C.V. David Labbé, M.Sc., agr., chm.
- 1. DAVID LABBÉ, M.Sc., agr., chm. EMail: [email protected] LinkedIn: ca.linkedin.com/in/labbedavid EXPERIMENTAL MEDICINE Ph.D. CANDIDATE Deeply involved student with great marks who have also proven able to carry on, publish and communicate research projects in multiple fields. Very active student who’s passionate for research and has a deep faith in the multidisciplinary approach. Worked in a number of laboratories since the beginning of undergraduate studies. Has proven able to carry out research projects and produce publications of high quality in the Cancer and Food Sciences research fields. Demonstrated abilities to communicate scientific issues in collaboration with the only magazine aimed at the Québec food industry in French, l’Actualité Alimentaire. Obtained international experience during undergraduate studies. Possesses good basis in management. EDUCATION Experimental Medicine (Ph.D.) 2008-present McGill University, Goodman Cancer Research Center, Montréal Ph.D. thesis: Protein tyrosine phosphatase 1B (PTP1B) gene regulation and role in prostate cancer Supervisor, Dr Michel L. Tremblay Chemistry, specialization in biochemistry (M.Sc.) 2008 Université du Québec à Montréal/Hôpital Sainte-Justine, Montréal Master thesis: Les flavonoïdes d’origine alimentaire et le cancer – Inhibition de l’angiogenèse tumorale et du potentiel invasif des médulloblastômes Supervisor, Dr Richard Béliveau • Master’s thesis accepted with an ”excellent” rating • Degree obtained with honours Administration (certificate) 2007 Université Laval, Québec • Specialization in management Food Sciences, experience abroad (B.Sc.A.) 2006 Université Laval, Québec • Semester at the ”Polytech’Montpellier”, France • Specialization in chemistry BILINGUAL: French and English PROFESSIONAL ORDERS: • Agrologist, member of the “Ordre des agronomes du Québec”. • Chemist, member of the “Ordre des chimistes du Québec”.
- 2. DAVID LABBÉ, agr., chm., M.Sc. Page 2 / 10 AWARDS AND PRIZES Research awards Award name Organization Amount Date Rolande and Marcel Gosselin Graduate Studentship McGill University 11,000 2011-2012 McGill Integrated Cancer Research Training Program CIHR/FRSQ 12,000 2011-2012 Frederick Banting and Charles Best doctoral research award CIHR 105,000 2008-2011 Doctoral research award (declined) FRSQ 60,000 2008-2011 Master research award FQRNT 15,000 2007 Canada Graduate Scholarship – Master’s NSERC 17,500 2006 Undergraduate Student Research Award NSERC 5,625 2006 Internship award “Excellence” Ordre des chimistes du Québec 5,000 2005 Undergraduate Student Research Award NSERC 5,625 2004 Undergraduate Student Research Award NSERC 5,625 2003 Prizes Award name Organization Amount Date Graduate Research Enhancement & Travel (GREAT) Award McGill University 1,500 2012 Travel award McGill Integrated Cancer 1,000 2011 (Europhosphatase 2011, Vienna, Austria) Research Training Program Travel award Canderel 500 2010 (FASEB meeting, Steamboat Springs, CO) Phil Gold Scientist in Training Award MISAM 100 2009 (3rd best poster presentation) National Student Research Poster Competition CIHR (declined) - 2009 (Winnipeg, Manitoba) Travel award Canderel 500 2009 (Cold Spring Harbor meeting, Cold Spring Harbor, NY) Best poster presentation CHU Sainte-Justine 150 2007 (Centre de recherche du CHU Sainte-Justine, Montréal) Second rank Can. Inst. Food. Sci. and Tech. - 2006 (Student Challenge opposing 7 canadian universities) Second best poster presentation FAV Health 2005 100 2005 Academic awards Award name Organization Amount Date Graduate Excellence Fellowship McGill University 1,500 2012 Principal’s Graduate Fellowship McGill University 2,500 2009-2010 Provost’s Graduate Fellowship McGill University 5,500 2008-2009 Junior/Senior Scholarship Institute of Food Technologist (USA) 1,000 2006 Excellence award Canadian Inst. of Food Science and Tech. 1,000 2005 Award Fondation de technologie laitière du Québec inc. 500 2005 Junior/Senior Scholarship Institute of Food Technologist (USA) 1,000 2005 Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2005 Studentship studies abroad, France Université Laval 3,000 2004 Excellence award Canadian Inst. of Food Science and Tech. 1,000 2004 Excellence award Promotion Agronomie 1965, Université Laval 1,500 2004 Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2004 Excellence award Canadian Inst. of Food Science and Tech. (Québec) 800 2003 Excellence award Faculty (FSAA), Université Laval 1,000 2002 Summer English language program Minister of Canadian Heritage 1,625 2002
- 3. DAVID LABBÉ, agr., chm., M.Sc. Page 3 / 10 RESEARCH EXPERIENCE Development of a preconcentration method for green tea catechins 2006 • Research internship (NSERC), Université Laval, Québec Dr Laurent Bazinet Optimisation of an electrodialysis method for green tea catechins separation 2005 • Research collaboration, Institut européen des membranes (IEM), Montpellier, France Dr Philippe Sistat and Dr Laurent Bazinet Nutritional impact of chitosan on rats under a cholesterol and saturated fat-rich diet 2005 • Exploratory study, Polytech’Montpellier, Université de Montpellier II, France Dr Jean-Max Rouanet and Dr Bernard Possompes Green tea polyphenols electromigration with ultrafiltration membranes 2004 • Research internship (NSERC), Université Laval, Québec Dr Laurent Bazinet Study on the maturation of cheese 2004 • Industrial research internship, Les Fromages de l’isle d’Orléans, Québec Dr Jacques Goulet Study on the green tea polyphenols electromigration potential 2003 • Research internship (NSERC), Université Laval, Québec Dr Laurent Bazinet Production of emulsifier molecules by enzymatic means 2003 • Research internship, Université Laval, Québec Dr Jean-Christophe Vuillemard SKILLS AND TECHNIQUES Food sciences Biochemistry Experimental Medicine •Bioactive molecule extraction •Tissue culture •Transgenic mouse models •Electrodialysis •Cellular biology •Murine prostate cancer model •HPLC •Biochemical assays •Xenograft assays •Green tea •Gene regulation studies •Clinical studies •Microarrays •Immunohistochemistry
- 4. DAVID LABBÉ, agr., chm., M.Sc. Page 4 / 10 SCIENTIFIC PUBLICATIONS ARTICLES 1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer, Cancer Research, epub ahead of print (2012) January 26th. *Contributed equally to the work Top Story: Prostate Cell News, 3.03, January 27, 2012 Publication of the Month: Goodman Cancer Research Centre, January 2012 2. Provençal, M.; Berger-Thibault, N.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.; Béliveau, R. Tissue factor mediates the HGF/MET-induces anti-apoptotic pathway in medulloblastoma cells, Journal of Neuro-Oncology, 97(3) (2010) 365-372. 3. Provençal, M.; Labbé, D.; Veitch, R.; Boivin, D.; Rivard, G-É.; Gingras, D.; Béliveau, R. c-Met activation in meduloblastoma induces tissue factor expression and activity: effects cell migration, Carcinogenesis, 30(7) (2009) 1089-1096. 4. Boivin, D.; Labbé, D.; Fontaine, N.; Lamy, S.; Beaulieu, É.; Gingras, D.; Béliveau, R. The stem cell marker CD133 (prominin-1) is phosphorylated on cytoplasmic tyrosine-828 and tyrosine-852 by Src and Fyn tyrosine kinase, Biochemistry, 48(18) (2009) 3998-4007. 5. Labbé, D.; Provençal, M.; Lamy, S.; Boivin, D.; Gingras, D.; Béliveau, R. The flavonols quercetin, kaempferol and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration, The Journal of Nutrition, 139(4) (2009) 646-652. 6. Lamy, S.; Bédard, V.; Labbé, D.; Sartelet, H.; Barthomeuf, C.; Gingras, D.; Béliveau, R. The dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-! phosphorylation, Cancer Prevention Research 1(6) (2008) 452-459. 7. Lamy, S.; Beaulieu, É.; Labbé, D.; Bédard, V.; Moghrabi, A.; Barette, S.; Gingras, D.; Béliveau, R. Delphinidin, a dietary anthocyanidin, inhibits platelet derived growth factor ligand/receptor (PDGF/PDGFR) signaling, Carcinogenesis, 29(5) (2008) 1033-1041. 8. Labbé, D.; Têtu, B.; Trudel, D.; Bazinet, L. Catechin stability of EGC- and EGCG-enriched tea drinks produced by a two-step extraction procedure, Food Chemistry, 111 (2008) 139-143. 9. Bazinet, L.; Labbé, D.; Tremblay A. Production of green tea EGC- and EGCG-enriched fractions by a two-step extraction procedure, Separation and Purification Technology, 56 (2007) 53-56. 10. Labbé, D.; Bazinet, L. Effect of membrane type on cation migration during green tea electromigration and equivalent mass transported calculation, Journal of Membrane Science, 275 (2006) 220-228.
- 5. DAVID LABBÉ, agr., chm., M.Sc. Page 5 / 10 11. Labbé, D.; Tremblay, A.; Bazinet, L. Effect of brewing temperature and duration on green tea catechin solubilization: basis for production of EGC and EGCG-enriched fractions, Separation and Purification Technology, 49 (2006) 1-9. 12. Labbé, D.; Araya-Farias, M.; Tremblay, A.; Bazinet, L. Electromigration feasability of green tea catechins, Journal of Membrane Science, 254 (2005) 101-109. REVIEW Trudel, D.; Labbé, DP.; Bairati, I.; Fradet, V.; Bazinet, L.; Têtu, B. Green tea for ovarian cancer prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies, Gynecologic Oncology, submited #GYN-12-116. BOOK CHAPTER Labbé, DP.; Hardy, S.; Tremblay, ML. Protein tyrosine phosphatases in cancer: Friends and Foes!, in Protein Phosphorylation and Health and Disease an issue of Progress in Molecular Biology and Translational Science (Shenolikar, S. ed.), Academic Press. 106 (2012) 253-306. BROAD INTEREST PUBLICATIONS 1. Labbé, D. Inflammation et cancer : Quand le système immunitaire se retourne contre soi, Sciences express (UQÀM), 2008, vol. 7, n° 9. 2. Labbé, D. Être à l’affût : un défi de pointe, L’Actualité alimentaire, 2006, vol. 3, n° 3, p. 46-49. 3. Labbé, D. S’afficher sans allergènes, L’Actualité alimentaire, 2006, vol. 3, n° 2, p. 52-55. 4. Labbé, D. La modélisation au service de l’optimisation, L’Actualité alimentaire, 2005, vol. 2, no 6, p. 42-44. 5. Labbé, D. L’extraction de molécules bioactives, L’Actualité alimentaire, 2005, vol. 2, no 5, p. 44-47. 6. Labbé, D. Les technologies membranaires flirtent avec les nutraceutiques, L’Actualité alimentaire, 2005, vol. 2, no 1, p. 46-48. 7. Labbé, D. Produire sans lait, sans œufs ou sans gluten : Un casse-tête nécessaire, L’Actualité alimentaire, 2004, vol. 1, no 6, p. 44. 8. Labbé, D. Transformer bio, un noble défi! L’Actualité alimentaire, 2004, vol. 1, no 6, p. 42-43. 9. Labbé, D. L’aspirine, un remède aux allergies alimentaires? Le Ligand, mars 2003, vol. 14, no 1, p. 3.
- 6. DAVID LABBÉ, agr., chm., M.Sc. Page 6 / 10 PATENTS 1. Bazinet, L.; Labbé, D.; Tremblay, A. Method for selectively and sequentially extracting catechins from plant product. North American # US2005176939. 2. Bazinet, L.; Amiot, J.; Poulin, J.-F; Tremblay, A.; Labbé, D. Process and system for separation of organic charged compounds. Worldwide #WO2005082495. Reviewer (peer-reviewed journal) Current Oncology 2010- PRESENTATIONS ORAL PRESENTATIONS 1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase associated with tumor-promoting functions in prostate cancer. 12th Annual McGill Biomedical Graduate Conference, Montréal (Québec), February 16th 2012. *Contributed equally to the work 2. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase associated with tumor-promoting functions in prostate cancer. Phosphatases in Human Disease, Melbourne, Australia, February 3rd-4th 2012. *Contributed equally to the work 3. *Labbé, D.; *Lessard, L.; Deblois, G.; Hardy, S.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Giguère, V.; and Tremblay, ML. Protein tyrosine phosphatase 1B is regulated by the androgen receptor and plays a tumor-promoting role in prostate cancer. Europhosphatase 2011 (EMBO Conference Series); Protein Phosphatases: From Molecules to Networks, Vienna, Austria, July 18th- 23rd 2011. *Contributed equally to the work 4. Labbé, D. PTP1B is regulated by the androgen receptor and plays a tumor-promoting role in prostate cancer. Work In Progress (WIP) talk, Goodman Cancer Research Centre, McGill University, Montréal (Québec) January 18th 2011. 5. Labbé, D. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Journal Club, Goodman Cancer Research Centre, McGill University, Montréal (Québec), November 26th 2010.
- 7. DAVID LABBÉ, agr., chm., M.Sc. Page 7 / 10 6. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit la surexpression du facteur tissulaire dans les médulloblastomes. 4th annual meeting of the “Centre de Recherches Biomédicales (BioMed)”, Université du Québec à Montréal, Montréal (Québec), April 30th 2008. 7. Labbé, D. Sciences et médias : Information ou désinformation? 2nd “Colloque des chercheurs étudiants et postdoctoraux de l’Institut des nutraceutiques et des aliments fonctionnels (INAF)”, Château Bromont, Bromont (Québec), November 1-2 2007. 8. Trudel, D.; Bairati, I.; Bazinet, L.; Labbé, D.; Plante, M.; Bachvarov, D.; Overall, C.; Jones, T. Green tea intake for maintenance of complete remission in women with advanced stage ovarian cancer. 45th “Journée scientifique annuelle Carlton-Auger”, Québec (Québec), October 12-13 2007. Published abstract: Annales de pathologie 28(1) (2008) 71-75. 9. Labbé, D. Serions-nous tous mal nourris? Invited panelist at the “Forum des jeunes en sciences”, Collège Montmorency, Laval (Québec), November 6th 2006. 10. Labbé D.; Araya-Farias, M.; Tremblay A.; Bazinet L. Effet du type de membrane sur la migration des cations au cours de l’électromigration de thé vert et le calcul des équivalents-masses transportés. “Journée d’information scientifique et technique en génie agroalimentaire”, Saint-Hyacinthe (Québec), March 23rd 2005. 11. Bazinet, L.; Labbé, D.; Tremblay, A. Production d’une fraction enrichie en EGCG du thé vert par une procédure d’extraction en deux étapes. 72nd “Congrès de l’ACFAS, discipline chimie-physique, inorganique et des surfaces”, UQAM, Montréal (Québec), May 13th 2004. 12. Bazinet, L.; Labbé, D.; Tremblay, A. Effect of temperature and brewing duration on solubilization of green tea catechins. First Natural Health Product Research Conference organized by the Natural Health Product Research Society of Canada, Montréal (Québec), February 20-22 2004. POSTER PRESENTATIONS 1. *Labbé, DP.; *Lessard, L.; Deblois, G.; Bégin, LR.; Hardy, S.; Mess-Masson, AM.; Saad, F.; Trotman, LC.; Giguère, V.; Tremblay, ML. PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Poster presented at the PTEN Pathways & Targets, Cold Spring Harbor, New York (USA), March 13-16 2012. *Contributed equally to the work 2. Hardy, S.; Wong, NN.; Labbé, D.; Aubry, I.; Lessard, L.; Bégin, LR.; Saad, F.; Mes-Masson, A-M.; Kerr, R.; Tremblay, ML. Regulation of phosphatase of regenerating liver-2 (PRL-2) in cancer. Poster presented at the Europhosphatase 2011 (EMBO Conference Series); Protein Phosphatases: From Molecules to Networks, Vienna, Austria, July 18-23 2011.
- 8. DAVID LABBÉ, agr., chm., M.Sc. Page 8 / 10 3. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotes tumorigenesis in prostate cancer. Poster presented at the Montréal International Symposium on Angiogenesis and Metastasis (MISAM 2011), Montréal (Québec), June 15-17 2011. *Contributed equally to the work 4. Tremblay, ML.; *Labbé, D.; *Lessard, L.; Bégin, LR.; Filion, M.; Leloy, A.; Filion, M.; Saad, F.; Mes- Masson, A-M. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells. Poster presented at the Innovative Minds in Prostate Cancer Today (IMPaCT) Conference, Orlando, Florida (USA), March 9-12, 2011. *Contributed equally to the work 5. *Labbé, D.; *Lessard, L.; Hardy, S.; Deblois, G.; Bégin, LR.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Giguère, V.; and Tremblay, ML. PTP1B is regulated by the androgen receptor and promotes tumorigenesis in prostate cancer. Poster presented at the 9th Conference on Signaling in Normal and Cancer Cells, Banff (Alberta), March 6-10 2011. *Contributed equally to the work 6. *Labbé, D.; *Lessard, L.; Deblois, G.; Filion, M.; Giguère, V.; Tremblay, ML. Androgen-dependent regulation of PTP1B expression and activity. Poster presented at the FASEB Summer Research Conferences “Protein Phosphatases”, Steamboat Springs, Colorado (USA), July 18-23 2010. *Contributed equally to the work 7. *Labbé, D.; *Lessard, L.; Bégin, LR.; Leloy, A.; Filion, M.; Saad, F.; Mes-Masson, A-M.; Tremblay, ML. Inhibition of PTP1B attenuates the tumorigenic properties of prostate cancer cells. Poster presented at the FASEB Summer Research Conferences “Protein Phosphatases”, Steamboat Springs, Colorado (USA), July 18-23 2010. *Contributed equally to the work 8. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras, D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity: Effects on cell migration. Poster presented at the Montréal International Symposium on Angiogenesis and Metastasis (MISAM 2009), Montréal (Québec), June 11-12 2009. 9. Labbé, D.; Provençal, M.; Veitch, R.; Boivin, D.; Rivard, G-E.; Sartelet, H.; Robitaille, Y.; Gingras, D.; Béliveau, R. c-Met activation in medulloblastoma induces tissue factor expression and activity: Effects on cell migration. Poster presented at Phosphorylation, signaling & disease, Cold Spring Harbor, New York (USA), May 12-16 2009. 10. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire, de nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the “XXIIIe Congrès annuel de la recherche des étudiants gradués et post-gradués du Centre de recherche du CHU Sainte-Justine”, Montréal (Québec), June 12th 2008.
- 9. DAVID LABBÉ, agr., chm., M.Sc. Page 9 / 10 11. Labbé, D.; Provençal, M.; Lamy, S.; Gingras, D.; Béliveau, R. Les flavonols d’origine alimentaire, de nouveaux inhibiteurs du récepteur au facteur de croissance hépatocytaire. Poster presented at the 4th “Colloque annuel du Centre de Recherches Biomédicales (BioMed) de l’Université du Québec à Montréal”, Montréal (Québec), April 30th 2008. 12. Provençal, M.; Labbé, D.; Gingras, D.; Béliveau, R. Le facteur de croissance hépatocytaire induit la surexpression du facteur tissulaire dans les médulloblastomes. Poster presented at the 4th “Colloque annuel du Centre de Recherches Biomédicales (BioMed)” UQAM, Montréal (Québec), April 30th 2008. 13. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénol d’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the XXIInd “Congrès annuel de la recherche des étudiants gradués du Centre de recherche du CHU Sainte- Justine”, Montréal (Québec), May 15-16 2007. 14. Labbé, D.; Lamy, S.; Beaulieu, E.; Bédard, V.; Béliveau, R. La delphinidine, un polyphénol d’origine alimentaire, inhibe l’angiogenèse in vitro et in vivo. Poster presented at the 3rd “Colloque annuel Biomed”, UQAM, Montréal (Québec), May 2nd 2007. 15. Labbé, D.; Tremblay, A.; Bazinet, L. Electromigration feasability of green tea catechins. Poster presented at the “International Congress on Membranes and Membrane Processes (ICOM 2005)”, Seoul (South Korea), August 21-25 2005. 16. Labbé, D.; Vignal, E.; Sistat, P.; Bazinet, L. Separation of green tea catechins by electrodialysis with ultrafiltration membranes. Poster presented at the “International Symposium on Human Health : effects of fruits and vegetables (FAV Health 2005)”, Québec (Québec), August 17-20 2005. Published abstract: Acta Hort. (ISHS) 744 (2007) 369-376. 17. Labbé, D.; Tremblay, A.; Araya-Farias, M.; Bazinet, L. Séparation et purification des catéchines d’une infusion de thé vert par électromigration. Poster presented at the “Alimentation fonctionnelle et nutraceutiques : approches innovatrices en santé” meeting co-organized by the CQVB / INAF during the 72nd “Congrès de l’ACFAS”, UQAM, Montréal (Québec), May 13th 2004.
- 10. DAVID LABBÉ, agr., chm., M.Sc. Page 10 / 10 AFFILIATIONS Alumni association, Université Laval 2006- Association of scientific communicators of Québec 2005- Canadian Institute of Food Science and Technology 2003- Institute of Food Technologists (USA) 2003- EXTRACURRICULAR INVOLVEMENT Representative • Academic council of the Faculty of Sciences, Université du Québec à Montréal 2008 • Faculty council of the Faculty of Agricultural Sciences and Food, Université Laval 2004 • Linking commitee with the “Ordre des agronomes du Québec” 2003-2004 Food Science student association • President and VP of the external affairs 2003-2006 • President of the organizing comitee “15 e Colloque STA” (more than 160 food 2003 science professionals participate at this meeting). • President of organizing comittee for first year welcoming events (Food Science) 2003 • Organizer of the “Food Science wine and cheese” 2003 Volunteer • Défi Canderel 2009, 2010 • Salon de l’agriculture, de l’alimentation et de la consommation (SAAC) 2003, 04, 06 • Mathematics tutor 2001