Disease progrssion
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This document outlines the breast cancer continuum and possibilities for intervention at different stages: 1) It describes various pre-malignant conditions like LCIS and ADH, as well as prevention efforts that can be taken for women at increased risk of developing breast cancer. 2) It then covers non-invasive cancers like DCIS and efforts to prevent contralateral breast cancer. 3) The final stages discussed are early stage node negative/positive cancers, late stage cancers, and recurrence of breast cancer, with a focus on prevention of progression and recurrence.
Disease progrssion
- 1. Breast Cancer Continuum: intervention possibilities Prevention of ClinicallyPrevention of Clinically Detectable Breast CancerDetectable Breast Cancer Prevention of ClinicallyPrevention of Clinically Detectable Breast CancerDetectable Breast Cancer Pre- Malignant Conditions LCIS 6.5% ADH 5.1% Women at Increased Risk 1.7 % to 14% Non- Invasive Cancer DCIS 7.2% Prevention of ContralateralPrevention of Contralateral Breast Cancer 3.2%Breast Cancer 3.2% Prevention of ContralateralPrevention of Contralateral Breast Cancer 3.2%Breast Cancer 3.2% Tumors < 1cm 11.8% Early Stage node neg 25.1% Early Stage node pos 47.1% Prevention of Recurrence Late Stage Cancer Recurrence of Breast Cancer Prevention of Progression
- 2. With thanks to Professor W.Jonat Breast Cancer staging
- 3. With thanks to Professor W.Jonat Breast Cancer staging 2
- 4. With thanks to Professor W.Jonat Breast Cancer staging 3
- 6. Stages of tumour development Malignant cell Dissemination of other organs Invasion Proliferation Angiogenesis Neovascular endothelial maintenance Invasion Cytotoxics Endocrine EGFR inhibitors HER2 antibodies Anti- angiogenics Vascular targeting agents Novel agents Novel agents Metastatic Cancer of other organs
- 7. Staging Classification of Breast Tumour