Four primary care practices were identified as "medical home runs" because their patients had 15-20% lower total annual health care costs compared to other practices in their regions, without compromising quality of care. The practices achieved this through three common features: 1) Exceptional individualized care for chronic conditions, including 24/7 support and coordination with specialists. 2) Efficient service provision. 3) Careful selection and coordination with medical specialists. If these practices' approaches were more widely adopted, the authors argue it could enable universal health coverage in the US without increasing overall spending or reducing quality.