OÄ-½®Ä› ò›ÙÝ®ÊÄ 
Ê¥ ã«› SçÖÖ½›Ã›Äã: 
www. promoboz.com 
G›Ê¦ÙƒÖ«®‘ƒ½ ‘Êò›Ùƒ¦›: 
Ukraine, Russia, other CIS 
countries. Available 
by subscripƟ on, distribuƟ on 
to qualifi ed professionals, 
direct mailing, at specialized 
events – exhibiƟ ons, conferences, 
seminars, and symposiums. 
W› ƒÙ› Û—®ƒ ÖƒÙãě٠
Ê¥ ÝÖ›‘®ƒ½®þ›— óÊÙ½—ó®—› 
›ø«®®ã®ÊÄÝ ƒÄ— ›ò›ÄãÝ: 
ACHEMA, CPhI, interpack, 
P-MEC, Pharmtech, Pharmintech, 
Powtech, AnalyƟ ca, 
Adam Smith pharmaceuƟ cal 
conferences. 
CÊÄパãÝ: 
+380(44) 390 44 17; 
+380(44) 390 32 80; 
offi ce@promoboz.com 
galina@promoboz.com 
advert@promoboz.com 
+380(50) 29 249 15; 
Valentyn.Mohylyuk@gmail.com 
P h a r m a i n g r e d i e n t s 
SçÖÖ½›Ã›Äã Ê¥ “P«ƒÙÑ›ç㮑ƒ½ IÄ—çÝãÙù R›ò®›ó” Mƒ¦ƒþ®Ä› 
The Supplement contains up to date information about Excipients and APIs. Actual 
technologies of dosage forms development and manufacturing are covered as well. 
Articles included in the Supplement are provided by representatives of leading 
companies and reputable opinion leaders with a focus on professional experience 
and practical applications. The Supplement is intended to be a guide for selecting 
applicable solution for practical tasks, i.e. choosing: right ingredient for formulations, 
adequate approach for formulation development or production technology. 
T«› SçÖÖ½›Ã›Äã «›ƒ—½®Ä›Ý: 
• Current events 
• Company profi le 
• Excipients for direct compression (DC) and capsulaƟ on 
• Excipients for wet granulaƟ on (WG) 
• Solving challenges in the fi eld of solid dosage form formulaƟ on with the help of 
excipients 
• FuncƟ onal coaƟ ngs and encapsulaƟ on methods 
• Bioavailability enhancement or formulaƟ ons with poor-soluble API 
• Ingredients and technologies for liquid dosage forms 
• Ingredients and technologies for semi-solid dosage forms 
• Focus on API 
• Drug delivery systems (DDS). 
TƒÙ¦›ã ƒç—®›Ä‘›: 
Personnel involved in: 
• R & D and enhancement of products and technologies, 
• IntroducƟ on of new products and technologies, 
• Searching for new ideas, 
• Quality control and assurance of products and technological processes, …. 
Personnel of manufacturing plants, research organizaƟ ons, and laboratories involved 
in the development and improvement of products and technologies. Students 
of pharmaceuƟ cal and related departments. 
E—®ãÊÙ®ƒ½ Bʃٗ Ê¥ ã«› Mƒ¦ƒþ®Ä› 
P«ƒÙÑ›ç㮑ƒ½ IÄ—çÝãÙù R›ò®›ó 
Ингредиенты 
для фармации 
source of quality applicable knowledge
ˁ˱˟˻˚́˱˶˳˪ 
˚ ̃ˬ˟˪˵˲˯ˮˮ˯˥ ˚˟˲˳ˤˤ: 
www. promoboz.com 
ˀ˘˳˱˲˯˳˵˲˘ˮ˟ˮˤ˟ ˢ˶˲ˮ˘ˬ˘: 
˄к̛̬̦̌̌, ˀо̛̭̭́, д̬у̛̐е ̭т̬̦̼̌ 
ˁНʧ. Жу̬̦̌л до̭т̌̏л́ет̭́ 
к̏̌л̴̶̛̛̛̬о̦̦̼̥̏̌ 
п̬о̴е̛̭̭о̦̌л̥̌ от̬̭̌л̛, 
до̭тупе̦ по подп̛̭ке ̛ п̬̥́о̜ 
̬̭̭̼̌лке, ̬̭̌п̬о̭т̬̦̌́ет̭́ 
̦̌ ̭пе̶̛̌л̛̛̬̚о̵̦̦̼̏̌ 
̥е̬оп̛̬́т̵̛́ – ̼̭̏т̌̏к̵̌, 
ко̴̦е̬е̶̵̛̦́, ̭е̵̛̥̦̬̌̌, 
̛̭̥по̛̚у̵̥̌ ̛ т. д. 
М˟˞ˤ˘-˱˘˲˵ˮ˟˲ 
˚˟˞˶˿ˤ˺ ˱˲˯˹ˤˬ̂ˮ́˺ 
˭ˤ˲˯˚́˺ ˚́˳˵˘˚˯˪ − 
Аchema, CPhI, interpack, 
P-MEC, «Ф̬̥̌те̵», Pharmintech, 
Powtech, AnalyƟ ca, 
«А̦̌л̛т̛к̌-Эк̭по», 
̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̥е̬оп̛̬́т̛̜ 
̛̦̭т̛тут̌ Ад̥̌̌ ˁ̛̥т̌ 
К˯ˮ˵˘˪˵ˮ́˟ ˞˘ˮˮ́˟: 
+380(44) 390 44 17; 
+380(44) 390 32 80; 
offi ce@promoboz.com 
galina@promoboz.com 
advert@promoboz.com 
+380(50) 29 249 15; 
Valentyn.Mohylyuk@gmail.com 
P h a r m a i n g r e d i e n t s 
ˁ˱˟˻˚́˱˶˳˪ ˢ˶˲ˮ˘ˬ˘ «Ф˘˲˭˘˻˟˚˵ˤ˽˟˳˪˘̆ ˯˵˲˘˳ˬ̂», 
̏ кото̬о̥ п̬ед̭т̌̏ле̦̌ ̌кту̌л̦̽̌́ ̴̛̦о̶̛̬̥̌́ о ̭̏по̥о̐̌тел̵̦̼̽ ̏е̺е̭т̵̏̌ 
̛ ̌кт̵̛̦̼̏ ̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̛̦̬̐ед̛е̦т̵̌ (АФИ), ̌ т̌к̙е п̛̬̏еде̦̼ ̭̏е- 
де̛̦́ о ̭о̬̏е̥е̵̦̦̼ те̵̦оло̵̛̐́ ̬̬̌̌̍̚отк̛ ̛ п̬о̛̏̚од̭т̏̌ лек̬̭̌т̏е̵̦̦̼ 
̴о̬̥ (ЛФ). ˁпе̶̼̏пу̭к ̭оде̛̬̙т ̭о̬̏е̥е̦̦у̀ ̼̭̏окок̸̌е̭т̏е̦̦у̀ п̬о̴е̭- 
̛̭о̦̌л̦̽у̀ ̴̛̦о̶̛̬̥̌̀ от ̏еду̵̛̺ ко̥п̛̦̜̌ ̛ п̵̛̬̦̦̦̼̌̚ л̛де̬о̏ ̴̬̥̌̌- 
̶е̏т̸̛е̭ко̐о ̬̼̦к̌, кото̬у̀ ̥о̙̦о ̛̭пол̽̚о̏̌т̽ ̏ п̬̌кт̸̛е̭ко̜ де́тел̦̽о̭т̛. 
И̚д̛̦̌е п̛̬̦̏̌̚о ̭лу̛̙т̽ ̬уко̏од̭т̏о̥ к ̼̏̍о̬у п̬̌кт̸̛е̭к̛ п̛̬̥е̵̛̦̥̼ 
̬е̹е̛̦̜, ̭оот̏ет̭т̏у̵̛̺̀ под̵одо̏ к ̬̬̌̌̍̚отке, ̌ т̌к̙е ̛̦̬̐ед̛е̦то̏ дл́ ̬е- 
̶епту̬ ̛ те̵̦оло̛̜̐ п̬о̛̏̚од̭т̏̌. 
ˀ˶˙˲ˤ˪ˤ ˢ˶˲ˮ˘ˬ˘: 
• ˁо̼̍т̛́ ̛ ̦о̏о̭т̛ 
• ʿо̬т̬ет ко̥п̛̛̦̌ 
• ʦ̭по̥о̐̌тел̦̼̽е ̏е̺е̭т̏̌ дл́ п̬̥́о̐о п̬е̭̭о̛̦̏̌́ ̛ к̌п̭ул̛̬о̛̦̏̌́ 
• ʦ̭по̥о̐̌тел̦̼̽е ̏е̺е̭т̏̌ дл́ ̏л̙̦̌о̜ ̬̦̐̌ул̶̛̛́ 
• Э̴̴ект̛̦̏ое ̛̭пол̽̚о̛̦̏̌е ̭̏по̥о̐̌тел̵̦̼̽ ̏е̺е̭т̏ ̏ ̬е̶епту̵̬̌ 
т̏е̬д̵̼ ЛФ 
• Фу̦к̶̛о̦̌л̦̼̽е пок̬̼т̛́ ̛ ̥етод̼ ̛̦к̌п̭ул̶̛̛́ 
• ˀе̶епту̬̼ ̭ т̬уд̦о̬̭̌т̏о̛̛̬̥̼̥ ̭у̭̍т̶̛̛̦̥̌́, по̼̹̏е̛̦е 
̛̍одо̭туп̦о̭т̛ 
• И̦̬̐ед̛е̦т̼ ̛ те̵̦оло̛̛̐ дл́ ̛̙дк̵̛ ЛФ 
• И̦̬̐ед̛е̦т̼ ̛ те̵̦оло̛̛̐ дл́ ̥́̐к̵̛ ЛФ 
• Фоку̭ ̦̌ АФИ 
• ˁ̛̭те̥̼ до̭т̌̏к̛ АФИ. 
Ц˟ˬ˟˚˘̆ ˘˶˞ˤ˵˯˲ˤ̆: 
ʿе̬̭о̦̌л, ̏о̏ле̸е̦̦̼̜ ̏: 
• п̬о̶е̭̭ R & D, улу̸̹е̛̦́ ̛ у̭о̏е̬̹е̦̭т̏о̛̦̏̌́ п̬одукто̏ ̛ те̵̦оло̛̜̐; 
• ̦̏ед̬е̛̦е ̦о̵̼̏ п̬одукто̏ ̛ те̵̦оло̛̜̐; 
• по̛̭к ̦о̵̼̏ ̛де̜ ̛ путе̜ ̵̛ ̬е̌л̶̛̛̛̌̚; 
• ко̦т̬ол̽ ̛ о̍е̭пе̸е̛̦е к̸̌е̭т̏̌ п̬одук̶̛̛ ̛ те̵̦оло̸̛̐е̭к̵̛ п̬о̶е̭̭о̏. 
ˁот̬уд̛̦к̛ п̬о̛̏̚од̭т̏е̵̦̦̼ п̬едп̛̬́т̛̜, ̛̭̭ледо̏̌тел̭̽к̵̛ о̶̛̛̬̦̜̐̌̌̚, 
л̌̍о̬̌то̛̬̜, у̸̭̌т̏у̵̛̺̀ ̏ ̬̬̌̌̍̚отке ̛ у̭о̏е̬̹е̦̭т̏о̛̛̦̏̌ п̬одукто̏ 
̛ те̵̦оло̛̜̐. ˁтуде̦т̼ ̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̛ ̭̥е̵̙̦̼ ̴̌кул̽тето̏. 
ˀ˟˞˘˪˻ˤ̆ ˢ˶˲ˮ˘ˬ˘ 
«Ф˘˲˭˘˻˟˚˵ˤ˽˟˳˪˘̆ ˯˵˲˘˳ˬ̂» 
Ингредиенты 
для фармации 
источник качественных прикладных знаний
P h a r m a i n g r e d i e n t s 
Ингредиенты 
для фармации 
www.promoboz.com 
октябрь 
2014 
специальный выпуск ˃˟˭˘ ˮ˯˭˟˲˘: ʿ̬я̥ое п̬е̭̭ова̦ие 
источник качественных прикладных знаний

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ACUTE CALCULAR CHOLECYSTITIS: A CASE STUDY

Briefly about pharma ingredients (EN & RU)

  • 1. OÄ-½®Ä› ò›ÙÝ®ÊÄ Ê¥ ã«› SçÖÖ½›Ã›Äã: www. promoboz.com G›Ê¦ÙƒÖ«®‘ƒ½ ‘Êò›Ùƒ¦›: Ukraine, Russia, other CIS countries. Available by subscripƟ on, distribuƟ on to qualifi ed professionals, direct mailing, at specialized events – exhibiƟ ons, conferences, seminars, and symposiums. W› ƒÙ› Û—®ƒ ÖƒÙãě٠ʥ ÝÖ›‘®ƒ½®þ›— óÊÙ½—ó®—› ›ø«®®ã®ÊÄÝ ƒÄ— ›ò›ÄãÝ: ACHEMA, CPhI, interpack, P-MEC, Pharmtech, Pharmintech, Powtech, AnalyƟ ca, Adam Smith pharmaceuƟ cal conferences. CÊÄパãÝ: +380(44) 390 44 17; +380(44) 390 32 80; offi [email protected] [email protected] [email protected] +380(50) 29 249 15; [email protected] P h a r m a i n g r e d i e n t s SçÖÖ½›Ã›Äã Ê¥ “P«ƒÙÑ›ç㮑ƒ½ IÄ—çÝãÙù R›ò®›ó” Mƒ¦ƒþ®Ä› The Supplement contains up to date information about Excipients and APIs. Actual technologies of dosage forms development and manufacturing are covered as well. Articles included in the Supplement are provided by representatives of leading companies and reputable opinion leaders with a focus on professional experience and practical applications. The Supplement is intended to be a guide for selecting applicable solution for practical tasks, i.e. choosing: right ingredient for formulations, adequate approach for formulation development or production technology. T«› SçÖÖ½›Ã›Äã «›ƒ—½®Ä›Ý: • Current events • Company profi le • Excipients for direct compression (DC) and capsulaƟ on • Excipients for wet granulaƟ on (WG) • Solving challenges in the fi eld of solid dosage form formulaƟ on with the help of excipients • FuncƟ onal coaƟ ngs and encapsulaƟ on methods • Bioavailability enhancement or formulaƟ ons with poor-soluble API • Ingredients and technologies for liquid dosage forms • Ingredients and technologies for semi-solid dosage forms • Focus on API • Drug delivery systems (DDS). TƒÙ¦›ã ƒç—®›Ä‘›: Personnel involved in: • R & D and enhancement of products and technologies, • IntroducƟ on of new products and technologies, • Searching for new ideas, • Quality control and assurance of products and technological processes, …. Personnel of manufacturing plants, research organizaƟ ons, and laboratories involved in the development and improvement of products and technologies. Students of pharmaceuƟ cal and related departments. E—®ãÊÙ®ƒ½ Bʃٗ Ê¥ ã«› Mƒ¦ƒþ®Ä› P«ƒÙÑ›ç㮑ƒ½ IÄ—çÝãÙù R›ò®›ó Ингредиенты для фармации source of quality applicable knowledge
  • 2. ˁ˱˟˻˚́˱˶˳˪ ˚ ̃ˬ˟˪˵˲˯ˮˮ˯˥ ˚˟˲˳ˤˤ: www. promoboz.com ˀ˘˳˱˲˯˳˵˲˘ˮ˟ˮˤ˟ ˢ˶˲ˮ˘ˬ˘: ˄к̛̬̦̌̌, ˀо̛̭̭́, д̬у̛̐е ̭т̬̦̼̌ ˁНʧ. Жу̬̦̌л до̭т̌̏л́ет̭́ к̏̌л̴̶̛̛̛̬о̦̦̼̥̏̌ п̬о̴е̛̭̭о̦̌л̥̌ от̬̭̌л̛, до̭тупе̦ по подп̛̭ке ̛ п̬̥́о̜ ̬̭̭̼̌лке, ̬̭̌п̬о̭т̬̦̌́ет̭́ ̦̌ ̭пе̶̛̌л̛̛̬̚о̵̦̦̼̏̌ ̥е̬оп̛̬́т̵̛́ – ̼̭̏т̌̏к̵̌, ко̴̦е̬е̶̵̛̦́, ̭е̵̛̥̦̬̌̌, ̛̭̥по̛̚у̵̥̌ ̛ т. д. М˟˞ˤ˘-˱˘˲˵ˮ˟˲ ˚˟˞˶˿ˤ˺ ˱˲˯˹ˤˬ̂ˮ́˺ ˭ˤ˲˯˚́˺ ˚́˳˵˘˚˯˪ − Аchema, CPhI, interpack, P-MEC, «Ф̬̥̌те̵», Pharmintech, Powtech, AnalyƟ ca, «А̦̌л̛т̛к̌-Эк̭по», ̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̥е̬оп̛̬́т̛̜ ̛̦̭т̛тут̌ Ад̥̌̌ ˁ̛̥т̌ К˯ˮ˵˘˪˵ˮ́˟ ˞˘ˮˮ́˟: +380(44) 390 44 17; +380(44) 390 32 80; offi [email protected] [email protected] [email protected] +380(50) 29 249 15; [email protected] P h a r m a i n g r e d i e n t s ˁ˱˟˻˚́˱˶˳˪ ˢ˶˲ˮ˘ˬ˘ «Ф˘˲˭˘˻˟˚˵ˤ˽˟˳˪˘̆ ˯˵˲˘˳ˬ̂», ̏ кото̬о̥ п̬ед̭т̌̏ле̦̌ ̌кту̌л̦̽̌́ ̴̛̦о̶̛̬̥̌́ о ̭̏по̥о̐̌тел̵̦̼̽ ̏е̺е̭т̵̏̌ ̛ ̌кт̵̛̦̼̏ ̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̛̦̬̐ед̛е̦т̵̌ (АФИ), ̌ т̌к̙е п̛̬̏еде̦̼ ̭̏е- де̛̦́ о ̭о̬̏е̥е̵̦̦̼ те̵̦оло̵̛̐́ ̬̬̌̌̍̚отк̛ ̛ п̬о̛̏̚од̭т̏̌ лек̬̭̌т̏е̵̦̦̼ ̴о̬̥ (ЛФ). ˁпе̶̼̏пу̭к ̭оде̛̬̙т ̭о̬̏е̥е̦̦у̀ ̼̭̏окок̸̌е̭т̏е̦̦у̀ п̬о̴е̭- ̛̭о̦̌л̦̽у̀ ̴̛̦о̶̛̬̥̌̀ от ̏еду̵̛̺ ко̥п̛̦̜̌ ̛ п̵̛̬̦̦̦̼̌̚ л̛де̬о̏ ̴̬̥̌̌- ̶е̏т̸̛е̭ко̐о ̬̼̦к̌, кото̬у̀ ̥о̙̦о ̛̭пол̽̚о̏̌т̽ ̏ п̬̌кт̸̛е̭ко̜ де́тел̦̽о̭т̛. И̚д̛̦̌е п̛̬̦̏̌̚о ̭лу̛̙т̽ ̬уко̏од̭т̏о̥ к ̼̏̍о̬у п̬̌кт̸̛е̭к̛ п̛̬̥е̵̛̦̥̼ ̬е̹е̛̦̜, ̭оот̏ет̭т̏у̵̛̺̀ под̵одо̏ к ̬̬̌̌̍̚отке, ̌ т̌к̙е ̛̦̬̐ед̛е̦то̏ дл́ ̬е- ̶епту̬ ̛ те̵̦оло̛̜̐ п̬о̛̏̚од̭т̏̌. ˀ˶˙˲ˤ˪ˤ ˢ˶˲ˮ˘ˬ˘: • ˁо̼̍т̛́ ̛ ̦о̏о̭т̛ • ʿо̬т̬ет ко̥п̛̛̦̌ • ʦ̭по̥о̐̌тел̦̼̽е ̏е̺е̭т̏̌ дл́ п̬̥́о̐о п̬е̭̭о̛̦̏̌́ ̛ к̌п̭ул̛̬о̛̦̏̌́ • ʦ̭по̥о̐̌тел̦̼̽е ̏е̺е̭т̏̌ дл́ ̏л̙̦̌о̜ ̬̦̐̌ул̶̛̛́ • Э̴̴ект̛̦̏ое ̛̭пол̽̚о̛̦̏̌е ̭̏по̥о̐̌тел̵̦̼̽ ̏е̺е̭т̏ ̏ ̬е̶епту̵̬̌ т̏е̬д̵̼ ЛФ • Фу̦к̶̛о̦̌л̦̼̽е пок̬̼т̛́ ̛ ̥етод̼ ̛̦к̌п̭ул̶̛̛́ • ˀе̶епту̬̼ ̭ т̬уд̦о̬̭̌т̏о̛̛̬̥̼̥ ̭у̭̍т̶̛̛̦̥̌́, по̼̹̏е̛̦е ̛̍одо̭туп̦о̭т̛ • И̦̬̐ед̛е̦т̼ ̛ те̵̦оло̛̛̐ дл́ ̛̙дк̵̛ ЛФ • И̦̬̐ед̛е̦т̼ ̛ те̵̦оло̛̛̐ дл́ ̥́̐к̵̛ ЛФ • Фоку̭ ̦̌ АФИ • ˁ̛̭те̥̼ до̭т̌̏к̛ АФИ. Ц˟ˬ˟˚˘̆ ˘˶˞ˤ˵˯˲ˤ̆: ʿе̬̭о̦̌л, ̏о̏ле̸е̦̦̼̜ ̏: • п̬о̶е̭̭ R & D, улу̸̹е̛̦́ ̛ у̭о̏е̬̹е̦̭т̏о̛̦̏̌́ п̬одукто̏ ̛ те̵̦оло̛̜̐; • ̦̏ед̬е̛̦е ̦о̵̼̏ п̬одукто̏ ̛ те̵̦оло̛̜̐; • по̛̭к ̦о̵̼̏ ̛де̜ ̛ путе̜ ̵̛ ̬е̌л̶̛̛̛̌̚; • ко̦т̬ол̽ ̛ о̍е̭пе̸е̛̦е к̸̌е̭т̏̌ п̬одук̶̛̛ ̛ те̵̦оло̸̛̐е̭к̵̛ п̬о̶е̭̭о̏. ˁот̬уд̛̦к̛ п̬о̛̏̚од̭т̏е̵̦̦̼ п̬едп̛̬́т̛̜, ̛̭̭ледо̏̌тел̭̽к̵̛ о̶̛̛̬̦̜̐̌̌̚, л̌̍о̬̌то̛̬̜, у̸̭̌т̏у̵̛̺̀ ̏ ̬̬̌̌̍̚отке ̛ у̭о̏е̬̹е̦̭т̏о̛̛̦̏̌ п̬одукто̏ ̛ те̵̦оло̛̜̐. ˁтуде̦т̼ ̴̶̬̥̌̌е̏т̸̛е̭к̵̛ ̛ ̭̥е̵̙̦̼ ̴̌кул̽тето̏. ˀ˟˞˘˪˻ˤ̆ ˢ˶˲ˮ˘ˬ˘ «Ф˘˲˭˘˻˟˚˵ˤ˽˟˳˪˘̆ ˯˵˲˘˳ˬ̂» Ингредиенты для фармации источник качественных прикладных знаний
  • 3. P h a r m a i n g r e d i e n t s Ингредиенты для фармации www.promoboz.com октябрь 2014 специальный выпуск ˃˟˭˘ ˮ˯˭˟˲˘: ʿ̬я̥ое п̬е̭̭ова̦ие источник качественных прикладных знаний