Crimson Publishers-Management of Heterotopic Ossification of the Elbow in Patients with Elbow and Brain Injury a Retrospective Study

1/6
Volume 1 - Issue - 1
Introduction
The particular anatomical features of the elbow joint and its
relation to the hand and shoulder lead and define the functional
deficits after bony or soft tissue injury. Heterotopic ossification
is considered one of the most debilitating causes, which almost
always results in severe limitation of motion or complete ankylosis.
The prevalence of clinically significant HO in the traumatic
brain injury population is estimated to be 10-20% [1] or even
higher according to the literature [2]. Significant risk factors for
HO development include trauma, burns, immobility, limb spasticity,
and prolonged coma [3-5]. In traumatic brain injury HO tends to
occur in the connective tissue between the muscle planes and not
within the muscle itself [6], affecting in decreasing frequency the
hips, elbows, shoulders, knees, and rarely, the thigh [1].
Recent studies reported more favorable surgical results in
patients with HO than in those with other causes of stiffness [7-9].
However, HO has been considered as a poor prognostic factor after
surgical release with respect to recovery of elbow motion, with
some of the studies reporting a recurrence rate of 10% to 24% or
results showing fair to poor outcomes in more than 30% of studied
patients after surgical treatment [10]. The majority of the factors
that lead to these poor outcomes still remain poorly understood
[10,11].
The purpose of the present retrospective study was to report
the results of surgical treatment for post-traumatic elbow stiffness
caused by HO in patients with elbow trauma and brain injury
necessitating admission to intensive care unit, treated by the senior
surgeons (G.T) and (V.P).
Patients and Methods
Between September 2000 and October 2012, 28 patients who
fulfilled the following criteria were treated with open surgical
release by one of the two senior surgeons (G.T) or (V.P.): (1) Post-
traumatic stiff elbow (2) Traumatic brain injury with admission to
ICU unit (3)total arc of motion of less than 100° (4) HO visible on
preoperative X-ray (5) skeletally mature elbows without a history
of trauma and limitation in range of motion (ROM) before injury,
(6) evidence of union and stability of the joint, and (7) a normal or
minimally involved ulnohumeral joint (Figure 1).
D Skouteris1
, P Tsiasiotis1
, G Tsikouris2
and V Psychoyios1
*
1
Hand & Upper Extremity Service, Asclepeion Hospital, Greece
2
Orthopaedics & Sports Medicine Centre, Greece
*Corresponding author: Vassilios Psychoyios, Department of Orthopaedic, Hand Service, Asklepieion Hospital, Athens, Greece, Vasileos Paulou 1 Str.
16673, Voula, Athens, Greece
Submission: August 01, 2017; Published: September 15, 2017
Management of Heterotopic Ossification of the
Elbow in Patients with Elbow and Brain Injury a
Retrospective Study
Copyright © All rights are reserved by V Psychoyios.
Abstract
The elbow is a highly constrained hinge joint with a high propensity for stiffness after bony or soft tissue injury, and heterotopic ossification (HO)
after brain injury is considered one of the most debilitating causes resulting in severe limitation of motion and everyday activities.
The purpose of the present retrospective study was to report the results of surgical treatment for post-traumatic elbow stiffness caused by HO in
patients with elbow trauma and brain injury necessitating admission to intensive care unit.
Although surgical treatment of HO is technically demanding and accompanied by high complication rates, reasonable outcome can be expected
regardless of preoperative ROM or the type of brain injury, provided that upper limb does not a have any neurological deficit. While some loss of motion
from what significantly gained intra-operatively can be expected, a majority of patients who actively participate in their post-operative physical therapy
program will achieve an optimal outcome by preserving a functional arc of motion.
Keywords: Heterotopic ossification; Elbow joint stiffness; Brain injury
Abbreviations: HO: Heterotopic ossification; ICU: Intensive Care Unit
Case Report
Orthopedic Research
Online JournalC CRIMSON PUBLISHERS
Wings to the Research
ISSN: 2576-8875

How to cite this article: D Skouteris, P Tsiasiotis, G Tsikouris, V Psychoyios .Management of Heterotopic Ossification of the Elbow in Patients with Elbow and
Brain Injury a Retrospective Study. Ortho Res Online J. 1(1). OPROJ.000505. 2017. DOI: 10.31031/OPROJ.2017.01.000505
Orthopedic Research Online Journal
2/6
Ortho Res Online J
Figure 1: Typical case of elbow HO after olecranon fracture
and brain injury. This patient sustained a subarachnoid
hemorrhage and admitted to ICU for 20 days.
We were able to contact and re-examine 24 patients. There
were 16 men and 8 women with a mean age of 37 years (range 18-
67). In seventeen patients the dominant arm was involved. Two
patients had been lost from the follow up but their medical records
from the last outpatient clinic visit were available. One patient died
of unrelated reason and one patient refused to be re-examined. We
included in this retrospective study 24 patients that we were able
to re-examine clinically and radiographically. The mean follow-up
was 93.2 months (range, 44-201 months).
Regarding the head injury eight patients sustained a subdural
hematoma, five an epidural hematoma, four a subarachnoid
hemorrhage, and seven a diffuse cerebral edema (Table 1). Six
patients underwent a neurosurgical procedure on average of
approximately five hours after admission to the hospital. The elbow
trauma consisted of distal humerus fracture in five patients, an
olecranon fracture in three, in complex fracture dislocation of the
elbow in nine, radial head fracture in three, an elbow dislocation in
two, an MCL rupture in one and an open elbow dislocation in one
patient (Table 2) (Figure 2). Twenty patients underwent operative
fixation of their lesions. The average duration to ICU was 29 days
(range 17-86 days).
Figure 2: a) Open elbow dislocation in 27 yrs old patient who suffered from traumatic epidural hematoma.
b) Almost complete elbow ankylosis after 22 months of the original injury.
Table 1: Head injury lesions.
Subdural hematoma 8
Epidural hematoma 5
Subarachnoid hemorrhage 4
Cerebral edema 7
Table 2: Elbow injuries.
Distal humerus fracture 5
Olecranon fracture 3
Radial head fracture 3
Complex elbow fracture dislocation 9 Total
Terrible triad 3
Posterior Monteggia lesion 4
Transolecranon fracture dilocation 2
MCL rupture 1
Open elbow dislocation 1
Close elbow dislocation 2

3/6
Ortho Res Online JOrthopedic Research Online Journal
Surgical management
Excision of the heterotopic bone (formed) as well as elbow soft
tissue contracture release was performed utilizing well-described
surgical techniques in the literature [8,12-14]. Persistent loss of
elbow motion causing disability, limitation of daily activities, pain
anddurationofthesymptomsforatleastninemonthswithnosignof
improvement despite physical therapy were the clinical indications
for surgical intervention. A negative bone scan and normal levels
of alkaline phosphatase were the main laboratory indicators of
heterotopic bone maturity until 2004. Since then we abandoned
their use, as according to our limited experience and the literature
in matter, ALP is not considered a reliable screening method for
early HO detection [15,16]. Furthermore, bone scintigraphy has
limited value for evaluating the maturity of ossification and is little
used in clinical practice [8]. Our main criteria for excision after
2004 were the clinical status, as described above, and a stabilized
lesion radiographically.
Approach was determined by previous skin incisions, presence
of ulnar neuropathy, location of the heterotopic bone and status
of the radial head. A long posterior midline incision was used in
18 patients, a combination of medial and lateral incision in two, a
lateral in two, amedial in one and an anterior in one (Figure 3).
Figure 3: Various approaches utilized for the HO excision from elbow joint
a) A long posterior incision gives access posteriorly, anteriorly medially and laterally to the elbow joint.
b) Medial and lateral approach utilized separately to excise HO from the medial lateral and lateral aspect of the elbow joint.
c) An anterior approach to the elbow joint. Utilized very rarely and in specific cases of HO location at the anterior elbow surface.
d) A medial approach to elbow joint. In this particular case after excision of the HO through the flexor-pronator mass.
Figure 4: Large medial and lateral fasciocutaneous flaps.
Identification and protection of the ulnar nerve (yellow
arrow).
In a posterior approach a large medial and lateral full thickness
fasciocutaneous flaps were created and the ulnar nerve was
identified and released up to the proximal aspect of the flexor carpi
ulnaris (FCU) muscle and protected (Figure 4). After dissection of
the triceps muscle from the posterior humerus, a complete excision
of the posterior capsule was performed as well as excision of
heterotopic bone from the posterior aspect of the joint, especially
around the olecranon and the olecranon fossa. If necessary, the
posterior band of the MCL was released, until gaining flexion up
to 130 degrees or more. When forearm motion was limited the
Kocher interval was developed and an anterior capsulectomy
was performed in combination with excision of heterotopic bone
whenever it was present. In five cases a radial head excision
was undertaken due to enormous enlargement from chondral
metaplasia, after radial head fracture (Figure 5). In six cases a
medial approach through the flexor-pronator mass was developed,
one primarily and the rest as a part of another approach, in order
to completely excise the anterior capsule and achieve full extension
of the joint.
Figure 5: Elbow HO after brain injury and Radial head
fracture.
a)HO in the lateral and medial side.
b)Radial head chondral metaplasia
Hardware for fracture fixation was removed in all patients. In
one patient a supracondylar fracture was created attempting to
gain full extension, and treated with k-wires (Figure 6). In three

4/6
Ortho Res Online J
patients a pie crust triceps lengthening/release was performed to gain additional flexion.
Figure 6: Iatrogenic fracture after excision of the Elbow HO in attempting to gain full ROM.
a) Elbow HO affecting all the elbow surfaces after elbow dislocation.
b) Supracondylar elbow fracture after HO excision, treated with k-wires.
c) Profile view from the same elbow xray.
The lateral collateral ligament was accidentally detached from
its humeral insertion in one patient and repaired with transosseous
sutures. The ulnar nerve was transposed subcutaneously in twenty-
one patients either as a preventive or as a therapeutic procedure.
Bone wax was applied onto all bony surfaces from which bone was
excised.
A long arm splint with the elbow in full extension was applied
onto the anterior aspect of the joint (Figure 7). Active assisted and
passive flexion-extension exercise begun the first postoperative
day. Indomethacin 75mg was administered twice daily for six
weeks in order to prevent a new ectopic bone formation. An
intensive physiotherapy program was followed and a turnbuckle
splint was applied after edema subsidence, usually after the third
postoperative week. The mean duration of physical therapy was
5 months and the mean duration of the turnbuckle splint usage
was 11 months. No adjuvant radiation therapy was used, although
its true value in HO management is still debated. According to
Cipriano et al. [17] local radiation was not effective in patients with
neurogenic HO. On the other hand, studies on patients with HO
after spinal cord injuries treated with adjuvant radiation therapy
indicate significant improvement in ROM [18,19].
Figure 7: A long arm anterior splint applied with elbow
joint in full extension.
Results
The average arc of elbow motion improved from 40° (range 0°-
80°) pre operatively to 110° (range 0°-140°), with an improvement
of 70° at the final follow-up evaluation. The mean Mayo Elbow
Performance Index MEPI score was 89.9 (range, 60-100). Results
were good to excellent in 18 patients, fair in 5 patients, and poorin
one (Table 3). Among the 24 study patients, 19 (79.1%) obtained a
total ROM of 100oat the final evaluation, and 3 underwent repeated
surgical release due to recurrence of contracture. In two of them a
recurrence of HO was present 9 months on average postoperatively.
Patients who required repeated surgical release had an average arc
of flexion-extension of 70° at the time of their second surgery and
an average of 90° after their second elbow release at final evaluation
for the needs of the present paper.
Table 3: Preop and Postop ROM and the Mayo Elbow Performance
Index.
Preop Postop
Av E/F 45( 35- 85) 110(0-140)
Av S/P 100(45-55) 165(75-85)
MEPI score 45 89.1
Five patients did not gain an arc of >100, and in two of them
recurrence of HO was regarded as the major reason of failure. In
the rest three patients a severe osteoarthritis was developed and
considered as the main reason of the failure.
There was one iatrogenic injury to the lateral ligamentous
complex and one iatrogenic fracture of the distal humerus, treated
accordingly. Three patients developed a mildly valgus deformed
elbow without clinical consequences. Three patients underwent
a second procedure, a transmuscular ulnar nerve transposition
together with internal neurolysis, due to tardy ulnar nerve palsy
75 months on average of 100 months after the index procedure.
Recurrent HO was observed in two patients postoperatively, one of
them denied any further treatment.

5/6
Ortho Res Online JOrthopedic Research Online Journal
Discussion
The goal of our study was to assess the outcome in improvement
of the range of motion of the elbow and of the daily activities after
surgical release of elbow stiffness caused by HO after elbow trauma
and concomitant brain injury.
Thus we can state that a very reasonable outcome can be
expected regardless of preoperative ROM or the type of brain injury,
provided that upper limb does not a have any neurological deficit.=
In the past HO has been considered as a poor prognostic factor
after elbow trauma [10,20,21]. Due to the extensive loss in ROM,
the high recurrence rates of HO and complications after surgical
treatment, the decision making for operative intervention was a
less attractive option.
Nowadays, although surgical treatment of HO is technically
demanding and accompanied by high complication rates, there are
studies which report good results after surgical treatment of elbow
stiffness due to HO [4,22-24]. Accordingly, there are studies that
demonstrate better results for the HO group in comparison with
the capsular contracture group after surgical treatment 7. However,
the are no studies evaluating the outcome of surgical release in
patients with elbow trauma and brain injury, admitted for a period
of time to ICU.
We attempted to evaluate the results especially in this
subcategory of patients and to extract conclusions, although
retrospectively, regarding the feasibility of the procedure, the
outcome regarding ROM and ability to perform daily activities.
Furthermoreduetocomplexityofthoseproceduresweencountered
the potentials risks and tried to find ways to avoid or fix them.
Excision of heterotopic bone as well as release of contracture
or ankylosis about the elbow requires a very sound knowledge of
anatomy in this particular area. A posterior skin incision offers a
global approach to elbow surfaces and deep structures. Substantial
improvement in elbow and forearm range of motion can be
anticipated following the procedure described although a high
complication rate early or delayed can interrelate these procedures.
Every patient should be treated with an aggressive rehabilitation
protocol that includes prolonged physical therapy as well as use of
turnbuckle splint14. Adjuvant treatment with indomethacin should
be utilized in every patient as various studies seem to support the
efficacy of NSAIDs and indomethacin in particular [4,25]. While
somelossofmotionfromwhatsignificantlygainedintra-operatively
can be expected, a majority of patients who actively participate in
their physical therapy program will achieve an optimal outcome by
preserving a functional arc of motion.
Conflict of Interest
All the authors certify that they have NO affiliations with
or involvement in any organization or entity with any financial
interest (such as honoraria; educational grants; participation in
speakers’ bureaus; membership, employment, consultancies, stock
ownership, or other equity interest; and expert testimony or patent-
licensing arrangements), or non-financial interest (such as personal
or professional relationships, affiliations, knowledge or beliefs) in
the subject matter or materials discussed in this manuscript.
References
1. Chan, Kwai-Tung (2005) Heterotopic Ossification in Traumatic Brain
Injury. American Journal of Physical Medicine & Rehabilitation
84(2):145-146.
2. Cipriano CA, Pill SG, Keenan MA (2009) Heterotopic ossification
following traumatic brain injury and spinal cord injury. J Am Acad
Orthop Surg 17(11): 689-697.
3. Abrams GD, Bellino MJ, Cheung EV (2012) Risk factors for development
of heterotopic ossification of the elbow after fracture fixation. J Shoulder
Elbow Surg 21(11): 1550-1554.
4. Sandeep KN, Suresh G, Gopisankar B, Abhishek N, Sujiv A (2017) Does
excision of heterotopic ossification of the elbow result in satisfactory
patient-rated outcomes? Malays Orthop J 11(1): 35-40.
5. Garland DE, Orwin JF (1989) Resection of heterotopic ossification in
patients with spinal cord injuries. Clin Orthop Relat Res 242: 169-176.
6. Jensen LL, Halar E, Little J, Brooke MM (1987) Neurogenic heterotopic
ossification. Am J Phys Med Rehabil; 66(5): 351-363.
7. Lindenhovius AL, Linzel DS, Doornberg JN, Ring DC, Jupiter JB (2007)
Comparison of elbow contracture release in elbows with and without
heterotopic ossification restricting motion. J Shoulder Elbow Surg 16(5):
621-625.
8. Filho GM, Galvao MV (2010) Post-traumatic stiffness of the elbow. Rev
Bras Ortop 45(4): 347-356.
9. Ring D, Jupiter JB (2004) Operative release of ankylosis of the elbow
due to heterotopic ossification. Surgical technique. J Bone Joint Surg Am
86(Suppl 1): 2-10.
10. Koh KH, Lim TK, Lee HI, Park MJ (2013) Surgical treatment of elbow
stiffness caused by post-traumatic heterotopic ossification. J Shoulder
Elbow Surg 22(8): 1128-1134.
11. Moreta J, Luis Martinez-de los Mozos J (2014) Heterotopic ossification
after traumatic brain injury, Chapter 15. Traumatic Brain Injury 1222-
1228.
12. Morrey BF (1990) Post-traumatic contracture of the elbow. Operative
treatment, including distraction arthroplasty. J Bone Joint Surg Am
72(4): 601-618.
13. Morrey BF (2005) The posttraumatic stiff elbow. Clin Orthop Relat Res
431: 26-35.
14. Dodds SD, Hanel DP (2006) Heterotopic Ossification of the Elbow. In:
Trumble TE, (Ed.), Wrist and Elbow Reconstruction & Arthroscopy.
Rosemont, American Society for Surgery of the Hand, USA, pp. 425‐438.
15. Singh RS, Craig MC, Katholi CR, Jackson AB, Mountz JM (2003) The
predictive value of creatine phosphokinase and alkaline phosphatase
in identification of heterotopic ossification in patients after spinal cord
injury. Arch Phys Med Rehabil 84(11): 1584-1588
16. Citak M, Grasmucke D, Suero EM, Cruciger O, MeindL R, et al. (2016)
The roles of serum alkaline and bone alikaline phosphatase levels in
predicting heterotopic ossification following spinal cord injury. Spinal
Cord 54(5): 368-370.
17. Cipriano C, Pill SG, Rosenstock J, Keenan MA (2009) Radiation therapy
for preventing recurrence of neurogenic heterotopic ossification.
Orthopedics 32(9).
18. Sautter-Bihl ML, Hultenschmidt B, Liebermeister E, Nanassy A
(2001) Fractionated and single dose radiotherapy for heterotopic
bone formation in patients with spinal cord injury. A phase I/II study.
Strahlenther Onkol 177(4): 200-205.

6/6
Ortho Res Online J
19. Sakellariou VI, Grigoriou E, Mavrogenis AF, Soucacos PN, Papagelopoulos
PJ (2012) Heterotopic Ossification Following Traumatic Brain Injury
and Spinal Cord Injury: Insight Into the Etiology and Pathophysiology. J
Musculoskelet Neuronal Interact 12(4): 230-240.
20. Jupiter JB, O’Driscoll SW, Cohen MS (2003) The assessment and
management of the stiff elbow. Instr Course Lect 52: 93-111.
21. Viola RW, Hastings H (2000) Treatment of ectopic ossification about the
elbow. Clin Orthop Relat Res 370: 65-86.
22. Salazar D, Golz A, Israel H, Marra G (2014) Heterotopic ossification of the
elbow treated with surgical resection: risk factors, bony ankylosis, and
complications. Clin Orthop Relat Res 472(7): 2269-2275.
23. Baldwin K, Hosalkar HS, Donegan DJ, Rendon N, Ramsey M, et al. (2011)
Surgical resection of heterotopic bone about the elbow: an institutional
experience with traumatic and neurologic etiologies. J Hand Surg Am
36(5): 798-803.
24. Park MJ, Chang MJ, Lee YB, Kang HJ (2010) Surgical release for
posttraumatic loss of elbow flexion. J Bone Joint Surg Am 92(16): 2692-
2699.
25. Fransen M, Neal B (2004) Non-steroidal anti-inflammatory drugs for
preventing heterotopic bone formation after hip arthroplasty. Cochrane
Database of Syst Rev 3: CD001160.

Crimson Publishers-Management of Heterotopic Ossification of the Elbow in Patients with Elbow and Brain Injury a Retrospective Study

More Related Content

What's hot (18)

Similar to Crimson Publishers-Management of Heterotopic Ossification of the Elbow in Patients with Elbow and Brain Injury a Retrospective Study (20)

More from CrimsonPublishersOPROJ (20)

Recently uploaded (20)

Crimson Publishers-Management of Heterotopic Ossification of the Elbow in Patients with Elbow and Brain Injury a Retrospective Study