The document assesses the economic impacts of Porcine Reproductive and Respiratory Syndrome (PRRS) on the swine industry, highlighting production losses such as reduced feed efficiency, increased mortality, and reproductive inefficiency. It presents case studies that indicate significant financial losses per litter and per pig during various production phases, totaling an annual economic cost for the U.S. swine industry of approximately $594 to $687 million. Additionally, it discusses the importance of biosecurity measures and the trade-offs between prevention and treatment strategies.