DISQUS is a comment system that handles high volumes of traffic, with up to 17,000 requests per second and 250 million monthly visitors. They face challenges in unpredictable spikes in traffic and ensuring high availability. Their architecture includes over 100 servers split between web servers, databases, caching, and load balancing. They employ techniques like vertical and horizontal data partitioning, atomic updates, delayed signals, consistent caching, and feature flags to scale their large Django application.