Wes McKinney gives an overview of the current data analysis tools landscape in Python and R. He discusses essential Python packages like NumPy, pandas, and scikit-learn. For R, he covers packages in the "Hadley stack" like dplyr and ggplot2. IPython/Jupyter notebooks are also mentioned as a platform for interactive data analysis across languages. The talk aims to highlight trends, opportunities, and challenges in the open source data science tool ecosystem.