Aminoglycosides Pharmacology

This document discusses the pharmacology of aminoglycoside antibiotics. It begins by describing their chemical structure and origins from soil actinomycetes. It then classifies them into systemic and topical groups and describes their mechanism of action as involving bacterial cell membrane transport and binding to bacterial ribosomes to inhibit protein synthesis. The document discusses mechanisms of resistance, toxicities including ototoxicity and nephrotoxicity, precautions, pharmacokinetics, and individual drug profiles for gentamicin, streptomycin, and kanamycin.