Anti -depressants: classification & mechanism of action
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The document provides an overview of various classifications of antidepressants, including reversible MAO-A inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and atypical antidepressants. It details their mechanisms of action, highlighting how some enhance neurotransmission while others influence receptor activity. Additionally, it discusses the role of bupropion and mirtazapine in managing cravings and improving neurotransmission.
Anti -depressants: classification & mechanism of action
- 1. Antidepressants Dr. Kanishk Deep Sharma Intern J.N. Medical College, Belagavi
- 3. 1. Reversible inhibitors of MAO-A • Moclobemide, Clorgyline 1. Tricyclic antidepressants 1. NA + 5-HT reuptake inhibitors • Imipramine, Trimipramine, Amitriptyline 1. Predominantly NA reuptake inhibitors • Reboxetine, Desipramine, Nortriptyline 1. Selective serotonin reuptake inhibitors • Fluoxetine, Fluvoxamine, Paroxetine, Sertraline 1. Serotonin- Norepinephrine Reuptake Inhibitors • Duloxetine, Venlafaxine 1. 5-HT2 Antagonist • Nefazodone, Trazodone 1. Atypical antidepressants 1.Mirtazapine, Bupropion
- 4. SSRIs & TCA
- 7. SNRIs
- 13. • weak inhibitors of serotonin reuptake • block postsynaptic 5-HT2A receptors • chronic use:- desensitize 5-HT1A presynaptic autoreceptors and, thereby, increase serotonin release
- 15. Bupropion • weak dopamine and nor-epinephrine reuptake inhibitor • assists in decreasing the craving and attenuating the withdrawal symptoms for nicotine in tobacco users
- 16. Mirtazapine • enhances serotonin and nor-epinephrine neurotransmission • Block pre-synaptic alpha-2 receptors • Block 5-HT2 receptors