This document provides 6 rules for building powerful web applications on AWS: 1) Service all web requests, 2) Service requests as fast as possible, 3) Handle requests at any scale, 4) Simplify architecture with services, 5) Automate operational management, and 6) Leverage unique cloud properties. It describes AWS services like Route53, ELB, RDS, DynamoDB, SQS, CloudSearch, and EMR that can be used to implement these rules and build scalable, high-performance applications on AWS. Customer examples are provided that demonstrate how AWS services allow them to focus on their business rather than infrastructure management.