13.35 0.39 0.40 KPH, % 1.69 1.76 0.076 < 0.01 Yield Grade 2.70 2.68 0.087 0.78 ≥ Low Choice, % 63.7 73.4 6.71 < 0.05 Liver Abscess Rate, % 23.5 19.2 4.15 < 0.06 +15.2% ≥ Low Choice and -18.3% Liver Abscess Rate Wagner et al. 2016. Prof. Anim. Sci. 32:172-182.
- 7. © Diamond V, Inc. All rights reserved. Dairy and beef meta-analyses Enhanced rumen stability Improved milk fat and NDF digestibility Strengthened innate immunity Reduced incidence and severity of mastitis and respiratory disease Increased IOFC ~ $0.47 per head per day in early lact. Update on Diamond V Ruminant Research
- 8. © Diamond V, Inc. All rights reserved. Healthy rumen papillae 8
- 9. © Diamond V, Inc. All rights reserved.
- 10. © Diamond V, Inc. All rights reserved. NaturSafe Improves Ruminal Stability in Feedlot Diets Metabolism study (Latin Square design) 5 beef heifers with rumen and duodenal cannulas High grain diets Treatments Control (CON) Antibiotics (ANT, Monensin, 330 mg/d; Tylosin, 110 mg/d) NaturSafe (YFP-R, Top-dress, 18 g/d) Key findings Rumen pH increased Rumen and total tract digestion improved NaturSafe > Antibiotics Lethbridge trial, Shen et al., 2018, J Animal Sci
- 11. © Diamond V, Inc. All rights reserved.Lethbridge trial, Shen et al., 2018, J Animal Sci
- 12. © Diamond V, Inc. All rights reserved. NaturSafe Improves Ruminal Stability Lethbridge trial, Shen et al., 2018, J Animal Sci
- 13. © Diamond V, Inc. All rights reserved. Stabilizing rumen pH 16Lethbridge trial, Shen et al., 2018, J Animal Sci
- 14. © Diamond V, Inc. All rights reserved. monensin Lethbridge trial, Shen et al., 2018, J Animal Sci
- 15. © Diamond V, Inc. All rights reserved. 0 1 2 3 4 5 6 R.albus R flavefaciens F. succinogenes M. elsdenii S. ruminatium Foldchangeovercontrol XPC NutriTek * * * * * P < 0.05 Control * * Fiber digesting bacteria Lactate utilizing bacteria Brainard et al, 2014. Symposium on Gut Health in Production of Food Anim. Rumen Health Enhances Beneficial Microbial Populations (pH 5.8 to 6.0)
- 16. © Diamond V, Inc. All rights reserved. Percent NDF Digestibility Cont ANT tYFP Ruminal 41.3b 39.3b 52.9a 0.02 Total Tract 56.2b 55.1b 67.7a <0.01 19Lethbridge trial, Shen et al., 2018, J Animal Sci
- 17. © Diamond V, Inc. All rights reserved. Materials and Methods 4 groups of 8 early lactation cows Treatments Control group, 140 g/d corn XPC group, 126 g/d corn +14 g/d XPCTM NTL group, 121 g/d corn +19 g/d NutriTek ® NTH group, 102 g/d corn +38 g/d NutriTek ®
- 18. Effects of SARA and SCFP on SAA Pre SA R A 1 SA R A 1 PreSA R A 2 SA R A 2 0 20 40 60 80 100 Period SAAug/mL NTH NTL XPC Control University of Manitoba, 2017
- 19. © Diamond V, Inc. All rights reserved.22
- 20. © Diamond V, Inc. All rights reserved. Feed lot trial – Liver abscess scoring Liver abscess Classifications With O No abscesses With A- or A 1 to 2 small abscesses Up to 2 to 4 well organized abscesses With A+ Multiple large abscesses Tissue inflammation around abscess and adhesions O A A- A+ Brown et al. 1975. J. Anim. Sci. 40: 207-213
- 21. © Diamond V, Inc. All rights reserved. Liver Health 24 Positive Control1 NaturSafe P-value Carcasses, n 740 735 -- Liver abscesses, % 20.9 16.3 0.27 A - 7.5 3.7 -- A 5.3 3.9 -- A + 8.1 8.7 -- 1Positive Control contains monensin, tylosin, and a direct fed microbial. These are not included in diet of NaturSafe. Scott et al., 2017 NaturSafe-fed cattle maintained similar liver abscess rate to tylosin-fed cattle
- 22. © Diamond V, Inc. All rights reserved. Liver Health 25 Tylosin NaturSafe Liver Tested, n 3323 3154 Total abscesses, n 806 768 Liver abscesses, % 24.26 24.35 A +, % 10.30 10.29 2016 Liver Data Survey – Nebraska and Kansas feedlots during summerNaturSafe-fed cattle maintained similar liver abscess rate to tylosin-fed cattle 2016 Liver Data Survey: Nebraska and Kansas feedlots - Summer
- 23. © Diamond V, Inc. All rights reserved. University of Alberta, NutriTek/Starch trial Transition cow study -28 to 42 d relative to calving Total of 120 cows (n = 30 per treatment) Main effects NutriTek vs. Control Starch level 1–21 DIM: High starch (26.7 %) vs. Low starch (21.4%) 22–42 DIM: High starch diet for all cows Key findings Greater feed intake (Fresh period) Improved feed efficiency (Week 4-6) Reduced post calving inflammation
- 24. © Diamond V, Inc. All rights reserved. DMI (kg/d) around the calving 27
- 25. © Diamond V, Inc. All rights reserved.28 Acidosis Index (Alberta) Control vs. NutriTek on high starch diets 0 2 4 6 8 10 12 14 16 18 20 1 2 3 4 5 6 7 9 13 16 20 23 Control-HS NutriTek-HS Days relative to calving
- 26. © Diamond V, Inc. All rights reserved. Much higher blood glucose on d42 29
- 27. © Diamond V, Inc. All rights reserved. K-State Update Transition cow study -28 to 42 d relative to calving Total of 60 cows (n = 30 per treatment) Control vs. NutriTek Key findings Favorable feeding behavior Greater milk fat during post-transition period Greater incidence of ketosis?
- 28. © Diamond V, Inc. All rights reserved. Feeding Behavior - Prepartum (KSU)
- 29. © Diamond V, Inc. All rights reserved. Feeding Behavior - Postpartum (KSU)
- 30. © Diamond V, Inc. All rights reserved. Dairy and beef meta-analyses Enhanced rumen stability Improved milk fat and NDF digestibility Strengthened innate immunity Reduced incidence and severity of mastitis and respiratory disease Increased IOFC ~ $0.47 per head per day in early lact. Update on Diamond V Ruminant Research
- 31. © Diamond V, Inc. All rights reserved. Colds and Flu Symptoms – Diamond V Epicor • 26% reduction in total days with symptoms Moyad et al (2008); Urologic Nursing 28: 50-55 Moyad et al (2010); Journal of Alternative and Complementary Medicine 16: 2013-2018
- 32. © Diamond V, Inc. All rights reserved. Enhanced innate immunity in calves on the DV calf program 101.5 102.5 103.5 104.5 0 5 10 15 20 25 RectalTemperature(°F) Days Post-infection Control Calf Program P < 0.05 Brewer et al., 2014 Fever
- 33. © Diamond V, Inc. All rights reserved. This presentation is the confidential and proprietary property of Diamond V. Diamond V does not give its consent for its distribution or license the use of its content. Part 1 – Montana Origin A Retrospective Study Evaluating the Effects of NaturSafe® on Overall Health and Economics of All-Natural Feedlot Cattle
- 34. © Diamond V, Inc. All rights reserved. NaturSafe Effects On Health Of All-Natural Feedlot Cattle – Montana Origin Control NaturSafe RRR or RRI1 95% CI of RRR or RRI P-Value NNT2 # Head 2594 1726 # Lots 5 4 Average In-weight (lb) 861 878 Average Days on Feed 166 176 1st Pulls, % 7.2 2.9 0.60 0.45 to 0.70 <0.01 23.4 2nd Pulls, % 2.4 1.1 0.53 0.22 to 0.72 <0.01 80.0 3+ Pulls, % 1.0 0.6 0.30 -0.40 to 0.65 0.31 361.4 Fallouts, % of all Cattle 6.2 0.9 0.85 0.75 to 0.91 <0.01 19.1 Fallouts, % of 1st Pulls 86.0 32.0 0.63 0.44 to 0.75 <0.01 1.9 Railers, % 0.1 0.5 -1.99 -8.92 to 0.10 0.07 -325.6 Mortality, % 0.5 0.2 0.50 -0.55 to 0.84 0.23 433.21.Relative Risk Reduction/Increase (RRR/RRI) represents the reduced (or increased) risk of an event occurring versus Control. A negative value indicates a relative risk increase (Ex. RRR of 0.40 = 40% reduced risk.). 2.NNT (Number Needed to Treat) represents the number of animals that would need to be fed NaturSafe in order to increase/decrease case number by one animal. A negative value represents number needed to harm. Field Trial Report BF031. 2017 37
- 35. © Diamond V, Inc. All rights reserved. NaturSafe Effects On Health Of All-Natural Feedlot Cattle – N. Dakota Origin Control NaturSafe RRR or RRI1 95% CI of RRR or RRI P-Value NNT2 # Head 770 749 # Lots 5 5 Average In-weight (lb) 774 887 Average Days on Feed 207 235 1st Pulls, % 24.2 14.4 0.40 0.26 to 0.52 <0.01 10.3 2nd Pulls, % 11.4 4.0 0.65 0.48 to 0.77 <0.01 13.5 3+ Pulls, % 6.5 2.5 0.61 0.34 to 0.77 <0.01 25.3 Fallouts, % of all Cattle 12.7 4.5 0.64 0.48 to 0.75 <0.01 12.2 Fallouts, % of 1st Pulls 52.7 31.5 0.40 0.19 to 0.56 <0.01 4.7 Railers, % 1.3 0.4 0.81 0.16 to 0.96 0.03 86.1 Mortality, % 3.8 0.9 0.75 0.44 to 0.89 <0.01 35.3 1.Relative Risk Reduction/Increase (RRR/RRI) represents the reduced (or increased) risk of an event occurring versus Control. A negative value indicates a relative risk increase (Ex. RRR of 0.40 = 40% reduced risk.). 2.NNT (Number Needed to Treat) represents the number of animals that would need to be fed NaturSafe in order to increase/decrease case number by one animal. A negative value represents number needed to harm. Field Trial Report BF032. 2017 38
- 36. © Diamond V, Inc. All rights reserved. NaturSafe Effects On Health Of All-Natural Feedlot Cattle – Mixed Origin Control NaturSafe RRR or RRI1 95% CI of RRR or RRI P-Value NNT2 # Head 1393 1562 # Lots 9 11 Average In-weight (lb) 845 881 Average Days on feed 160 190 1st Pulls, % 16.0 12.3 0.23 0.08 to 0.36 <0.01 26.9 2nd Pulls, % 6.4 4.3 0.33 0.09 to 0.51 0.01 47.6 3+ Pulls, % 3.8 2.5 0.34 0.01 to 0.56 0.04 76.5 Fallouts, % of All Cattle 11.1 4.8 0.57 0.44 to 0.67 <0.01 15.3 Fallouts, % of 1st Pulls 69.5 39.0 0.44 0.32 to 0.54 <0.01 3.3 Railers, % 0.7 1.1 -0.68 -2.77 to 0.25 0.20 226.1 Mortality, % 0.9 1.1 -0.17 -1.39 to 0.43 0.67 644.7 1.Relative Risk Reduction/Increase (RRR/RRI) represents the reduced (or increased) risk of an event occurring versus Control. A negative value indicates a relative risk increase (Ex. RRR of 0.40 = 40% reduced risk.). 2.NNT (Number Needed to Treat) represents the number of animals that would need to be fed NaturSafe in order to increase/decrease case number by one animal. A negative value represents number needed to harm. Field Trial Report BF033. 2017 39
- 37. © Diamond V, Inc. All rights reserved. NaturSafe is Field Proven 40 “In the Fall of 2015, every calf was mass medicated on arrival. During the same time period in 2016 while feeding NaturSafe, we totally eliminated all mass medication, and our health still improved.” Joe Klute Phelps County Feedyard, NE
- 38. © Diamond V, Inc. All rights reserved. SCC reduction following NutriTek 41 NT Started
- 39. © Diamond V, Inc. All rights reserved. Evaluate mastitis incidence and Linear Score on herds with minimum 12 months of feeding NT, 25 herds. Data evaluated the same # days pre/post implementation Herds ranged from 880 to 10,727 adult cows and milk production ranged from 7,800 to 12,700 kg on 305d bases 1.4 million production records analyzed 702,449 pre-implementation 742,000 post-implementation Using an Epidemiologic Approach to Evaluate the Effects on NutriTek on Mastitis 42
- 40. © Diamond V, Inc. All rights reserved.43 0% 10% 20% 30% 40% 50% 60% 70% Improvement Worse No Change Expected Biology would predict….
- 41. © Diamond V, Inc. All rights reserved. What we observed…. 44 0% 10% 20% 30% 40% 50% 60% 70% Improvement Worse No Change Expected NutriTek
- 42. Efficacy of supplementing NutriTek® to lactating cows on performance, immunometabolism, and health in response to an intramammary Streptococcus uberis challenge
- 43. © Diamond V, Inc. All rights reserved. Streptococcus uberis challenge on SCC Loor, preliminary report
- 44. © Diamond V, Inc. All rights reserved.
- 45. © Diamond V, Inc. All rights reserved. Dairy and beef meta-analyses Enhanced rumen stability Improved milk fat and NDF digestibility Strengthened innate immunity Reduced incidence and severity of mastitis and respiratory disease Increased IOFC ~ $0.47 per head per day in early lact. Update on Diamond V Ruminant Research
- 46. © Diamond V, Inc. All rights reserved.49 Summary from 2018 NutriTek Transition Cow Studies Economic Summary from the 2018 NutriTek Transition Studies Olagaray, et al., 2018; 1 wk to 6 wk post-partum; Control vs 19g NutriTek; 19.4% Startch; N=30 cows/tmt; Completely Randomized Design (CRD) Control NutriTek Diff Milk, lbs. 91.1 88.6 -2.5 Fat, % 3.96 4.32 0.36 SCC, cells/ml 169,730 115,344 -54,386 Fat-Corrected Milk (FCM), lbs. (3.5% FCM basis) 96.7 101.2 4.5 Dry Matter Intake (DMI), lbs. 45.3 45.6 0.2 FCM/DMI 2.12 2.21 4.2% Shi et al., 2018 (21.4% starch wk 1-3, then 26.7% starch wk 4-6); N=30 cows/tmt; CRD Control NutriTek Diff Milk, lbs. 84.8 83.5 -1.3 Fat, % 3.87 4.15 0.28 SCC, cells/ml 53,100 87,400 34,300 Fat-Corrected Milk (FCM), lbs. (3.5% FCM basis) 92.7 96.7 4.0 Dry Matter Intake (DMI), lbs. 40.7 41.0 0.2 FCM/DMI 2.28 2.36 3.7% Shi et al., 2018 (26.7% starch wk 1-6); N=30 cows/tmt; CRD Control NutriTek Diff Milk, lbs. 77.8 81.7 4.0 Fat, % 4.24 4.10 -0.14 SCC, cells/ml 170,000 69,800 -100,200 Fat-Corrected Milk (FCM), lbs. (3.5% FCM basis) 91.9 93.8 2.0 Dry Matter Intake (DMI), lbs. 40.7 40.1 -0.7 FCM/DMI 2.25 2.34 3.8%
- 47. © Diamond V, Inc. All rights reserved. Economics Summary from 2018 NutriTek Transition Cow Studies 50 Fat-Corrected Milk was used instead of Energy-Corrected milk because both Universities reported FCM and only KSU reported ECM (U of Albert reported Solids- Corrected Milk). SCC bonus varies throughout the U.S. 10 cents per cwt is a very conservative estimate based on normal bonus incentives (i.e., below 200,000 or below 100,000) Overall Average (2 Studies; 3 comparisons) Control NutriTek Diff Milk, lbs. 84.5 84.6 0.1 Fat, % 4.02 4.19 0.17 SCC, cells/ml 130,943 90,848 -40,095 Fat-Corrected Milk (FCM), lbs. (3.5% FCM basis) 93.8 97.2 3.5 Dry Matter Intake (DMI), lbs. 42.3 42.2 -0.1 FCM/DMI 2.22 2.30 3.9% Economics Control NutriTek Diff Fat-Corrected Milk revenue, $/cow/d (FCM @ $14.50/cwt.) $13.595 $14.099 $0.50 DMI, cost (@ $0.12/lbs. DM) -$5.073 -$5.065 $0.01 SCC bonus ( < 100,000 = $0.10/100 lbs. milk) $0.00 $0.08 $0.08 Cost of NutriTek ($0.13/hd/d) $0.00 ($0.13) ($0.13) IOFC (Milk revenue - Feed costs) $8.522 $8.988 $0.47 Annualized IOFC for 1,000 cow Dairy, $/year $170,124
- 48. © Diamond V, Inc. All rights reserved.51 100,000+ cows on 30+ dairies Response will vary dependent on the cow and her individual needs $0.37 average increase in income over feed costs
- 49. © Diamond V, Inc. All rights reserved. Improvements in ruminal stability Enhanced innate immunity These effects, along with positive changes in the rumen microbiome, lead to improvements in performance Summary of Diamond V Research 52
- 50. © Diamond V, Inc. All rights reserved. All label claims must meet the laws and regulations of each state or country where the product will be used. This presentation and the information described are not label claims or intended to imply that Diamond V products can be used to diagnose, mitigate, treat, cure, or prevent disease.