Babesiosis in Canine and Feline and Bovine patients .pptx

Babesiosis in Canine and Feline and Bovine patients .pptx

• 1.
  Babesiosis Dr. PallavShekhar Faculty Department of Veterinary Medicine
• 2.
  Introduction • Babesiosis istick transmitted haemoprotozoan infection of cattle, buffalo, horse, sheep, goat, dog, pig and wild animals characterized by fever, anaemia, haemoglobinaemia and haemoglobinuria. • The Babesia is divided into two groups  Large form: 2.5 to 5 𝜇 long  Small form: Less than 2.5 𝜇 long
• 3.
  Shape and angle •Pyriform(Pear Shaped) rounded • Oval or bizarre in structure • The angle between the two parasite in large form is acute and in small form is obtuse.
• 4.
  Host and Babesia species Animal Speciesinvolved Cattle, buffalo Horse Sheep Pig Dog Cat Babesia bigemina; Babesia bovis; Babesia divergens; Babesia major. Babesia equi; Babesia caballi. Babesia motasi; Babesia ovis. Babesia trautmanni. Babesia canis; Babesia gibsoni. Babesia felis.
• 5.
  Epidemiology • Babesia parasitehas been placed on record for the first time by Babes in 1888 from blood from African cattle. • Babesia is present world wide. • Diseases has been reported in all breeds of cattle but crossbred are more commonly affected. • Young age cattle are highly susceptible. • Babesia infection is reported in Buffaloes • Babesiosis is reported from 2 days to 1month old calves.
• 6.
  Mode of Transmission •The disease is transmitted under natural conditions from affected to healthy animals through ticks. • Boophilus microplus and B. annulatus are the major vectors of bovine babesiosis in India. • In horse, Dermacentor, Hyalomma and Rhipicephalus are responsible for transmission of both Babesia spp. • Babesiosis is also transmitted by Rhipicephalus, Haemaphysalis, Dermacentor and Ixodes ticks. • Canine babesiosis is transmitted by the ticks of the genera Rhipicephalus, Dermacentor, Hyalomma and Haemaphysalis. • In general, the disease is transmitted transovarially or trans-stadially.
• 7.
  Pathogenesis • Babesia –RBC- Intravascular haemolysis • Proteolytic enzymes- infected erythrocytes - increased erythrocytic fragility- hypotensive shock - disseminated intravascular coagulation • Coating of R.B.C. by parasitic antigen- autoagglutination of R.B.C. • Parasitaemia, fever and haemoglobinuria are the main clinical attributes. • Death occurs due to anaemic anoxia.
• 8.
  Clinical Signs • Highfever • Anorexia, • Depression • Weakness. • Severe jaundice and haemoglobinuria. • Marked anaemia
• 9.
  • In dog,five forms of the disease may be encountered.  Alimentary form - Characterized by stomatitis, gastritis and enteritis.  Respiratory form - Characterized by respiratory distress (dyspnoea).  Circulatory form - Characterized by oedema.  Ocular form - Characterized by keratitis and iritis.  Muscular form - Characterized by muscle weakness. • Atypical signs like convulsion, locomotor disturbance, ascites, dyspnoea, cough, enlarged tonsils and bleeding from nostril.
• 10.
  • Disease hasalso been classified as (a) complicated from and (b) uncomplicated form (a) Complicated from in dog. This results due to haemolytic process. Complications comprise of acute renal failure, cerebral signs, coagulopathy, icterus, hepatopathy, immune mediated haemolytic anaemia, acute respiratory distress, haemoconcentration, hypotension, cardiac involvement and pancreatitis. (b) Uncomplicated form in dog. Acute haemolysis, fever, anorexia, depression pale mucous membrane, splenomegaly and water hammer pulse. This from may exist mild, moderate and severe depending on the severity. • In horses, haemoglobinuria is rare in occurrence and jaundice is more common, hence it is known as “biliary fever” .
• 11.
  Diagnosis Haematology (i) There issevere anaemia. (ii)There is increased leucocyte count associated with moderate neutrophilia. (iii)There is presence of albumin and bile pigment in the urine (iv)There is increased level of SGPT, BUN and Creatinine • Blood smear examination • ELISA • PCR
• 12.
  By Alan RWalker - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php? curid=19032008
• 13.
  Treatment • B. canis,B. rossi, and B. vogeli are most successfully treated with Diminazene aceturate (3.5 mg/kg subcutaneously or intramuscularly) or Imidocarb dipropionate Dog ( 3-6.6 mg/kg twice, 14 days apart, SC) Babesia bigemina in Cattle  Imidocarb (1mg/kg body weight)
• 14.
  • Treatment • B.bigemina and B. major (large species) are more sensitive to drug and require low doses. (a)B. gibsoni can be treated with atovagnone @ 13 mg/kg orally and azithromycin @ 10 mg 1 kg orally for 10 days (Lobetti 2004).
• 15.
  For B. gibsoni infection •B. gibsoni, diminazene aceturate often fails to eliminate parasites. Attempts to sterilize infections using triple antibiotic combinations: doxycycline (5 mg/kg, orally, twice daily), clindamycin (25 mg/kg, orally, twice daily), metronidazole (15 mg/kg, orally, twice daily) • doxycycline (7–10 mg/kg, orally, twice daily), enrofloxacin (2–2.5 mg/kg, orally, twice daily), metronidazole (5–15 mg/kg, orally, twice daily) i