The BP Texas City Refinery disaster was caused by human errors during the start-up of an isomerization unit. Contract workers were killed when a vapor cloud ignited after liquid erupted from an overfilled blow-down drum. Key failures included trailers being located too close to hazardous equipment, poor communication during shift changes, ignoring safety procedures during start-up, and faulty equipment that had not been properly maintained or repaired. The disaster could have been prevented through improved design of monitoring and alarm systems, enforcement of safety protocols, evacuation of non-essential personnel, and a stronger culture of process safety within the management and organization.