clinical corelations of Muscle_Dystrophies & Myopathies

💡 Muscle Remodeling, Dystrophies, Myasthenia, and Clinical Disorders – Comprehensive Lecture by Dr. Faiza 💡 This lecture explains how skeletal muscle adapts to function through remodeling and how different diseases and physiological changes alter this function. It also covers major clinical disorders like muscular dystrophies, myasthenia gravis, and Lambert-Eaton syndrome, providing clear pathophysiological insights and treatment principles. 📌 Key Concepts Covered: Muscle Remodeling: Hypertrophy: Growth by increased myofilament synthesis Atrophy: Disuse, denervation, and sarcopenia Hyperplasia and length adjustment Electrophysiology basics (EMG) Neuromuscular Disorders: Duchenne and Becker Muscular Dystrophy Titin/Desmin-related myopathies McArdle’s syndrome and metabolic myopathies Rigor Mortis: Cause and timeline of postmortem rigidity Myasthenia Gravis (MG): Autoimmune destruction of ACh receptors Diagnosis: EMG, antibody tests, Tensilon Treatment: AChE inhibitors, immunosuppressants, thymectomy Lambert-Eaton Myasthenic Syndrome (LEMS): Presynaptic Ca²⁺ channel antibodies Association with small cell lung cancer Management and treatment options Muscle Fatigue and Contractures Heat Production in Muscles: Initial, resting, recovery, and shortening heat 🧠 Includes real-world cases and physiological logic to explain: Why muscle fibers atrophy with aging or immobilization Why MG symptoms worsen with effort but improve with rest How EMG helps detect subclinical nerve damage The role of calcium in both contraction and pathology 🎓 Who Should Watch This Lecture? 1st and 2nd year MBBS, DPT, and Allied Health students Medical educators and residents in neurology or rehabilitation Candidates preparing for FCPS-I, USMLE, PLAB, STEP 1, NEET PG Physical therapy, sports science, and orthopedics students Anyone interested in muscle physiology, pathology, and recovery 👩‍⚕️ About the Presenter: Dr. Faiza MBBS (Best Graduate, AIMC Lahore) FCPS (Physiology) ICMT, CHPE, DHPE (STMU) MPH (GC University, Faisalabad) MBA (Virtual University of Pakistan) She brings deep clinical and teaching experience to physiology, simplifying complex muscle-related topics with practical relevance.