asthma medical treatment
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The document discusses various medications for asthma and allergic conditions, including mast cell stabilizers (sodium cromoglycate, ketotifen), leukotriene antagonists (montelukast, zafirlukast, zileuton), and corticosteroids (prednisolone, budesonide). Each medication's mechanism, usage indications, and potential adverse effects are detailed, highlighting the role of corticosteroids in severe cases and the alternative use of leukotriene antagonists. The document emphasizes the importance of inhaled steroids as a primary therapy for asthma and outlines their dosage and side effects.
asthma medical treatment
- 1. MAST CELL STABILIZERS BY Mr. Kanishk Deep Sharma LEUKOTRIENE ANTAGONISTS CORTICOSTEROIDS
- 3. THEY ARE CHROMONE DERIVATIVES THAT BLOCK CHLORIDE CHANNELS ESSENTIAL FOR MAST CELL DEGRANULATION WHICH INTURN STABILIZE THE MAST CELL -PREVENTING HISTAMINE RELEASE & RELATED MEDIATORS
- 8. KETOTIFEN ANTIHISTAMINIC WITH CROMOGLYCOL ATE LIKE ACTION NOT A BRONCHO DILATOR PRODUCES SEDATION SYMPTOMATIC RELIEF IN 1.ATOPIC DERMATITIS 2.PERENNIAL RHINITIS 3.CONJUNCTIVITIS 4.URTICARIA 5.FOOD ALLERGY ABSORBED ORALLYBIOAVAILIBILITY: 50% T1/2 : 22HOURS
- 11. LEUKOTRIENES FATTY COMPOUNDS PRODUCED BY IMMUNE SYSTEM THAT CAUSE INFLAMMATION IN ASTHMA & BRONCHITIS , & CONSTRICTS AIRWAYS
- 14. • BROCHODILATATION • REDUCED SPUTUM EOSINOPHIL COUNT • SUPPRESION OF BRONCHIAL INFLAMMATION • MILD TO MODERATE ASTHAMA: ALTERNATIVE TO INHALED GLUCOCORTICOIDS • SEVERE ASTHMA: PERMIT STEROID DOSE REDUCTION & RESCUE B2 AGONIST INHALATION
- 15. • WELL ABSORBED ORALLY • HIGHLY PLASMA PROTEIN BOUND • PLASMA T1/2 : 3-6HOURS(MONTELUKAST) • PLASMA T1/2 : 8-12 HOURS(ZAFIRLUKAST)
- 17. ZILEUTON 5-LOX INHIBITOR BLOCKS LTC4/D4/B4 SYNTHESIS CLINICAL EFFICACY SIMILAR TO MONTELUKAST SHORT ACTION HEPATOTOXIC POTENTIAL RESTRICTED USE
- 19. • GLUCOCORTICOIDS ARE STEROID HORMONES • ANTI-INFLAMMATORY • PREVENT PHOSPHOLIPID RELEASE • DECREASE EOSINOPHIL ACTION
- 20. TYPE OF THERAPY SYSTEMIC STEROID THERAPY INHALED STEROIDS PREDNISOLONE BUDESONIDE BECLOMETHASONE DIPRPIONATE
- 21. SYSTEMIC STEROIDS O USED IN 2 SITUATIONS 1. SEVERE CHRONIC ASTHMA 2. STATUS ASTHAMATICUS
- 22. 1. SEVERE CHRONIC ASTHMA WHEN NOT CONTROLLED BY BROCHODILATORS/INHALED STEROIDS START PREDNISOLONE 20-60Mg/DAY 2. STATUS ASTHMATICUS HIGH DOSE I.V. GLUCOCORTICOID, ACT IN 6-24 HRS
- 23. INHALED STEROIDS O HIGH TOPICAL LOW SYSTEMIC ACTIVITY O SHOULD BE ‘STEP 1’ FOR ALL ASTHMA PATIENTS O INDICATED WHEN B2 AGONIST REQUIRED DAILY O START 100-200 mg BD
- 24. EFFECT O SUPRESS BRONCHIAL INFLAMMATION O INCREASE PEAK EXPIRATORY FLOW RATE O NO ROLE IN ACUTE ATTACK O PEAK EFFECT IN 4-7 DAYS O DOESN’T PRECIPITATE ASTHMA, MUUSCULAR PAIN, LASSITUDE, DEPRESSION, HYPOTENSION
- 25. IN COPD O HIGH DOSE INHALED STEROIDS BENEFICIAL ONLY IN ADVANCED CASES O NO PROOF THAT THEY SLOW DISEASE PROGRESSION
- 26. ADVERSE EFFECT HOARSENESS OF VOICE SYMPTOMATIC OROPHARYNGEAL CANDIDIASIS SYSTEMC EFFECT AT >600 mg DOSE/DAY • MOOD CHANGES • OSTEOPOROSIS • BRUISING • PETECHIAE • PITUITARY-ADRENAL SUPPRESION DYSPHONIA
- 27. EXAMPLES OBUDESONIDE OBECLOMETHASONE DIPRPIONATE OFLUTICASONE PROPIONATE OFLUNISOLIDE OCICLESONIDE
- 28. THANK YOU